DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and myo1

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_595402.1	Gene:	myo1 / 2539659	PomBaseID:	SPBC146.13c	Length:	1217	Species:	Schizosaccharomyces pombe

Alignment Length:	1066	Identity:	361/1066 - (33%)
Similarity:	539/1066 - (50%)	Gaps:	208/1066 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||.|..||.....|| ...||:.||:...||||||.|||||||::.|.|||.|.:|:|:.|:..|
pombe    41 GVDDLTLLSKITDEE-INKNLELRFRNGEIYTYIGHVLISVNPFRDLGIYTMDILKSYQGKNRLE 104

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGN-QTTVEGVKDKLL 166
            ..||::|:.:||:..:...:..||::||||||:|||||:|:::|:|...|.: .|.:|.|.:.:|
pombe   105 TSPHVYAIAENAYYQMKSYHENQCIIISGESGAGKTEAAKRIMQYITHVSKSVGTEIERVSEIIL 169

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            .:||:||:||.|||.||:||||.|||:::.|:..|.|:|..|.||||||:|:|.|:..|||||||
pombe   170 ATNPLLESFGCAKTLRNNNSSRHGKYLEMIFNSGGVPVGAKITNYLLEKNRIVNQVRNERNFHIF 234

  Fly   232 YQLLAGADEALLQELRLERALDTYSYLTDGLNG-------------TVTRINDADSFKQVQQALT 283
            ||....|.    |:.|     |||     |:.|             :|..|:|...|:....|:.
pombe   235 YQFTKSAP----QKYR-----DTY-----GIQGPENYVYTSACQCLSVDGISDEKDFQGTMNAMK 285

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGFTE-VEGNAKVNSRDLVVTAARLLGVNASELEAALTHRT 347
            ||..|:.||.|||.:::.||.|||:.|.| .:|.:.::.:.:......|:||..:.:|.|||.|.
pombe   286 VIGITEPEQDEIFRMLSIILWLGNIQFQEGQDGGSVISDKSITEFLGYLIGVPVAAIERALTIRI 350

  Fly   348 IDA-----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGIL 407
            :..     ||.|...|||...|:..||||:.|:|:.||.|:|:|:|.:|...:...|  |.:|||
pombe   351 MQTQHGARRGSVYEVPLNPTQALAVRDALSMAIYNCLFDWIVERVNKALVTSDNSVS--NSIGIL 413

  Fly   408 DIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEE 472
            ||||||||:.|||||.|||:.||||||:|||||||:||:||.||.|.|.|::||:|||:|:|||.
pombe   414 DIYGFEIFENNSFEQLCINYVNEKLQQIFIELTLKTEQEEYVREQIAWTPIKYFNNKVVCDLIES 478

  Fly   473 KH-KGIISILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVH 533
            |. .|:.:.:::...   ......|..|.::| ..|:.:.|:.            ..:::|.:.|
pombe   479 KRPPGLFAAMNDAIATAHADSAAADSAFAQRL-NFLSSNPHFE------------QRQNQFIVKH 530

  Fly   534 YAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFP-EKELRSLKRPETAITQFRASLNN 597
            |||:||||:.|..|||.|.|..|:...:..:.|..:::.|| .:|..|.:||.||..:.:.|.|:
pombe   531 YAGDVTYSITGMTDKNKDQLATDILNLIHSSNNEFMKSIFPVAEESNSRRRPPTAGDRIKTSAND 595

  Fly   598 LMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY 662
            |::.||..:|||||.||||..::.|.::.::||||:|||||.||:|:||||||||:.::.|.:|:
pombe   596 LVETLMKCQPSYIRTIKPNQTKSPNDYDQQMVLHQIKYLGLQENIRIRRAGFAYRQAFDTFAQRF 660

  Fly   663 KSLSKSTWPNYKG----PGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKK 723
            ..||..|  :|.|    .|..|:..:|::||......:|::|.:|:||:.|.|||..||...:..
pombe   661 AVLSGKT--SYAGEYTWQGDDKSACEQILKDTNIPSSEYQMGTSKVFIKNPETLFALEDMRDKFW 723

  Fly   724 HEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRND 788
            ..:|..||..|:..::||.    .|...|.:.:.|.|:..:..:.|.|.
pombe   724 DTMATRIQRAWRSYVRRRS----EAAACIQKLWNRNKVNMELERVRNEG---------------- 768

  Fly   789 APNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLT 853
                                      ||:|...
pombe   769 --------------------------TKLLQGK-------------------------------- 775

  Fly   854 PQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQ-------L 911
             :|:|::  .:|..:.|.|   :|.|:               .:.|..:.:|.|..|       :
pombe   776 -KQRRRY--SILGSRKFYG---DYLSA---------------SKPNGTLWNTCGLSQNDHVIFSM 819

  Fly   912 KYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQK------HRLPLDKIDFT-LTNHNDDL 969
            :.:....|..|.. |...|.::|:.|.:|::..|...||      .:..:..||.. |||..||.
pombe   820 RCEVLVHKLGRTS-KPSPRQLVLTKKNLYLVITKIVDQKLTQQVEKKFAVSSIDSVGLTNLQDDW 883

  Fly   970 MVIRIPLDLKKDKGDLILIIPRIIEFSTYI-----------------------IDTVGTASIVSI 1011
            :.||   :.....||:.|......||.|.:                       :.||.||.
pombe   884 VAIR---NKSSQNGDMFLRCFFKTEFITTLKRINRNIQVIVGPTIQYCRKPGKVQTVKTAK---- 941

  Fly  1012 VDRNSLEHNVVKGKGGVIDIQTGAEP 1037
             |..:.:::..  |.|.|.:.||..|
pombe   942 -DETTKDYDYY--KSGTIHVGTGLPP 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	299/710 (42%)
		MYSc_Myo1	52..707	CDD:276829	286/683 (42%)
		Myosin_TH1	863..1035	CDD:283635	43/208 (21%)
myo1	NP_595402.1	MYSc	38..720	CDD:214580	299/710 (42%)
		MYSc_Myo1	54..707	CDD:276829	287/684 (42%)
		Myosin_TH1	765..944	CDD:283635	46/282 (16%)
		SH3_Myosin-I_fungi	1111..1162	CDD:212792
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	519	1.000	Domainoid score	I47
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	555	1.000	Inparanoid score	I192
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm47025
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.820