Protein Alignment Myo61F and MYO1H

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 1056
• Identity: 514/1056 - (48%)
• Similarity: 709/1056 - (67%)
• Gaps: 45/1056 - (4%)

  Fly    27 METGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDH 91
            ||..|..||:.||||||||:.|.||.||:.||:|||.|:|||||||.:|:|||||::|.|||...
Human     1 MEGALTARDKVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQ 65

  Fly    92 VKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQT 156
            ::.|:..:|:|:|||::|:.|||:|.:..|.....:|||||||:||||||||:|::.|.......
Human    66 MELYQGVNFFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILEYFAVTCPMTQ 130

  Fly   157 TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221
            :::..:|:||.|||||||||||:|.||||||||||||||||||:|.|:||:|::||:||||||.|
Human   131 SLQIARDRLLFSNPVLEAFGNARTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQ 195

  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286
            ..||||||||||||||.:|..|..|.|||....|.||:.|.....:.|:|.:.:|.|..|.:|||
Human   196 NEGERNFHIFYQLLAGGEEERLSYLGLERDPQLYKYLSQGHCAKESSISDKNDWKTVSNAFSVID 260

  Fly   287 FTKEEQREIFGIVASILHLGNVGFTE-VEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDA 350
            ||:.:...:|||:||:|||||:||.| .:|.|.:.....:...|:||||:.|.|..|||||.|:|
Human   261 FTEADLENLFGIIASVLHLGNIGFEEDDQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEA 325

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            :.:.|..||..||::|||||:|||||.|.|:|||.::|.||..|:  .:|..|:|:|||||||:|
Human   326 KTEEVICPLTLELSVYARDAMAKAVYGRTFTWLVNKINSSLVNKD--FTRKTVIGLLDIYGFEVF 388

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISI 480
            .||.|||||||:||||||||.||.|||:||.||..|||||.|::||:||:||:|:||:|||||||
Human   389 DKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYEMEGIEWEPIKYFNNKIICDLVEERHKGIISI 453

  Fly   481 LDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGF 545
            |||||:|||..||.:|||||.:|:.:|.|:...:.|....:|.:...||||:||||||||...||
Human   454 LDEECIRPGPATDLSFLEKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGF 518

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMCKEPSYI 610
            |:||||||:|.|||.|.|:.|.|:|.||...||.:.:||.|..|||:.||::|::.|:.||||||
Human   519 LEKNNDLLYRHLKEVLCKSKNIILRECFLLAELENRRRPPTVGTQFKNSLSSLLETLISKEPSYI 583

  Fly   611 RCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFL---------------- 659
            |||||||.:..:.|:|.|:.||:|||||||:||||||||||||.||.||
Human   584 RCIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYLGVELSHWVERLM 648

  Fly   660 ------ERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDA 718
                  :|||||...|||::.||  |..||::|:|.:|:..|:|::|:||:|||:|||||.||||
Human   649 MSLFYKDRYKSLCPDTWPHWHGP--PAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATEDA 711

  Fly   719 YQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGF 783
            ::..||::.|.|||.:|..:.||:|:|.|...|.::::.|..||::|.::|:.|...||.|||||
Human   712 FEFSKHQLVARIQATYKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKWAVRIIRKFIKGF 776

  Fly   784 ITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIY 848
            |:||......|||||...::.::|.|...||..||||||...||..|.||.:|.::...:|.:.|
Human   777 ISRNKPLCPDNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPPGILENASDLLRKMCVRNLVQKY 841

  Fly   849 RLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKY 913
            ...:|.::|...:.||:..::|:|:|:.|..|::..|...||.:..|   |..|......|:::|
Human   842 CRGITAERKAMMQQKVVTSEIFRGRKDGYTESLNQPFVNSRIDEGDI---NPKVLQLISHEKIQY 903

  Fly   914 QSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHNDDLMVI 972
            .....|:||.|:|:|.|.::|:.||.||::....||       ||::      :.:|.:|.::||
Human   904 GVPVIKYDRKGFKARQRQLILTQKAAYVVELAKIKQ-------KIEYSALKGVSTSNLSDGILVI 961

  Fly   973 RIPLDLKKDKGDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEP 1037
            .:..:..|.|||.:|....:.|..|.::..|...:||::| :.||:..:..||.|.|...||.|.
Human   962 HVSPEDSKQKGDAVLQCGHVFEAVTKLVMLVKKENIVNVV-QGSLQFFISPGKEGTIVFDTGLEE 1025

  Fly  1038 GVVRDK-GHLVIIGTQ 1052
            .|.::| |.|.::..:
Human  1026 QVYKNKNGQLTVVSVR 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	398/710 (56%)
		MYSc_Myo1	52..707	CDD:276829	374/677 (55%)
		Myosin_TH1	863..1035	CDD:283635	53/177 (30%)
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	396/706 (56%)
		MYSc_Myo1	26..700	CDD:276829	374/677 (55%)
		Myosin_TH1	856..1019	CDD:283635	52/173 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	812	1.000	Domainoid score	I69
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1007	1.000	Inparanoid score	I290
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52678
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm40453
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	1	1.100	-	-	O	PTHR13140
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2957
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840