Protein Alignment Myo61F and Myo95E

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001027208.1
• Gene: Myo95E / 2768680
• FlyBaseID: FBgn0039157
• Length: 1288
• Species: Drosophila melanogaster
• Alignment Length: 1326
• Identity: 346/1326 - (26%)
• Similarity: 563/1326 - (42%)
• Gaps: 358/1326 - (26%)

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            |..|.|||||. ||::||.|:.:|::.|.||||||..::::|||..:..::.|:|:.|.:|..::
  Fly     6 GTWDSVLLENL-SEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGIFQ 69

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFI------------------- 148
            :||||:.:|:.|::||.:::..||||::||||:||||..|.::.|:
  Fly    70 LPPHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQ 134

  Fly   149 ------------------AACSG-------------------------------NQTTVEGV--- 161
                              ::|||                               ::|..|.:
  Fly   135 SSTSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQ 199

  Fly   162 -----KDKLL------------------------------------------------------- 166
                 ::|::
  Fly   200 SRRHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYA 264

  Fly   167 -------------------------------------------KSNPV----------------- 171
                                                       .:||.
  Fly   265 VPTVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTE 329

  Fly   172 ----------------------------------------------------------------- 171
                                                                             
  Fly   330 SQPERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRE 394

  Fly   172 --------LEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNF 228
                    |||.|||.|.:|:||||:||..||:.||||.|:|.:|.:|:|||:|:...:.|||||
  Fly   395 CVTCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNF 459

  Fly   229 HIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQR 293
            |||||||.|||..||:.|:|.|.::.|..    |..|.....|..:|...:::|.|:..:.||..
  Fly   460 HIFYQLLLGADLQLLKSLKLYRNVEKYEL----LRNTTAMEEDRMNFHYTKRSLDVLGLSCEESN 520

  Fly   294 EIFGIVASILHLGN---VGFTEVEG--NAKVNSRDLVVTAARLLGVNASELEAALT--HRTIDAR 351
            .||.::|.:|.|||   |..|.::|  ..:|::...|...|:||.:.|..|...||  :.|..|:
  Fly   521 SIFRVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQ 585

  Fly   352 GDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQ 416
            .| |...::...|...|:.|.:.:|.|||:|||.::|.||  |.|:..:|  :.:||.||||...
  Fly   586 ED-VGCEMDARQAATNRNTLCRTLYSRLFTWLVNKINESL--KSTQREKN--LALLDFYGFEALD 645

  Fly   417 KNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISIL 481
            .||||||.||:..||:.|.|:...|:|||:.|.|||:||..::||||:.||.||::...||:|::
  Fly   646 HNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDYFDNESICELIDKPSYGILSLI 710

  Fly   482 DEECLRPGEPTDKTFLEKLTQKLAQHHHY-------VCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539
            :|    |...::...|.::.|..|.|.::       :|                |::.|||..|.
  Fly   711 NE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMC----------------FQIRHYASVVN 755

  Fly   540 YSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRS--LKRPETAITQFRASLNNLMDIL 602
            ||::.||:||:|:|.:.:.....::...:|::.|||...|.  .|:|.|..:..|..|..|:.|:
  Fly   756 YSIHRFLEKNSDMLPKYISAAFYQSKLSLVQSLFPEGNPRRQVTKKPSTLSSNIRTQLQTLLAIV 820

  Fly   603 MCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSK 667
            ..:...|:.|||||:.:..:.|:..||.|||:|:.||..:.:.|.|..|...:..|..|||.|:.
  Fly   821 KHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYKLLNS 885

  Fly   668 STWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQA 732
            .|||::.| |....|:..::::|.....::.:|...:|:|.|||:::.|...:.:..|:|.:||.
  Fly   886 LTWPHFHG-GSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAVLIQT 949

  Fly   733 HWKGLMQRRKYLKLR-AQVIIMQSY-----C--------RRKLAQQAAKKRREAAD-KIRAFIKG 782
            .::....|:::.::| :|:||..::     |        ||.|.......|.|... |.:..::.
  Fly   950 MFRMYHARKRFQRMRHSQMIISSAWRTWRECRFGIPFTGRRHLWSLYRVAREEYRSLKYKRQVRW 1014

  Fly   783 FITRNDAPNGFNEEFIANAKRMW-----LLRLAKELPTKV---LDKSWPHAPGHCEEASGILHRL 839
            .|           :.|....|.|     ||.:...||...   |...||.||....:||..|..:
  Fly  1015 AI-----------DIIGRYYRQWKIRQFLLTIPLRLPPNTLSPLSTEWPVAPAFLADASRHLRSI 1068

  Fly   840 HRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVAS 904
            :......|||.......:.:...||.|..:||.:|.:|..||...|..|.:...|.|:.....|.
  Fly  1069 YHRWKCYIYRNSFDQTARNRMREKVTASIIFKDRKASYGRSVGHPFVGDYVRLRHNQQWKKICAE 1133

  Fly   905 TFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKI-DFTLTNHNDD 968
            | ..:.:.:.....|..|...|.....::||..::.:||.:|.:.|:|:|..:| ..:|:.:.||
  Fly  1134 T-NDQYVVFADIINKIARSSGKFVPILLVLSTSSLLLLDQRTLQIKYRVPASEIYRMSLSPYLDD 1197

  Fly   969 LMVIRIPL-DLKKDKGDLILIIPRIIEFSTYIIDTVGTAS-------IVSIVDRNSLEHNVVKG- 1024
            :.|..:.. :..:.|||.:.....:||..|.:...:..|:       |.:..:.|..:..|:..
  Fly  1198 IAVFHVKASEFGRKKGDFVFQTGHVIEIVTKMFLVIQNATGKPPEIHISTEFEANFGQQTVIFSF 1262

  Fly  1025 -KGGVIDIQTGAEPGVVRDKGHLVII 1049
             .||:.|:..| .|.|.|....:.||
  Fly  1263 KYGGMSDLAQG-PPKVTRKANRMEII 1287

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	247/934 (26%)
		Myosin_TH1	863..1049	CDD:461801	48/196 (24%)
Myo95E	NP_001027208.1	Motor_domain	3..>123	CDD:473979	49/117 (42%)
		Motor_domain	<403..937	CDD:473979	204/563 (36%)
		Myosin_TH1	1092..1288	CDD:461801	50/198 (25%)