Protein Alignment Myo61F and myo-2

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 1063
• Identity: 318/1063 - (29%)
• Similarity: 511/1063 - (48%)
• Gaps: 188/1063 - (17%)

  Fly    48 YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTD 112
            :.::.:.:.|||.|:...|||||.|...:.:||||:||||||...:.:..|...|||||:|||:|
 Worm    91 FLNDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEMPPHLFAVSD 155

  Fly   113 NAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVK--------------- 162
            .|:|::::.:..|.:||:||||:||||.:|||:.:.||....|....|.|
 Worm   156 EAYRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAAQQETFGAKKAATEEDKNKKKVTL 220

  Fly   163 -DKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGER 226
             |:::::||||||||||||.||:|||||||::.|.|..:|.....:|.:||||||||:.|..|||
 Worm   221 EDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGER 285

  Fly   227 NFHIFYQLLAGADEALLQELRLERALDTYSYLTDG---LNGTVTRINDADSFKQVQQALTVIDFT 288
            .:|||||:.:.....|.::|.|.:.:..|.::...   ::|    |||.:..:...:|..::.||
 Worm   286 CYHIFYQVFSDYLPNLKKDLLLNKPVKDYWFIAQAELIIDG----INDKEEHQLTDEAFDILKFT 346

  Fly   289 KEEQREIFGIVASILHLGNVGFTE--VEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDAR 351
            ..|:.|.:.:||:::|:||:.|.:  .|..|:.:..|....||:..|:::.|...|||...:...
 Worm   347 PTEKMECYRLVAAMMHMGNMKFKQRPREEQAEPDGTDDAERAAKCFGIDSEEFLKALTRPRVKVG 411

  Fly   352 GDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQ 416
            .:.|....|.|...:|..|:||.:|.|:|:|||::.|.:|..|  ..||::.:|:|||.|||||.
 Worm   412 NEWVNKGQNIEQVNWAVGAMAKGLYSRIFNWLVKKCNQTLDQK--GISRDHFIGVLDIAGFEIFD 474

  Fly   417 KNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISIL 481
            .|||||..|||.||||||.|.......||:||.||||:|..:::..:...|..:.||..|||::|
 Worm   475 FNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIEKPLGIIAML 539

  Fly   482 DEECLRPGEPTDKTFLEKL-TQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGF 545
            ||||:.| :.||.|..:|| .|.|.:|.::   || |...|.......|.:.||||.|.|:...:
 Worm   540 DEECIVP-KATDLTLAQKLIDQHLGKHPNF---EK-PKPPKGKQAEAHFAMRHYAGTVRYNCLNW 599

  Fly   546 LDKNNDLLFRDLKETLSKAGN------GIVRNCFPEKELRSLKRPETAITQ-------------- 590
            |:||.|.| .|...|:.||..      .:.::...::|..:.....||..:
 Worm   600 LEKNKDPL-NDTVVTVMKASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFMTVSML 663

  Fly   591 FRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTY 655
            :|.|||.||.:|....|.:||||.||:.:.:.|.:..|||:|:...|::|.:|:.|.||..|..:
 Worm   664 YRESLNKLMTMLHSTHPHFIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLH 728

  Fly   656 ELFLERYKSLSKSTWPNYKGPGGPKAG----VQQLVKDLGWDEEKYRVGETKLF----------- 705
            ..|::||..|:..  .:..|....|.|    :.:|||:...:||.:|||.||:|
 Worm   729 PDFVQRYALLAAD--ESIIGKTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIVAHLED 791

  Fly   706 ----------------IRWPRTLFDTEDAYQ--EKKHEI-----AAIIQAHWKGLMQRRKYL--- 744
                            |||         .||  |:|..:     ..|||.:.:...:.|.::
 Worm   792 LRDQSLAQLITGLQAQIRW---------YYQTIERKRRVEKITALKIIQRNIRSWAELRTWVWFK 847

  Fly   745 ------------KLRAQVIIMQ---SYCRRKLAQQAAKKR--REAADKIRAFIKGFITRNDAPNG 792
                        |:.||...:|   :..:..:.|:..|||  :|.|:::.......:.:.:|..|
 Worm   848 LYGKVKPLVNSGKIEAQYEKLQETVATLKDTVVQEEEKKRQLQEGAERLNKETADLLAQLEASKG 912

  Fly   793 -----------FNEEFIANAKRMWLLRLAKELPT------------KVLDKSWPHAPGHCEEASG 834
                       .||:.:|...:  |...:|:|..            |:::........:|::...
 Worm   913 STREVEERMTAMNEQKVALEGK--LADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDL 975

  Fly   835 ILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPK--EHIQR 897
            .|.::.....|:.::::....:.||.:..:  .|:.|.:||          ||::..|  |.:|.
 Worm   976 SLRKVEAEKNAKEHQIRALQDEMRQQDENI--SKLNKERKN----------QEEQNKKLTEDLQA 1028

  Fly   898 VNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTL 962
            ..:   ....:.:||.:...:..|......|::                   ::|..:||   ..
 Worm  1029 AEE---QNLAANKLKAKLMQSLEDSEQTMEREK-------------------RNRADMDK---NK 1068

  Fly   963 TNHNDDLMVIRIPL-DLKKDKGD 984
            .....:|.:.:..| :|.|.|.|
 Worm  1069 RKAEGELKIAQETLEELNKSKSD 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	264/744 (35%)
		MYSc_Myo1	52..707	CDD:276829	261/727 (36%)
		Myosin_TH1	863..1035	CDD:283635	22/125 (18%)
myo-2	NP_510092.2	Myosin_N	31..68	CDD:280832
		Myosin_head	83..782	CDD:278492	261/704 (37%)
		MYSc_class_II	95..782	CDD:276951	261/700 (37%)
		Myosin_tail_1	876..1939	CDD:279860	42/255 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910