DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1e

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_775124.1	Gene:	Myo1e / 25484	RGDID:	3144	Length:	1107	Species:	Rattus norvegicus

Alignment Length:	966	Identity:	382/966 - (39%)
Similarity:	556/966 - (57%)	Gaps:	111/966 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYR 96
            |....:||.|.|||... :|.:.:.|||||:.:|.|:||||.|||||||:||:|.:.:..::.|:
  Rat    14 HNVKHSGVDDMVLLSKI-TESSIVENLKKRYMDDYIFTYIGSVLISVNPFKQMPYFGEKEIEMYQ 77

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGV 161
            ....||.||||:|:.|:.:|::|.:...|||:||||||:|||.|:|.::.:::..||....|:.|
  Rat    78 GAAQYENPPHIYALADSMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYVSRVSGGGPKVQHV 142

  Fly   162 KDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGER 226
            ||.:|:|||:|||||||||.||:||||||||.:|||...|.|.||.|.|:||||||||.:..|||
  Rat   143 KDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGER 207

  Fly   227 NFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGT--VTRINDADSFKQVQQALTVIDFTK 289
            :|||||||:.||.....|.|.: .::|.|.||:  |:|:  |..|:|...|::...|:.||....
  Rat   208 SFHIFYQLIEGASPEQKQSLGI-TSMDYYYYLS--LSGSYKVDDIDDKRDFQETLHAMNVIGIFS 269

  Fly   290 EEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDA---- 350
            |||..:..|||.||||||:.|.||...|.|.|.:.:...|.|||:|...|:..||.|.:|:
  Rat   270 EEQTLVLQIVAGILHLGNINFKEVGNYAAVESEEFLAFPAYLLGINQDRLKEKLTSRQMDSKWGG 334

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            :.:.:...||.|.|.|.|||||||::.|:|.:||..:|   :|.|......|: |:|||||||||
  Rat   335 KSESIHVTLNVEQACYTRDALAKALHARVFDFLVDSIN---KAMEKDHEEYNI-GVLDIYGFEIF 395

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEK--HKGII 478
            |||.||||||||.||||||:|||||||:||:||.:|||.|.|:|||:||::|:|||.|  ..||:
  Rat   396 QKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIESKVNPPGIM 460

  Fly   479 SILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTY 540
            ||||:.|.   ..||..|:|.|:||..::..|.|:....:.            |.:.||||:|:|
  Rat   461 SILDDVCATMHAVGEGADQTLLQKLQMQIGSHEHFNSWNQG------------FIIHHYAGKVSY 513

  Fly   541 SVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLK-RPETAITQFRASLNNLMDILMC 604
            .::||.::|.|:||.||.|.:..:....:::.|||......| ||.||.::.:...|:|:..||.
  Rat   514 DMDGFCERNRDVLFMDLIELMQSSELPFIKSLFPENLQADKKGRPTTAGSKIKKQANDLVSTLMK 578

  Fly   605 KEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKST 669
            ..|.||||||||:.:....:.:..|.|||:||||.||:||||||:||||.::.||:||..|:|:|
  Rat   579 CTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFQKFLQRYAILTKAT 643

  Fly   670 WPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHW 734
            ||.::  |..|.||..|::.:..|.:::::|.:|:||:.|.:||..|:..:.|....|.:||..|
  Rat   644 WPVWR--GDEKQGVLHLLQSVNMDSDQFQLGRSKVFIKAPESLFLLEEMRERKYDGYARVIQKTW 706

  Fly   735 KGLMQRRKYLKLR--AQVIIMQSYCRRK-------------------LAQQAAKKRR-EAADKIR 777
            :..:.|:||:::|  |..:::....||:                   |.|...|:.: :.||.:.
  Rat   707 RKFVARKKYVQMREDASDLLLNKKERRRNSINRNFIGDYIGMEEHPELQQFVGKREKIDFADIVT 771

  Fly   778 AFIKGFITRNDAPNGFNEEFIANAKRMWLL--RLAKELPTKVLDKSWPHAPGHCEEASGILHRLH 840
            .:.:.|       .|...:.:...|.::|:  ...|:.|.|.|.|.             :|.|
  Rat   772 KYDRRF-------KGVKRDLLLTPKCLYLIGREKVKQGPDKGLVKE-------------VLKR-- 814

  Fly   841 RLHLARIYRLKLTPQQKRQF-----ELKVLAEKVFKGKKNNYASSVSTWFQE---DRIPKE---- 893
            ::.:.||..:.|:..|...|     |...|.|.||   |..:.|.::..::|   .::|.:
  Rat   815 KIEVERILSVSLSTMQDDIFILHEQEYDSLLESVF---KTEFLSLLTKRYEEKTQKQLPLKFSNT 876

  Fly   894 ---HIQRVNDFVASTFGSEQLK-YQSFCTKFDRHGYKSRDRFILL-SNKAIYVLDG 944
               .:::.|....|..||.|:: ||.|           .|..||. |||.:.|..|
  Rat   877 LELKLKKENWGPWSAGGSRQVQFYQGF-----------GDLAILKPSNKVLQVSIG 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	324/699 (46%)
		MYSc_Myo1	52..707	CDD:276829	311/666 (47%)
		Myosin_TH1	863..1035	CDD:283635	24/94 (26%)
Myo1e	NP_775124.1	MYSc	14..692	CDD:214580	324/699 (46%)
		MYSc_Myo1	33..679	CDD:276829	311/666 (47%)
		Actin-binding. /evidence=ECO:0000255	581..591		8/9 (89%)
		Myosin_TH1	719..899	CDD:283635	39/204 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	920..1052		1/2 (50%)
		SH3_MyoIe_If_like	1055..1106	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820