Protein Alignment Myo61F and Myo5a

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_038936774.1
• Gene: Myo5a / 25017
• RGDID: 3143
• Length: 1880
• Species: Rattus norvegicus
• Alignment Length: 1178
• Identity: 353/1178 - (29%)
• Similarity: 547/1178 - (46%)
• Gaps: 232/1178 - (19%)

  Fly     6 KSLIFAIMDTKDYIDFNSQLKMETGLHERD---RAGVQDFVLLENYQSEEAFIGNLKKRF-QEDL 66
            |.|:..:.:.|| :::....|.....|.|:   ..|..|...| :|..|.|.:.||:.|| ...|
  Rat    36 KVLLLHLEEGKD-LEYRLDPKTSELPHLRNPDILVGENDLTAL-SYLHEPAVLHNLRVRFIDSKL 98

  Fly    67 IYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISG 131
            ||||.|.||:::|||:|||||.:|.:.||..::..:|.||||||.:.|::.:..:.|.|.:::||
  Rat    99 IYTYCGIVLVAINPYEQLPIYGEDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSG 163

  Fly   132 ESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQ 196
            |||:|||.::|..:::.|..||:.:.. .|::|:|.|||::|:.|||||.|||||||||||::|.
  Rat   164 ESGAGKTVSAKYAMRYFATVSGSASEA-NVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIG 227

  Fly   197 FDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDG 261
            ||.:...||.|:..|||||||||.|...|||:||||||.|.|.....:.|||..| |::.|...|
  Rat   228 FDKRYRIIGANMRTYLLEKSRVVFQAEEERNYHIFYQLCASAKLPEFKMLRLGNA-DSFHYTKQG 291

  Fly   262 LNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKV--NSRDL 324
            .:..:..::||......:||.|::..::..|..||.|:|.|||||||||...:.::..  ...:.
  Rat   292 GSPMIEGVDDAKEMAHTRQACTLLGISESYQMGIFRILAGILHLGNVGFASRDSDSCTIPPKHEP 356

  Fly   325 VVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNI 389
            ::....|:||:..|:...|.||.:....:....|:::..|..|||||||.:|.:||:|:|..:|
  Rat   357 LIIFCDLMGVDYEEMCHWLCHRKLATATETYIKPISKLQATNARDALAKHIYAKLFNWIVGHVN- 420

  Fly   390 SLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIE 454
              ||..:...:::.:|:|||||||.|:.|||||||||:.||||||.|.....|.||:||.:|.|.
  Rat   421 --QALHSAVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIP 483

  Fly   455 WIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCH-EKAPA 518
            |..::::||:...||||.| .||:.:|||||..| :.||.|:.:||         |..| .|...
  Rat   484 WTLIDFYDNQPCINLIESK-LGILDLLDEECKMP-KGTDDTWAQKL---------YNTHLNKCAL 537

  Fly   519 HIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKE------ 577
            ..|..|....|.:.|:|.:|.|...|||:||.|.:|.:..:.|..:...::...|.:.|
  Rat   538 FEKPRMSNKAFIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKSSKFKMLPELFQDDEKAISPT 602

  Fly   578 --------------LRSLK-RP--------ETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQ 619
                          ::..| ||        :|...|||.||:.||:.|....|.|:|||||||.:
  Rat   603 SATSSGRTPLTRVPVKPTKGRPGQTAKEHKKTVGLQFRNSLHLLMETLNATTPHYVRCIKPNDFK 667

  Fly   620 TANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQ 684
            ....|:::..:.|::..|::|.:|:..|||..|.||:.|..||:.|.|..    ...|..|...|
  Rat   668 FPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQK----DVLGDRKQTCQ 728

  Fly   685 QLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEK--------------------------- 722
            .:::.|..|::||:.|:||:|.|..:.      ||.||
  Rat   729 NVLEKLILDKDKYQFGKTKIFFRAGQV------AYLEKLRADKLRAACIRIQKTIRGWLLRKRYL 787

  Fly   723 --------------------------KHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKL 761
                                      :.:.|..||.:|:..:.||||...||..|::|||.|..|
  Rat   788 CMQRAAITVQRYVRGYQARCYAKFLRRTKAATTIQKYWRMYVVRRKYKIRRAATIVLQSYLRGYL 852

  Fly   762 AQQAAKK--RREAADKIRAFIKGFITRNDAPNGFNEEFIANA--KRMWLLRLAKELPT------- 815
            |:...:|  |...|..|:..::|::.|...............  :||...|..|:|..
  Rat   853 ARNRYRKILREHKAVIIQKRVRGWLARTHYKRTMKAIIYLQCCFRRMMAKRELKKLKIEARSVER 917

  Fly   816 --------------------------KVLDKSWPHAPG-HCEEASGILHRLHRLHLA-------- 845
                                      |.|.:...:..| :..|...:.:.:.||.|:
  Rat   918 YKKLHIGMENKIMQLQRKVDEQNKDYKCLMEKLTNLEGVYNSETEKLRNDVERLQLSEEEAKVAT 982

  Fly   846 --------RIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFV 902
                    .|.:|:...:|.|. |.|.:.|:..|.|:.. ...||...:|:.:.|:..:.:|..:
  Rat   983 GRVLSLQEEIAKLRKDLEQTRS-EKKSIEERADKYKQET-EQLVSNLKEENTLLKQEKETLNHLM 1045

  Fly   903 AS----------------------TFGSEQLKYQSFCTKFDR--------------------HGY 925
            ..                      ....|:|:||:...:|.|                    .|:
  Rat  1046 VEQAKEMTETMERKLVEETKQLELDLNDERLRYQNLLNEFSRLEERYDDLKEEMTLMLNVPKPGH 1110

  Fly   926 KSRDRFILLSNKAIYVLDGKTYK-----------QKHRLPLD-----KIDFTLTNHNDDLMVIRI 974
            |..|. ...||::.|....:..:           .:.::|||     |:...:|....:..:::.
  Rat  1111 KRTDS-THSSNESEYTFSSEFAETEDIAPRTEEPTEKKVPLDMSLFLKLQKRVTELEQEKQLMQD 1174

  Fly   975 PLDLKKDK 982
            .||.|:::
  Rat  1175 ELDRKEEQ 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	276/723 (38%)
		MYSc_Myo1	52..707	CDD:276829	267/687 (39%)
		Myosin_TH1	863..1035	CDD:283635	29/178 (16%)
Myo5a	XP_038936774.1	COG5022	7..1275	CDD:227355	353/1178 (30%)
		MYSc_Myo5	83..751	CDD:276831	267/687 (39%)
		Smc	1157..>1484	CDD:224117	5/26 (19%)
		Myo5a_CBD	1506..1880	CDD:271262

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910