Protein Alignment Myo61F and Myo1b

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: XP_006495827.1
• Gene: Myo1b / 17912
• MGIID: 107752
• Length: 1138
• Species: Mus musculus
• Alignment Length: 1090
• Identity: 466/1090 - (42%)
• Similarity: 656/1090 - (60%)
• Gaps: 148/1090 - (13%)

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||.|.||||.. :||.||.||||||..:.||||||.|:||||||:.||||:.:.|:.|||::|||
Mouse    16 GVGDMVLLEPL-NEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYE 79

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLK 167
            :.|||||::|.|:|||.::::.||:||:||||:|||||||.|:.::||..|....|..||::||:
Mouse    80 LSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQ 144

  Fly   168 SNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFY 232
            |||||||||||||.||||||||||||||:|||||.|:||.|.||||||||||.|..||||||:||
Mouse   145 SNPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFY 209

  Fly   233 QLLAGADEALLQELRLERALDTYSYLT-DGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIF 296
            |||:||.|.||.:|:|||....|:||: |  :..|..::||.:|:.|:.|:.::.|...|...:.
Mouse   210 QLLSGASEELLYKLKLERDFSRYNYLSLD--SAKVNGVDDAANFRTVRNAMQIVGFLDHEAEAVL 272

  Fly   297 GIVASILHLGNVGF---TEVEG--NAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDVVT 356
            .:||::|.|||:.|   :.|.|  .:|:..::.:.....|..::...||.|.:.||::|:.:.|:
Mouse   273 EVVAAVLKLGNIEFKPESRVNGLDESKIKDKNELKEICELTSIDQVVLERAFSFRTVEAKQEKVS 337

  Fly   357 SPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQK--NS 419
            :.||...|.||||||||.:|.|||||||.|:|.|::| :|:. |..|||:|||||||||:.  ||
Mouse   338 TTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKA-QTKV-RKKVMGVLDIYGFEIFENADNS 400

  Fly   420 FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEE 484
            ||||.||:|||||||:|||||||.||:||.||.|||..::||:|.:||:|||....||:::||||
Mouse   401 FEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENNTNGILAMLDEE 465

  Fly   485 CLRPGEPTDKTFLEKLTQKLAQHHHYVCH-EKAPAHIKKIMLRDE-FRLVHYAGEVTYSVNGFLD 547
            |||||..||:||||||.|..|.|.|:... .|....:....|... ||:.||||:|.|.|.||:|
Mouse   466 CLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAGKVLYQVEGFVD 530

  Fly   548 KNNDLLFRDLKETLSKAGNGIVRNCFPEKELR--SLKRPETAITQFRASLNNLMDILMCKEPSYI 610
            ||||||:|||.:.:.|||:.::::.|||....  :||||.||.:||:||:..||..|..|.|:||
Mouse   531 KNNDLLYRDLSQAMWKAGHSLIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLMRNLQTKNPNYI 595

  Fly   611 RCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKG 675
            |||||||.:.|::||:.||.||::||||:||:||||||:|:|:.||..|||||.|.|.|||::||
Mouse   596 RCIKPNDKKAAHIFNESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKG 660

  Fly   676 PGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKG---- 736
            |.  ::||:.|..:|....|::..|.:|:|||.|||||..||..:::..::|.:||..::|
Mouse   661 PA--RSGVEVLFNELEIPVEEHSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATLIQKIYRGWKCR 723

  Fly   737 ----LM---------------QRRKYLKLRAQVIIMQSYCR----RKLAQQAAKKRR--EAADKI 776
                ||               |:::|.::::..:::|||.|    ||:.::...::|  |||..|
Mouse   724 THFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKHQKRCKEAATTI 788

  Fly   777 RAFIKGFITR-------NDAPN------------------------------------------- 791
            .|:..|...|       ::|.|
Mouse   789 AAYWHGTQARRELRRLKDEARNKHAIAVIWAYWLGSKARRELKRLKEEARRKHAVAVIWAYWLGL 853

  Fly   792 ----GFNEEFIANAKR------------MWLLRLAKELPT-KVLDKSWPHAP------GHCEEAS 833
                .:.:.|.|||.:            .:||.:..::|: ..:||:||..|      .|.|
Mouse   854 KVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPYLFLDSTHKE--- 915

  Fly   834 GILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQE-----DRIPKE 893
              |.|:..|...:.||.:.|.|||..:|.|:.|.::||.||..|.|||...||.     ::.||
Mouse   916 --LKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQGAYLEINKNPK- 977

  Fly   894 HIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPL-DK 957
             .:::.|.:     .|::.......|.:|...||..|..||:|..:.:.|.|:.:.|..:|| |.
Mouse   978 -YKKLKDAI-----EEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKSGQIKSEVPLVDV 1036

  Fly   958 IDFTLTNHNDDLMVIRIPLDLKK-----DKGDLILIIPRIIEFSTYIIDT 1002
            ...::::.||....:.    ||:     .|||.:.....:||.:|.:..|
Mouse  1037 TKVSMSSQNDGFFAVH----LKEGSEAASKGDFLFSSDHLIEMATKLYRT 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	360/666 (54%)
		Myosin_TH1	863..1049	CDD:461801	41/151 (27%)
Myo1b	XP_006495827.1	MYSc_Myo1	29..690	CDD:276829	360/666 (54%)
		IQ	751..773	CDD:197470	6/21 (29%)
		Myosin_TH1	943..1120	CDD:461801	41/151 (27%)