DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and hum-6

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_508420.1	Gene:	hum-6 / 180539	WormBaseID:	WBGene00002039	Length:	2098	Species:	Caenorhabditis elegans

Alignment Length:	802	Identity:	302/802 - (37%)
Similarity:	450/802 - (56%)	Gaps:	81/802 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAY 95
            :|.....||:|...|.::. |.|.:.||..|::|.|||.|.|.:||:||||..:.|||.|.::.|
Worm    56 MHPTSVQGVEDMCQLGDFH-ESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMY 119

  Fly    96 RNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEG 160
            :.|...|:||||||:.|||:.::..|.:.|.|:||||||:||||::|.||||:|..||..:.:|
Worm   120 KRKRIGELPPHIFAIADNAYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISGQHSWIE- 183

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
              .::|::||||||||||||.|||||||||||:|:.|:..|:..|..|..|||||||:|.|...|
Worm   184 --QQVLEANPVLEAFGNAKTIRNDNSSRFGKYIDVHFNESGSIEGAKIEQYLLEKSRIVTQSENE 246

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            ||:||||.||||.......||.|..|.| |.||..|...|....:||....:::.|:.|:...::
Worm   247 RNYHIFYCLLAGLSREEKSELELGTAAD-YYYLIQGKTLTAEGRDDAADLAEIRSAMRVLMINEQ 310

  Fly   291 EQREIFGIVASILHLGNVGFTEVEGNAKVNSRDL-----VVTAARLLGVNASELEAALTHRTIDA 350
            |...||.::||:||:||:.|.: ..|..:.|.|:     :|..|:||.::...|..|:|.:::..
Worm   311 EIGSIFKLLASLLHIGNIRFRQ-NTNDNMESVDVADPSTLVRIAKLLQLHEQNLLDAITTKSLVT 374

  Fly   351 RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIF 415
            |.:.|.|.||.:.|:.||||||||:|.:||..:|:|:|.::.  :...||...:|||||:|||.|
Worm   375 REERVISRLNGQQAVDARDALAKAIYGKLFIHIVRRVNDAIY--KPSQSRRTSIGILDIFGFENF 437

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISI 480
            :.|||||.||||.||.|||.|:....|.||.||..|.|.|..:::.||:...:||.::...|:|:
Worm   438 ESNSFEQLCINFANETLQQFFVHHVFKMEQKEYDEEHINWRHIKFVDNQATVDLIAQRPLNILSL 502

  Fly   481 LDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIK-KIMLRDEFRLVHYAGEVTYSVNG 544
            :|||.:.| :.||||.|.||         :..|.:...::: |..|:..|.:.|:||.|.|:..|
Worm   503 IDEESIFP-KGTDKTMLLKL---------HSTHGRNELYLQPKSELQRAFGVTHFAGNVFYNTRG 557

  Fly   545 FLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAI-TQFRASLNNLMDILMCKEPS 608
            ||:||.|....||...:|.:....:...|.:.|..:..|.:..: .|||.||..||..|....|.
Worm   558 FLEKNRDSFSADLSVLISSSKMPFLARLFDDIEYDTSSRKKVTVGNQFRRSLEQLMSQLTQTHPF 622

  Fly   609 YIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNY 673
            :|||||||:::.|.|.:.:|||.|::|.|:||.:::||:|:..|..|..|:.||:.|..|    .
Worm   623 FIRCIKPNEMKRALVMDRDLVLRQLRYSGMMETIKIRRSGYPIRHDYYPFVFRYRVLVSS----I 683

  Fly   674 KGPGGPKAGVQQLVKD-----LGWDEEKYRVGETKLFIRWPRTLFDTEDAYQ------------- 720
            :||.. :..:....|.     ||.:.: |::|:||:|::....|...::.|:
Worm   684 QGPVN-RIDLHDAAKKICHMILGTNAD-YQLGKTKVFLKDKHDLVLEQEYYRILKDKAIVIQKNV 746

  Fly   721 ---------EKKHEIAAIIQAHWKGLMQRRKYLK-----------------------LRAQVIIM 753
                     ||:.:.|..||..|:|..||::|.:                       ||..:|..
Worm   747 RRWLVRKDFEKQRQAAVTIQTAWRGFDQRKRYRQIISGFSRLQAVLRSRQLVSHYQTLRKTIIQF 811

  Fly   754 QSYCRRKLAQQAAKKRREAADK 775
            |:.||..|.::...::|:..:|
Worm   812 QAVCRGSLVRRQVGEKRKRGEK 833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	282/699 (40%)
		MYSc_Myo1	52..707	CDD:276829	275/666 (41%)
		Myosin_TH1	863..1035	CDD:283635
hum-6	NP_508420.1	MYSc	57..731	CDD:214580	282/697 (40%)
		MYSc_Myo7	76..720	CDD:276832	275/666 (41%)
		IQ	757..779	CDD:197470	8/21 (38%)
		MyTH4	929..1168	CDD:214535
		B41	1174..1388	CDD:214604
		FERM_B-lobe	1278..1378	CDD:271216
		FERM_C1_MyoVII	1382..1480	CDD:270019
		SH3	1481..1544	CDD:302595
		MyTH4	1624..1772	CDD:214535
		B41	1779..1993	CDD:214604
		FERM_B-lobe	1890..1985	CDD:271216
		FERM_C2_MyoVII	1989..2087	CDD:270020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910