Protein Alignment Myo61F and myo-3

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_506065.2
• Gene: myo-3 / 179676
• WormBaseID: WBGene00003515
• Length: 1969
• Species: Caenorhabditis elegans
• Alignment Length: 1072
• Identity: 337/1072 - (31%)
• Similarity: 526/1072 - (49%)
• Gaps: 170/1072 - (15%)

  Fly    48 YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTD 112
            :.:|.:.:||||.|:::.:||||.|...:.:||||:||||::..:|.:..|...|||||:|||:|
 Worm    96 FLNEASVLGNLKDRYKDLMIYTYSGLFCVVINPYKRLPIYSESVIKHFMGKRRNEMPPHLFAVSD 160

  Fly   113 NAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA------ACSGNQTTVEGVK-----DKLL 166
            .|:|:::::...|.:||:||||:||||.:|||:.:.|      |.||.:.. :|.|     ::::
 Worm   161 EAYRNMVQDKENQSMLITGESGAGKTENTKKVISYFAIVGATQAASGKEAK-DGKKGGTLEEQIV 224

  Fly   167 KSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIF 231
            ::||||||||||||.||:|||||||::...|...|...||:|.:|||||||||.|..|||.:|||
 Worm   225 QTNPVLEAFGNAKTVRNNNSSRFGKFIRTHFSGSGKLAGGDIEHYLLEKSRVVRQAPGERCYHIF 289

  Fly   232 YQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIF 296
            ||:::|.|.:|..:|:|...: ||.:.......|:..::|.:..:..|:|..::.|...|..:::
 Worm   290 YQIMSGNDPSLRGKLKLSNDI-TYYHFCSQAELTIEGMDDKEEMRLTQEAFDIMGFEDNETMDLY 353

  Fly   297 GIVASILHLGNVGFTE--VEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDVVTSPL 359
            ...|.|:|:|.:.|.:  .|..|:.:..:..:.||.:||:.|.|...|||...:....:.|....
 Worm   354 RSTAGIMHMGEMKFKQRPREEQAEPDGEEDALNAAAMLGIQAEEFLKALTKPRVRVGTEWVNKGQ 418

  Fly   360 NQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFC 424
            |.|...:|...||||:|.|:|.|::.|.|.:|.|||  ..|.:.:|:|||.|||||..|||||..
 Worm   419 NLEQVNWAVSGLAKAIYARMFKWIITRCNKTLDAKE--IERKHFIGVLDIAGFEIFDLNSFEQLW 481

  Fly   425 INFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPG 489
            |||.||:|||.|.......||:||:||||.|..:::..:...|..:.||..||||||||||:.|
 Worm   482 INFVNERLQQFFNHHMFVLEQEEYKREGIAWTFIDFGLDLQACIELIEKPLGIISILDEECIVP- 545

  Fly   490 EPTDKTFLEK-LTQKLAQHHHYVCHEKAP------AHIKKIMLRDEFRLVHYAGEVTYSVNGFLD 547
            :.||.|:.:| |.|.|.:|.::. ..|.|      ||         |.:|||||.|.|:...||:
 Worm   546 KATDMTYAQKLLDQHLGKHPNFQ-KPKPPKGKQGDAH---------FAIVHYAGTVRYNATNFLE 600

  Fly   548 KNNDLLFRDLKETLSK--AGNGIVRNCF-----PEKELRSLKRPETAITQ-------------FR 592
            ||.|.| .|....|.|  ..|.::.:.:     .|:...:.|..:||..:             :|
 Worm   601 KNKDPL-NDTAVALLKHSTDNSLMLDIWQDYQTQEEAAEAAKAGQTAGGKRGKSSSFATVSMIYR 664

  Fly   593 ASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYEL 657
            .||||||::|....|.:||||.||:.:.:.|.:..|||:|:...|::|.:|:.|.||..|..|..
 Worm   665 ESLNNLMNMLYQTHPHFIRCIIPNEKKASGVIDSALVLNQLTCNGVLEGIRICRKGFPNRMLYPD 729

  Fly   658 FLERYKSL----SKSTWPNYKGPGGPKAGVQQLVK---DLGWDEEKYRVGETKLFIRWPRTLFDT 715
            |..||..|    :|.:.|.       ||.|..|.|   |....:|:::|||||:|.: ...|...
 Worm   730 FKHRYAILAADAAKESDPK-------KASVGILDKISVDGNLTDEEFKVGETKIFFK-AGVLAKL 786

  Fly   716 EDAYQEKKHEIAAIIQAHWKGLMQ----RRKYLKLRAQVII---MQSYC------------RRKL 761
            ||...|....|..:.|:..:..:.    ||:|.:....:::   ::::|            :.|.
 Worm   787 EDLRDEILSRIVTMFQSRIRSYLAKAEVRRRYEQQTGLLVVQRNVRAWCTLRTWEWFKLFGKVKP 851

  Fly   762 AQQAAKKRR---EAADKIR----AFIKGFITRN-------DAPNGFNEEFI-----------ANA 801
            ..:|.|::.   |.|.||:    |..:|.|.|:       |.....|..|:           |..
 Worm   852 MLKAGKEQEAMGELAVKIQKLEEAVQRGEIARSQLESQVADLVEEKNALFLSLETEKANLADAEE 916

  Fly   802 KRMWLLRLAKELPTKVLDKSWPHAPGHCE------------------EASGILHRLHRLHLARIY 848
            :...|.:|...|.:|:.|     ..|..|                  |.|.....:..|.|:
 Worm   917 RNEKLNQLKATLESKLSD-----ITGQLEDMQERNEDLARQKKKTDQELSDTKKHVQDLELS--- 973

  Fly   849 RLKLTPQQK--RQFELKVLAE----------KVFKGKK----NNYASSVSTWFQEDRIPKEHIQR 897
             |:...|:|  |...::.|.:          |:.|.||    :|...:.....:||::  .|:::
 Worm   974 -LRKAEQEKQSRDHNIRSLQDEMANQDEAVAKLNKEKKHQEESNRKLNEDLQSEEDKV--NHLEK 1035

  Fly   898 VNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTL 962
            :.:.:....  ::|:......|..|...:...|.:....|.......:..||||     .::.||
 Worm  1036 IRNKLEQQM--DELEENIDREKRSRGDIEKAKRKVEGDLKVAQENIDEITKQKH-----DVETTL 1093

  Fly   963 TNHNDDLMVIRIPLDLKKDKGDLILIIPRIIE 994
            ....:||......|   .:...:|..:.|:|:
 Worm  1094 KRKEEDLHHTNAKL---AENNSIIAKLQRLIK 1122

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	270/701 (39%)
		Myosin_TH1	863..1049	CDD:461801	26/146 (18%)
myo-3	NP_506065.2	COG5022	32..1420	CDD:227355	337/1072 (31%)
		MYSc_class_II	100..779	CDD:276951	270/701 (39%)
		SMC_prok_B	1182..1933	CDD:274008