Protein Alignment Myo61F and Myo5b

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_006525777.1
• Gene: Myo5b / 17919
• MGIID: 106598
• Length: 1849
• Species: Mus musculus
• Alignment Length: 1065
• Identity: 353/1065 - (33%)
• Similarity: 550/1065 - (51%)
• Gaps: 142/1065 - (13%)

  Fly    15 TKDYI--DFNSQLKMETGLHERDRAGVQ----------DFVLLEN------YQSEEAFIGNLKKR 61
            ||||.  |.:.||::|..........||          |.::.||      :..|.|.:.|||.|
Mouse    28 TKDYKEGDKSLQLRLEDDTILEYPVDVQNNQVPFLRNPDILVGENDLTALSHLHEPAVLHNLKVR 92

  Fly    62 FQE-DLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQ 125
            |.| :.||||.|.||:::|||:|||||..|.:.||..::..:|.||||||.:.|::.:..:.:.|
Mouse    93 FLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDMDPHIFAVAEEAYKQMARDEKNQ 157

  Fly   126 CVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFG 190
            .:::|||||:|||.::|..:::.|...|:.:.. .:::|:|.|:|::||.|||||.|||||||||
Mouse   158 SIIVSGESGAGKTVSAKYAMRYFATVGGSASDT-NIEEKVLASSPIMEAIGNAKTTRNDNSSRFG 221

  Fly   191 KYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTY 255
            |:::|.||.|...||.|:..|||||||||.|...|||:||||||.|.|.....:||.|..|.| :
Mouse   222 KFIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELALTCAED-F 285

  Fly   256 SYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGF-TEVEGNA-K 318
            .|...|.|.|:..:||||.|::.:||||::......|..||.|:|||||||:|.. :|.:|:: .
Mouse   286 FYTAHGGNTTIEGVNDADDFEKTRQALTLLGVRDSHQISIFKIIASILHLGSVEIQSERDGDSCS 350

  Fly   319 VNSRD-LVVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSW 382
            ::.:| .:.....|||:..|::|..|.||.:....:.....::.:..:.|||||||.:|.:||||
Mouse   351 ISPQDEHLSNFCSLLGIEHSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHIYAQLFSW 415

  Fly   383 LVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDE 447
            :|:.:|   :|..|...:::.:|:|||||||.|:.|||||||||:.||||||.|.....|.||:|
Mouse   416 IVEHIN---KALHTSLKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFKLEQEE 477

  Fly   448 YRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVC 512
            |.:|.|.|..::::||:...:|||.| .||:.:|||||..| :.||:.:.:||.::.:...|:.
Mouse   478 YMKEQIPWTLIDFYDNQPCIDLIEAK-LGILDLLDEECKVP-KGTDQNWAQKLYERHSNSQHFQ- 539

  Fly   513 HEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDL-------------------LFRDLK 558
                    |..|....|.:.|:|.:|.|..:|||:||.|.                   ||.|.|
Mouse   540 --------KPRMSNTAFIVNHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDK 596

  Fly   559 ETL-------SKAGNGI-VRNCFPEKELRSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIKP 615
            ::.       :::.:.| ||:..|..::.:.:..::...|||.|||.||:.|....|.|:|||||
Mouse   597 DSAPATNTAKNRSSSKINVRSSRPLIKVPNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKP 661

  Fly   616 NDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSL-SKSTWPNYKGPGGP 679
            ||.:....|:.:..:.|::..|::|.:|:..||:..|.||..|..||:.| .|....|.......
Mouse   662 NDEKLPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVLMKKRELTNTDKKNIC 726

  Fly   680 KAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYL 744
            |:.::.|:|    |.:|::.|.||:|.|..:..: .|....:|..|...:||...:|.:||.||.
Mouse   727 KSVLESLIK----DPDKFQFGRTKIFFRAGQVAY-LEKLRADKFREATIMIQKSVRGWLQRVKYR 786

  Fly   745 KLRAQVIIMQSYCRRKLAQQAA-------------------KKRR------EAADKIRAFIKGFI 784
            :|||..:.:|.:||..||::.|                   |.||      .|...|::|.:...
Mouse   787 RLRAATLSLQRFCRGYLARRLAEHLRRTRAAIVFQKQYRMLKARRAYRRVCRATVIIQSFTRAMF 851

  Fly   785 TRNDAPNGFNEE---FIANAKRMWLLR---LAKELPTKVLDKSWPHAPGHCE------EASGILH 837
            .|.:......|.   .|....|.|:.|   |.:.....|:..::.......|      ||....|
Mouse   852 VRRNYRQVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQCAFRRLKARQELKALKIEARSAEH 916

  Fly   838 RLHRLHLA---RIYRL--KLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKE--HI 895
             |.||::.   ::.:|  |:..|.|   |.|.|:|:: ....:::|..|      :::.||  |.
Mouse   917 -LKRLNVGMENKVVQLQRKIDDQNK---EFKTLSEQL-SAVTSSHAVEV------EKLKKELAHY 970

  Fly   896 QRVNDFVASTFGSEQLKYQSFCTKF-----------DRHGYKS---RDRFILLSNKAIYVLDGKT 946
            |:..:  |.|....|.:.||..|:.           |.|..::   |.|...|.::...:.|.|.
Mouse   971 QQNQE--ADTSLQLQEEVQSLRTELQKAHSERRVLEDAHNKENGELRKRVADLEHENALLKDEKE 1033

  Fly   947 YKQKHRLPLDKIDFTLTNHNDDLMV 971
            |.....|...|.:.:.::..::|::
Mouse  1034 YLNNQILCQSKAESSQSSVEENLLM 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	267/686 (39%)
		Myosin_TH1	863..1049	CDD:461801	26/125 (21%)
Myo5b	XP_006525777.1	COG5022	11..>1268	CDD:227355	353/1065 (33%)
		MYSc_Myo5	83..750	CDD:276831	267/686 (39%)
		EnvC	1202..>1441	CDD:443969
		Myo5b_CBD	1475..1846	CDD:271261