Protein Alignment Myo61F and Myo1c

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001357540.1
• Gene: Myo1c / 17913
• MGIID: 106612
• Length: 1063
• Species: Mus musculus
• Alignment Length: 1039
• Identity: 535/1039 - (51%)
• Similarity: 712/1039 - (68%)
• Gaps: 28/1039 - (2%)

  Fly    24 QLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYT 88
            ::.||:.|..|||.||||||||||:.||.|||.||::||:|:|||||||.||:|||||:.|.||:
Mouse    33 RVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYS 97

  Fly    89 DDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG 153
            ..|::.||...|||:|||:|||.|..:|:|..|.|.|.|:||||||:|||||:|::|||.|....
Mouse    98 RQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCP 162

  Fly   154 NQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRV 218
            .......|:|:||:|||||||||||||.|||||||||||||:||||||||:||:||:||||||||
Mouse   163 APERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRV 227

  Fly   219 VAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALT 283
            |.|..||||||:|||||.|.:|..|:.|.|||...:|.||..|....|:.|||...:|.:::||:
Mouse   228 VHQNHGERNFHVFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVMRKALS 292

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGF-TEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRT 347
            |||||::|..::..||||:|||||:.| .:.:.||:|.:.:.:....|||||..:.|..|||||.
Mouse   293 VIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRK 357

  Fly   348 IDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRA---SRNNVMGILDI 409
            |.|:|:.:.||||.|.|.|||||||||||.|.|:|||:::|.||.:|:..:   ....|:|:|||
Mouse   358 IIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDI 422

  Fly   410 YGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKH 474
            ||||:||.|||||||||:||||||||||||||||||:||..|||.|.||:||:||:||:|:|||.
Mouse   423 YGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKF 487

  Fly   475 KGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539
            ||||||||||||||||.||.||||||...:..|.|::.|:.|....:|.:.|.||||:|||||||
Mouse   488 KGIISILDEECLRPGEATDLTFLEKLEDTVKPHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVT 552

  Fly   540 YSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMC 604
            |||.||||||||||||:||||:..:.|.|:..||.:.||...|||||..|||:.||..|::||..
Mouse   553 YSVTGFLDKNNDLLFRNLKETMCSSMNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRS 617

  Fly   605 KEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKST 669
            |||:|||||||||.:....|::.|:.|||||||||||||||||||||||.||.||:|||||...|
Mouse   618 KEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPET 682

  Fly   670 WPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHW 734
            ||.:  .|.|:.||..||:.||:..|:|::|.||:|||:|:|||.|||:.:.::..:|..|||.|
Mouse   683 WPMW--AGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAW 745

  Fly   735 KGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIA 799
            :|...|:|:|:::...|.:||:.|..|.::.|.||:.||..||..|:|||.|:......|..|:.
Mouse   746 RGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHSPRCPENAFFLD 810

  Fly   800 NAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKV 864
            :.:..:||.|.::||..|||.|||..|....|||.:|..|...::...|...::|:.|:|.:.|.
Mouse   811 HVRASFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKA 875

  Fly   865 LAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRD 929
            :|.::|||||:||..||...|...|:..|.|   :..|..:.|||.::|.....|:||.|||.|.
Mouse   876 VASEIFKGKKDNYPQSVPRLFISTRLGTEEI---SPRVLQSLGSEPIQYAVPVVKYDRKGYKPRP 937

  Fly   930 RFILLSNKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHNDDLMVIRIPLDLKKDKGDLILI 988
            |.:||:..|:.:::....||       :||:      ::::.:|.|.|:.:..:..|.|||::|.
Mouse   938 RQLLLTPSAVVIVEDAKVKQ-------RIDYANLTGISVSSLSDSLFVLHVQREDNKQKGDVVLQ 995

  Fly   989 IPRIIEFSTYIIDTVGTASIVSIVDRN--SLEHNVVKGKGGVIDIQTGAEPGVVRDK-GHLVII 1049
            ...:||..|   .|..:|..|:.::.|  |:......|:.|:||..:|:|..:.:.| |||.::
Mouse   996 SDHVIETLT---KTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVV 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	398/658 (60%)
		Myosin_TH1	863..1049	CDD:461801	61/194 (31%)
Myo1c	NP_001357540.1	MYSc_Myo1	62..718	CDD:276829	398/657 (61%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		14/21 (67%)
		IQCG	751..781	CDD:467744	10/29 (34%)
		Myosin_TH1	874..1055	CDD:461801	61/193 (32%)