DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo61F and Myo7a

DIOPT Version :9

Sequence 1:NP_476934.2 Gene:Myo61F / 38153 FlyBaseID:FBgn0010246 Length:1052 Species:Drosophila melanogaster
Sequence 2:XP_006229804.1 Gene:Myo7a / 266714 RGDID:628830 Length:2276 Species:Rattus norvegicus


Alignment Length:1120 Identity:362/1120 - (32%)
Similarity:560/1120 - (50%) Gaps:194/1120 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 LHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAY 95
            :|.....||:|.:.|.:. :|...:.||..|:::.|||||.|.:|::||||:.|.||:.:|::.|
  Rat   120 MHPTSVHGVEDMIRLGDL-NEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSSEHIRQY 183

  Fly    96 RNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG 160
            .||...||||||||:.||.:.::...||.||.:||||||:||||::|.:|||:||.||..:.:| 
  Rat   184 TNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIE- 247

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
              .::|::.|:|||||||||.|||||||||||:||.|:.:||..|..|..||||||||..|...|
  Rat   248 --QQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDE 310

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            ||:|:||.:|.|.:|...::|.|.:|.| |:||..|...|.....|:..:..::.|:.|:.||..
  Rat   311 RNYHVFYCMLEGMNEEEKKKLGLGQAAD-YNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDT 374

  Fly   291 EQREIFGIVASILHLGNVGFTEVEGNAKVNSRDL-----VVTAARLLGVNASELEAALTHRTIDA 350
            |..||..::|:|||:||:.: |......:::.::     :.|||..|.||..:|.:.||.||:..
  Rat   375 ENWEILKLLAAILHMGNLQY-EARTFENLDACEVLFSPSLATAASHLEVNPPDLMSCLTSRTLIT 438

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISL---QAKETRASRNNVMGILDIYGF 412
            ||:.|::||::|.|:..|||..|.:|.|||.|:|:::|.::   .::|...||.:: |:|||:||
  Rat   439 RGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRSI-GLLDIFGF 502

  Fly   413 EIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGI 477
            |.|..|||||.||||.||.|||.|:....|.||:||..|.|:|:.:|:.||:...::|..:...:
  Rat   503 ENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNV 567

  Fly   478 ISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYV----CHEKAPAHIKKIMLRDEFRLVHYAGEV 538
            ||::|||...| :.||.|.|.||..:...:.:||    .||            .:|.:.|:||.|
  Rat   568 ISLIDEESKFP-KGTDATMLHKLNSQHRLNANYVPPKNSHE------------TQFGINHFAGIV 619

  Fly   539 TYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPE-----KELRSLKRPETAITQFRASLNNL 598
            .|...|||:||.|.|..|:.:.:..:.|..|:..|..     .|.|  ||..|..:||:.||..|
  Rat   620 YYESQGFLEKNRDTLHGDIIQLVHSSRNKFVKQIFQADVAMGAETR--KRSPTLSSQFKRSLELL 682

  Fly   599 MDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYK 663
            |..|...:|.::||||||:.:...:|:..|.:.|::|.|:||.:|:|.||:..|.::..|:|||:
  Rat   683 MRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYR 747

  Fly   664 SLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHE--- 725
            .|.....|.|| ....:...|::.:.:....:.:::|:||:|::      |..|...|.:.:   
  Rat   748 VLLPGVKPAYK-QDDLQGTCQRMAEAVLGTHDDWQIGKTKIFLK------DHHDMLLEVERDKAI 805

  Fly   726 -------------------------IAAIIQAHWKGLMQRRKY-------LKLRA---------- 748
                                     .|.:||.||:|...|:.|       |:|:|          
  Rat   806 TDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQ 870

  Fly   749 ------QVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEF--IANAKRMW 805
                  ::|..|:.||..|.::|.:.|..|...::|:.:|.|.|. .......|:  ...|:||.
  Rat   871 YRLARQRIIKFQARCRAYLVRRAFRHRLWAVITVQAYARGMIARR-LHRRLRVEYWRRLEAERMR 934

  Fly   806 LL---RLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYR------LKLTPQQKRQFE 861
            |.   :|.||:..|...          |||    .|.|:..||::.|      ||...:.:|:.|
  Rat   935 LAEEEKLRKEMSAKKAK----------EEA----ERKHQERLAQLAREDAERELKEKEEARRKKE 985

  Fly   862 LKVLAEKVFKGKKNNYASSVSTWF-----------QEDRIPK--EHIQR-----VNDFVASTF-- 906
            |....|:. :.:..|::..|...|           ||.:.|.  |.::|     |.:.|.:..  
  Rat   986 LLQQMERA-RHEPINHSDMVDKMFGFLGTSSGLPGQEGQAPSGFEDLERGRREMVEEDVDAALPL 1049

  Fly   907 ---GSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDD 968
               ..|.|....| .||                 |.....|.|.....|.||.:   .|..|:|:
  Rat  1050 PDEDEEDLSEYKF-AKF-----------------AATYFQGTTTHSYTRRPLKQ---PLLYHDDE 1093

  Fly   969 ----------LMVIRIPLDLKK--------DKGDLILIIPRIIEF---STY-----IIDTVGTAS 1007
                      :.::|...||.:        |..:.|.::.:|.|.   .||     .:...|.|.
  Rat  1094 GDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGEAQ 1158

  Fly  1008 IVSIVDRNSLEHNVV 1022
            :.....:.|::|.:|
  Rat  1159 LSEGQKKTSVKHKLV 1173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo61FNP_476934.2 MYSc 32..720 CDD:214580 277/704 (39%)
MYSc_Myo1 52..707 CDD:276829 269/671 (40%)
Myosin_TH1 863..1035 CDD:283635 39/209 (19%)
Myo7aXP_006229804.1 MYSc 121..802 CDD:214580 278/709 (39%)
MYSc_Myo7 140..790 CDD:276832 269/671 (40%)
IQ 827..848 CDD:197470 7/20 (35%)
MAP7 <918..996 CDD:283355 23/92 (25%)
eIF3_subunit 936..>991 CDD:285763 17/68 (25%)
MyTH4 1078..1314 CDD:214535 20/99 (20%)
B41 1320..1535 CDD:214604
FERM_N 1323..>1362 CDD:286467
FERM_B-lobe 1424..1524 CDD:271216
FERM_C1_MyoVII 1529..1665 CDD:270019
SH3_MYO7A 1666..1730 CDD:212814
MyTH4 1808..1957 CDD:214535
B41 1964..2176 CDD:214604
FERM_M 2074..2176 CDD:278785
FERM_C2_MyoVII 2172..2267 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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