DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo61F and Myo1h

DIOPT Version :9

Sequence 1:NP_476934.2 Gene:Myo61F / 38153 FlyBaseID:FBgn0010246 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001158045.1 Gene:Myo1h / 231646 MGIID:1914674 Length:1022 Species:Mus musculus


Alignment Length:1032 Identity:508/1032 - (49%)
Similarity:702/1032 - (68%) Gaps:25/1032 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 METGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDH 91
            ||..|..||:.||||||||:.|.||.||:.||:|||:|:|||||||.:|:|||||::|.|||...
Mouse     1 MEGALTARDKVGVQDFVLLDAYTSESAFLENLRKRFRENLIYTYIGTLLVSVNPYQELGIYTASQ 65

  Fly    92 VKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQT 156
            ::.|:..:|:|:|||::|:.|||:|.:..|.....:|||||||:||||||||:||:.|.......
Mouse    66 MELYQGVNFFELPPHVYAIADNAYRMMCSELNNHFILISGESGAGKTEASKKILQYFAVTCPMTE 130

  Fly   157 TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221
            :::..:|:||.|.|||||||||||.||||||||||||||||||:|.|:||:|::||:||||||.|
Mouse   131 SLQIARDRLLLSIPVLEAFGNAKTLRNDNSSRFGKYMDIQFDFQGVPVGGHIISYLIEKSRVVYQ 195

  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286
            ..||||||||||||||.....|..|.|||....|.||:.|.....:.|:|.:.::.|..|.:||.
Mouse   196 NHGERNFHIFYQLLAGGGSERLASLGLERDPQLYKYLSQGHCARESPISDKNDWETVCGAFSVIG 260

  Fly   287 FTKEEQREIFGIVASILHLGNVGFT-EVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDA 350
            ||:.:...:|||:||:||||||.|. :.:|.|.|.....:...|:||||..:.|..|||||.|:|
Mouse   261 FTEADLENLFGIIASVLHLGNVCFKGDKQGCASVPDTHEIKWIAKLLGVCPAVLLEALTHRKIEA 325

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            :.:.|..||..||::|||||:|||||.|.|:|||.|:|.||..|:  .::..|:|:|||||||:|
Mouse   326 KTEEVICPLTVELSVYARDAMAKAVYGRTFTWLVNRINSSLVNKD--FTQKTVIGLLDIYGFEVF 388

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISI 480
            .||.|||||||:||||||||.||.|||:||.||..|||||..|:||:||:||:|:||:|:|||||
Mouse   389 DKNGFEQFCINYCNEKLQQLLIERTLKAEQAEYESEGIEWETVQYFNNKIICDLVEERHRGIISI 453

  Fly   481 LDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGF 545
            |||||:|||..||.:|||||.:|:.:|.|:...:.|....:|.:...||.|:||||||||...||
Mouse   454 LDEECIRPGPATDLSFLEKLEEKVGKHAHFQTRKLAGPKGRKRIGWLEFCLLHYAGEVTYCTKGF 518

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMCKEPSYI 610
            |:||||||:|.|||.|..:.|.|:|.||...||.:.:||.|..|||:.||::|::||:.||||||
Mouse   519 LEKNNDLLYRHLKEVLCSSKNSILRECFLVAELENRRRPPTVGTQFKNSLSSLLEILISKEPSYI 583

  Fly   611 RCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKG 675
            ||||||:.:..:.|:|.|:.||:|||||||:||||||||||||.||.||:|||||...|||::.|
Mouse   584 RCIKPNERKEPSKFDDFLISHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYKSLCPDTWPHWHG 648

  Fly   676 PGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQR 740
            |  |..||::|:|.:|:..:.|::|:||:|||:|||||.||||::..||::.:.|||.:||.:.|
Mouse   649 P--PGEGVERLIKYIGYQPQDYKLGKTKIFIRFPRTLFATEDAFEFSKHQLVSRIQATYKGCLGR 711

  Fly   741 RKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMW 805
            |:|:|.|.....::::.|..||::..|:||.|...||.|:||||.|:......||||:...::.:
Mouse   712 REYMKKRQAATKLEAHWRGVLARKEIKRRRWAVQIIRRFVKGFINRDKPLCPDNEEFVVLVRKNY 776

  Fly   806 LLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVF 870
            :|.|...:|..||||||...||..|.||.:|.|:...:|.|.|...::.::|...:.||:..::|
Mouse   777 ILNLRYHVPKNVLDKSWLRPPGILENASNLLRRMCTRNLVRKYCRGISAERKAMMQQKVVTSEIF 841

  Fly   871 KGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLS 935
            :|||..||.|::..|...|:.:.:|   |..|....|||:::|.....|:||.|:|:|.|.:||:
Mouse   842 RGKKEGYAESLNQLFAGSRLDESNI---NPKVLQLLGSEKIQYGVPVIKYDRKGFKARQRQLLLT 903

  Fly   936 NKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHNDDLMVIRI-PLDLKKDKGDLILIIPRII 993
            .::.|:::....||       ||::      :.::.:|.::||.| |.| |:.|||:||....|.
Mouse   904 QRSAYLVELSKVKQ-------KIEYAAVRGVSTSSLSDGILVIHISPAD-KQQKGDVILQCEHIF 960

  Fly   994 EFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEPGVVRDK-GHLVII 1049
            |.:|.:...:.....|.:| :.||:..|..|:.|.|..:||.|..|.:|| |.|.::
Mouse   961 EVATKLAMLIRKEHTVRVV-QGSLQFYVSPGREGTIVFETGEEDQVYKDKNGQLRVV 1016

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo61FNP_476934.2 MYSc 32..720 CDD:214580 391/688 (57%)
MYSc_Myo1 52..707 CDD:276829 367/655 (56%)
Myosin_TH1 863..1035 CDD:283635 56/178 (31%)
Myo1hNP_001158045.1 MYSc 8..689 CDD:214580 389/684 (57%)
MYSc_Myo1 26..678 CDD:276829 367/655 (56%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 568..590 15/21 (71%)
Myosin_TH1 834..1001 CDD:283635 56/178 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 810 1.000 Domainoid score I69
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1007 1.000 Inparanoid score I288
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52678
OrthoDB 1 1.010 - - D105718at33208
OrthoFinder 1 1.000 - - FOG0000187
OrthoInspector 1 1.000 - - otm42530
orthoMCL 1 0.900 - - OOG6_100187
Panther 1 1.100 - - O PTHR13140
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2957
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1110.980

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