Protein Alignment Myo61F and myo1

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_595402.1
• Gene: myo1 / 2539659
• PomBaseID: SPBC146.13C
• Length: 1217
• Species: Schizosaccharomyces pombe
• Alignment Length: 1066
• Identity: 361/1066 - (33%)
• Similarity: 539/1066 - (50%)
• Gaps: 208/1066 - (19%)

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||.|..||.....|| ...||:.||:...||||||.|||||||::.|.|||.|.:|:|:.|:..|
pombe    41 GVDDLTLLSKITDEE-INKNLELRFRNGEIYTYIGHVLISVNPFRDLGIYTMDILKSYQGKNRLE 104

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGN-QTTVEGVKDKLL 166
            ..||::|:.:||:..:...:..||::||||||:|||||:|:::|:|...|.: .|.:|.|.:.:|
pombe   105 TSPHVYAIAENAYYQMKSYHENQCIIISGESGAGKTEAAKRIMQYITHVSKSVGTEIERVSEIIL 169

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            .:||:||:||.|||.||:||||.|||:::.|:..|.|:|..|.||||||:|:|.|:..|||||||
pombe   170 ATNPLLESFGCAKTLRNNNSSRHGKYLEMIFNSGGVPVGAKITNYLLEKNRIVNQVRNERNFHIF 234

  Fly   232 YQLLAGADEALLQELRLERALDTYSYLTDGLNG-------------TVTRINDADSFKQVQQALT 283
            ||....|.    |:.|     |||     |:.|             :|..|:|...|:....|:.
pombe   235 YQFTKSAP----QKYR-----DTY-----GIQGPENYVYTSACQCLSVDGISDEKDFQGTMNAMK 285

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGFTE-VEGNAKVNSRDLVVTAARLLGVNASELEAALTHRT 347
            ||..|:.||.|||.:::.||.|||:.|.| .:|.:.::.:.:......|:||..:.:|.|||.|.
pombe   286 VIGITEPEQDEIFRMLSIILWLGNIQFQEGQDGGSVISDKSITEFLGYLIGVPVAAIERALTIRI 350

  Fly   348 IDA-----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGIL 407
            :..     ||.|...|||...|:..||||:.|:|:.||.|:|:|:|.:|...:...|  |.:|||
pombe   351 MQTQHGARRGSVYEVPLNPTQALAVRDALSMAIYNCLFDWIVERVNKALVTSDNSVS--NSIGIL 413

  Fly   408 DIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEE 472
            ||||||||:.|||||.|||:.||||||:|||||||:||:||.||.|.|.|::||:|||:|:|||.
pombe   414 DIYGFEIFENNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIAWTPIKYFNNKVVCDLIES 478

  Fly   473 KH-KGIISILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVH 533
            |. .|:.:.:::...   ......|..|.::| ..|:.:.|:.            ..:::|.:.|
pombe   479 KRPPGLFAAMNDAIATAHADSAAADSAFAQRL-NFLSSNPHFE------------QRQNQFIVKH 530

  Fly   534 YAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP-EKELRSLKRPETAITQFRASLNN 597
            |||:||||:.|..|||.|.|..|:...:..:.|..:::.|| .:|..|.:||.||..:.:.|.|:
pombe   531 YAGDVTYSITGMTDKNKDQLATDILNLIHSSNNEFMKSIFPVAEESNSRRRPPTAGDRIKTSAND 595

  Fly   598 LMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY 662
            |::.||..:|||||.||||..::.|.::.::||||:|||||.||:|:||||||||:.::.|.:|:
pombe   596 LVETLMKCQPSYIRTIKPNQTKSPNDYDQQMVLHQIKYLGLQENIRIRRAGFAYRQAFDTFAQRF 660

  Fly   663 KSLSKSTWPNYKG----PGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKK 723
            ..||..|  :|.|    .|..|:..:|::||......:|::|.:|:||:.|.|||..||...:..
pombe   661 AVLSGKT--SYAGEYTWQGDDKSACEQILKDTNIPSSEYQMGTSKVFIKNPETLFALEDMRDKFW 723

  Fly   724 HEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRND 788
            ..:|..||..|:..::||.    .|...|.:.:.|.|:..:..:.|.|.
pombe   724 DTMATRIQRAWRSYVRRRS----EAAACIQKLWNRNKVNMELERVRNEG---------------- 768

  Fly   789 APNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLT 853
                                      ||:|...
pombe   769 --------------------------TKLLQGK-------------------------------- 775

  Fly   854 PQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQ-------L 911
             :|:|::  .:|..:.|.|   :|.|:               .:.|..:.:|.|..|       :
pombe   776 -KQRRRY--SILGSRKFYG---DYLSA---------------SKPNGTLWNTCGLSQNDHVIFSM 819

  Fly   912 KYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQK------HRLPLDKIDFT-LTNHNDDL 969
            :.:....|..|.. |...|.::|:.|.:|::..|...||      .:..:..||.. |||..||.
pombe   820 RCEVLVHKLGRTS-KPSPRQLVLTKKNLYLVITKIVDQKLTQQVEKKFAVSSIDSVGLTNLQDDW 883

  Fly   970 MVIRIPLDLKKDKGDLILIIPRIIEFSTYI-----------------------IDTVGTASIVSI 1011
            :.||   :.....||:.|......||.|.:                       :.||.||.
pombe   884 VAIR---NKSSQNGDMFLRCFFKTEFITTLKRINRNIQVIVGPTIQYCRKPGKVQTVKTAK---- 941

  Fly  1012 VDRNSLEHNVVKGKGGVIDIQTGAEP 1037
             |..:.:::..  |.|.|.:.||..|
pombe   942 -DETTKDYDYY--KSGTIHVGTGLPP 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	286/683 (42%)
		Myosin_TH1	863..1049	CDD:461801	45/212 (21%)
myo1	NP_595402.1	COG5022	1..1217	CDD:227355	361/1066 (34%)