Protein Alignment Myo61F and Myo5c

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_006510998.1
• Gene: Myo5c / 208943
• MGIID: 2442485
• Length: 1749
• Species: Mus musculus
• Alignment Length: 1071
• Identity: 345/1071 - (32%)
• Similarity: 531/1071 - (49%)
• Gaps: 170/1071 - (15%)

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQED-LIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFY 101
            |..|...| :|..|.|.:.||:.||.|. |||||.|.:|:::|||||||||.|..:.||..::..
Mouse    68 GENDLTAL-SYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMG 131

  Fly   102 EMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLL 166
            :|.||||||.:.|::.:...||.|.:::|||||:|||.:::..:::.|..|.:.:... |:||:|
Mouse   132 DMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSSSNAH-VEDKVL 195

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            .|||:.||.|||||.|||||||||||.:|.||.:...||.|:..|||||||||.|...|||:|||
Mouse   196 ASNPITEAVGNAKTTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIF 260

  Fly   232 YQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIF 296
            |||.|.|.::..:.|:|..| :.::|...|.|..:..:||.....:.|:..|::.|.|:.|.::|
Mouse   261 YQLCASAQQSEFKHLKLGSA-EEFNYTRMGGNTVIEGVNDRADMVETQKTFTLLGFKKDFQMDVF 324

  Fly   297 GIVASILHLGNVGFTEVEGN--AKVNSRDL-VVTAARLLGVNASELEAALTHRTIDARGDVVTSP 358
            .|:|:|||||||..|.| ||  :.|:..|. :.....|||:..|::...|.:|.|....:.|..|
Mouse   325 KILAAILHLGNVQVTTV-GNERSSVSEDDSHLKVFCELLGLETSKVAQWLCNRKIVTSSETVVKP 388

  Fly   359 LNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQF 423
            :.:..||.|||||||.:|..||.::|:::|   ||......::..:|:|||||||.|..||||||
Mouse   389 MTRPQAINARDALAKKIYAHLFDFIVEQIN---QALHFSGKQHTFIGVLDIYGFETFDVNSFEQF 450

  Fly   424 CINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRP 488
            |||:.||||||.|.....|.||:||.:|.|.|..::::||:.:.:|||.| .||:.:||||||.|
Mouse   451 CINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAK-MGILELLDEECLLP 514

  Fly   489 GEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLL 553
             ..||:.:|:||      ::::|  .|.....|..|....|.:.|:|.:|.|...|||:||.|.:
Mouse   515 -HGTDENWLQKL------YNNFV--NKNSLFEKPRMSNSSFIIQHFADKVEYQCEGFLEKNRDTV 570

  Fly   554 FRDLKETLSKAGNGIVRNCFPE--------------KELRSLKRPE------TAITQFRASLNNL 598
            :..|.|.|..:...:....|.|              |..:.:.:|.      |...:||:||..|
Mouse   571 YDMLVEILRASKFHLCAAFFQESPVPSSPFGAMITVKSAKQVIKPNTKHFRTTVGNKFRSSLYLL 635

  Fly   599 MDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERY- 662
            |:.|....|.|:|||||||.:....|:.:.::.|::..|::|.:|:....:..|.||..|..||
Mouse   636 METLNATTPHYVRCIKPNDEKMPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRYG 700

  Fly   663 -----KSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEK 722
                 :.||.|         ..|...:.::..|..|..:|:.|.||:|.|..:..: .|....:|
Mouse   701 ILMTQQELSLS---------DKKEVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAY-LEKLRLDK 755

  Fly   723 KHEIAAIIQAHWKGLMQRRKYLK-----------LRAQ-----------------VIIMQSYCRR 759
            ..:...:||.|.:|.:||||:|:           .|.|                 .||:|.|||.
Mouse   756 LRQDCIMIQKHVRGWLQRRKFLRERQAALTIQRYFRGQQTVRKAITATALKEAWAAIILQKYCRG 820

  Fly   760 KLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEE---FIANAKRMWLLR------------- 808
            .|.:...:..|.|...|:|..:||:.|........|.   .:....|.||.|
Mouse   821 YLVRNLYQLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRRFVLNI 885

  Fly   809 ----LAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKV 869
                ..:.|..|:.|::        .|..|::.:|..|...|:..|:...:.:.:.|........
Mouse   886 QLTYRVQRLQKKLEDQN--------RENHGLVEKLTSLAALRVGDLEKVQKLEAELEKAATHRHS 942

  Fly   870 FKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILL 934
            ::.|...|..:|     |:|:.|  :|:.|         .:|:.|             |:|
Mouse   943 YEEKGRRYRDTV-----EERLSK--LQKHN---------AELELQ-------------RER---- 974

  Fly   935 SNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDDLMVIRIPLDLKKDKGDLILIIPRIIEFSTYI 999
               |..:|..|:.:.|.:  :||:...|.:            |::|::... |::.:..|..|..
Mouse   975 ---AEQMLQEKSEELKEK--MDKLTRQLFD------------DVQKEEQQR-LVLEKGFELKTQA 1021

  Fly  1000 ----IDTVGTASIVSIVD-RNSLEHNVVKGK 1025
                |::: ...|.::.| |:.|.|.:.:|:
Mouse  1022 YEKQIESL-REEIKALKDERSQLHHQLEEGQ 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	266/684 (39%)
		Myosin_TH1	863..1049	CDD:461801	31/168 (18%)
Myo5c	XP_006510998.1	MYSc_Myo5	81..741	CDD:276831	266/684 (39%)
		IQ	831..851	CDD:459869	7/19 (37%)
		SMC_prok_B	<850..>1385	CDD:274008	46/262 (18%)
		Myo5c_CBD	1376..1743	CDD:271260