Protein Alignment Myo61F and Myh9

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_037326.2
• Gene: Myh9 / 25745
• RGDID: 3140
• Length: 1960
• Species: Rattus norvegicus
• Alignment Length: 1002
• Identity: 329/1002 - (32%)
• Similarity: 526/1002 - (52%)
• Gaps: 134/1002 - (13%)

  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNA 114
            :|.:.:.|||:|:...|||||.|...:.:||||.||||:::.|..|:.|..:||||||:|:||.|
  Rat    93 NEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVDMYKGKKRHEMPPHIYAITDTA 157

  Fly   115 FRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA--ACSGNQTTVEG-VKDKLLKSNPVLEAFG 176
            :||::::...|.:|.:||||:||||.:|||:|::|  |.|......:| ::.:||::||:|||||
  Rat   158 YRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAHVASSHKSKKDQGELERQLLQANPILEAFG 222

  Fly   177 NAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEA 241
            ||||.:|||||||||::.|.||..|..:|.||..|||||||.:.|...||.|||||.||:||.|.
  Rat   223 NAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEH 287

  Fly   242 LLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLG 306
            |..:|.|| ..:.|.:|::| :.|:....|.|.|::..:|:.::...::||..:..:::.:|.||
  Rat   288 LKTDLLLE-PYNKYRFLSNG-HVTIPGQQDKDMFQETMEAMRIMGIPEDEQMGLLRVISGVLQLG 350

  Fly   307 NVGFTEVEGNAKVNSRDLVVTAAR----LLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYA 367
            |:.|.:.....:.:..|  .|||:    |||:|.::....:....|....|.|.....:|.|.:|
  Rat   351 NIVFKKERNTDQASMPD--NTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFA 413

  Fly   368 RDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKL 432
            .:|||||.|:|:|.|||.|:|.:|.  :|:....:.:|||||.|||||..|||||.|||:.||||
  Rat   414 IEALAKATYERMFRWLVLRINKALD--KTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKL 476

  Fly   433 QQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEEK--HKGIISILDEECLRPGEPTDK 494
            ||||.......||:||:||||||..::: .|.:...:|||:.  ..||:::|||||..| :.|||
  Rat   477 QQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFP-KATDK 540

  Fly   495 TFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRD--EFRLVHYAGEVTYSVNGFLDKNNDLLFRDL 557
            :|:||:.|:...|         |...|...|:|  :|.::||||:|.|..:.:|.||.|.|..::
  Rat   541 SFVEKVVQEQGTH---------PKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNI 596

  Fly   558 KETLSKAGNGIVRNCFPEKE-LRSLKR----PETAI---------------TQFRASLNNLMDIL 602
            ...|.::.:..|...:.:.: :..|.:    .|||:               ..::..|..||..|
  Rat   597 ATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATL 661

  Fly   603 MCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSK 667
            ....|:::|||.||..:.|...:..|||.|::..|::|.:|:.|.||..|..::.|.:||:.|:.
  Rat   662 RNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTP 726

  Fly   668 STWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQA 732
            ::.|  ||....|.....::|.|..|...||:|::|:|.|                    |.:.|
  Rat   727 NSIP--KGFMDGKQACVLMIKALELDSNLYRIGQSKVFFR--------------------AGVLA 769

  Fly   733 HWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEF 797
            |    ::..:.||:...:|..|:.||..||::|..||::....::.     :.||.|.
  Rat   770 H----LEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKV-----LQRNCAA------- 818

  Fly   798 IANAKRMWLLRLAK----ELPTKVLDKSWPHAPGHCEE---ASGILHRLHRLHLARIYRLKLTPQ 855
                    .|||..    .|.|||  |...::..|.:|   ....|.::...|||...|  ||..
  Rat   819 --------YLRLRNWQWWRLFTKV--KPLLNSIRHEDELLAKEAELTKVREKHLAAENR--LTEM 871

  Fly   856 QKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDR----IPKEHIQRV-NDFVASTFGSEQLKYQS 915
            :..|.:|  :|||:...::....:.:....:|.|    ..|:.::.: :|..|.....|
  Rat   872 ETMQSQL--MAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEE------ 928

  Fly   916 FCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQ---KHRLPLDKI--DFTLTNHNDDLMVIRIP 975
                 :|..|...::..:..|  |..|:.:..::   :.:|.|:|:  :..|....:|.:::...
  Rat   929 -----ERCQYLQAEKKKMQQN--IQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEDQIIMEDQ 986

  Fly   976 -LDLKKDKGDLILIIPRIIEFSTYIID 1001
             ..|.|:|.   |:..|:.||:|.:::
  Rat   987 NCKLAKEKK---LLEDRVAEFTTNLME 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	264/686 (38%)
		Myosin_TH1	863..1049	CDD:461801	27/150 (18%)
Myh9	NP_037326.2	Myosin_N	27..72	CDD:460670
		Motor_domain	95..764	CDD:473979	264/686 (38%)
		Myosin_tail_1	842..1921	CDD:460256	38/189 (20%)