DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myh6

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_058935.2	Gene:	Myh6 / 29556	RGDID:	62029	Length:	1939	Species:	Rattus norvegicus

Alignment Length:	1089	Identity:	329/1089 - (30%)
Similarity:	527/1089 - (48%)	Gaps:	195/1089 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:| .:..|.|.:.|||:|:...:||||.|...::|||||.||:|..:.|.|||.|...|.
  Rat    87 IEDMAML-TFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEA 150

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAAC------------SGNQT 156
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|:.            :.|:.
  Rat   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRSKKDNPNANKG 215

  Fly   157 TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221
            |:|   |:::::||.|||||||||.||||||||||::.|.|...|.....:|..||||||||:.|
  Rat   216 TLE---DQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQ 277

  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286
            :..|||:|||||:|:.....||..|.:......|::::.| ..:|..|:|::.......|..|:.
  Rat   278 LKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQG-EVSVASIDDSEELLATDSAFDVLG 341

  Fly   287 FTKEEQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTID 349
            ||.||:..::.:..:|:|.||:.|.:.  |..|:.:..:....:|.|:|:|:::|...|.|..:.
  Rat   342 FTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAEPDGTEDADKSAYLMGLNSADLLKGLCHPRVK 406

  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414
            ...:.||...:.:...|:..||||:||:::|:|:|.|:|.:|   ||:..|...:|:|||.||||
  Rat   407 VGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEI 468

  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIIS 479
            |..|||||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||:|
  Rat   469 FDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMS 533

  Fly   480 ILDEECLRPGEPTDKTFLEKL-TQKLAQHHHYVCHEKAPAHIKKIMLRDE--FRLVHYAGEVTYS 541
            ||:|||:.| :.||.||..|| ...|.:.:::    :.|.::|.   :.|  |.||||||.|.|:
  Rat   534 ILEEECMFP-KATDMTFKAKLYDNHLGKSNNF----QKPRNVKG---KQEAHFSLVHYAGTVDYN 590

  Fly   542 VNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP----------------EKELRSLKRPETAITQ 590
            :.|:|:||.|.|...:.....|:...::...|.                :|:..|.   :|....
  Rat   591 ILGWLEKNKDPLNETVVGLYQKSSLKLMATLFSTYASADTGDSGKGKGGKKKGSSF---QTVSAL 652

  Fly   591 FRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTY 655
            .|.:||.||..|....|.::|||.||:.:...|.::.||:||::..|::|.:|:.|.||..|..|
  Rat   653 HRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILY 717

  Fly   656 ELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQ 720
            ..|.:||:.|:.:..|..:.....| |.::|:..|..|..:|:.|.||:|.: ...|...|:...
  Rat   718 GDFRQRYRILNPAAIPEGQFIDSRK-GAEKLLGSLDIDHNQYKFGHTKVFFK-AGLLGLLEEMRD 780

  Fly   721 EKKHEIAAIIQAHWKGLMQR---RKYLKLRAQVIIMQSYCRRKLAQQAAKK--RREAADKIRAFI 780
            |:...|...|||..:|.:.|   :|.::.|..::::|...|   |....|.  ..:...||:..:
  Rat   781 ERLSRIITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIR---AFMGVKNWPWMKLYFKIKPLL 842

  Fly   781 KGFITRNDAPNGFNEEF--------IANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILH 837
            |...|..:..| ..|||        .:.|:|       |||..|::               .:|
  Rat   843 KSAETEKEMAN-MKEEFGRVKDALEKSEARR-------KELEEKMV---------------SLL- 883

  Fly   838 RLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASS-------VSTWFQEDRIPKEHI 895
                             |:|...:|:|.||      ::|.|.:       :....|.:...||..
  Rat   884 -----------------QEKNDLQLQVQAE------QDNLADAEERCDQLIKNKIQLEAKVKEMT 925

  Fly   896 QRVND--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSR-----------DRF 931
            :|:.|  .:.:...:::.|.:..|::.                ::|..:::           |..
  Rat   926 ERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 990

  Fly   932 ILLSNKAIYVLDGKTYKQKHRLPLD-------------KIDFTLTNHNDDL-------MVIRIPL 976
            |....|     :.|..::.|:..||             |....|....|||       ..:|:.|
  Rat   991 IAKLTK-----EKKALQEAHQQALDDLQAEEDKVNTLIKSKVKLEQQVDDLEGSLEQEKKVRMDL 1050

  Fly   977 DLKKDK--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023
            :..|.|  |||.|....|::...               |:..||..:.|
  Rat  1051 ERAKRKLEGDLKLTQESIMDLEN---------------DKLQLEEKLKK 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	260/713 (36%)
		MYSc_Myo1	52..707	CDD:276829	255/687 (37%)
		Myosin_TH1	863..1035	CDD:283635	38/219 (17%)
Myh6	NP_058935.2	Myosin_N	34..72	CDD:397036
		MYSc_class_II	99..768	CDD:276951	255/687 (37%)
		Actin-binding	657..679		10/21 (48%)
		Actin-binding	759..773		4/14 (29%)
		Calmodulin-binding. /evidence=ECO:0000250	790..807		6/16 (38%)
		Calmodulin-binding. /evidence=ECO:0000250	816..833		4/19 (21%)
		Myosin_tail_1	848..1925	CDD:396244	52/304 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1908..1939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000