Protein Alignment Myo61F and Myh3

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001093105.1
• Gene: Myh3 / 17883
• MGIID: 1339709
• Length: 1940
• Species: Mus musculus
• Alignment Length: 1080
• Identity: 326/1080 - (30%)
• Similarity: 520/1080 - (48%)
• Gaps: 179/1080 - (16%)

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:| .:.:|.|.:.|||.|:...:||||.|...::|||||.||:|..:.|..||.|...|.
Mouse    88 IEDMAML-THLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEVVDGYRGKKRQEA 151

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA--ACSGN-----QTTVEG- 160
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|  |.:|:     .:.::|
Mouse   152 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGDLAKKKDSKMKGT 216

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
            ::|:::.:||:|||||||||.||||||||||::.|.|...|.....:|..||||||||..|:..|
Mouse   217 LEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAE 281

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            |::|||||:|:.....|::.|.:......|.:::.| ...|..|:||:.......|:.::.||.|
Mouse   282 RSYHIFYQILSNKKPELIELLLITTNPYDYPFISQG-EILVASIDDAEELLATDSAIDILGFTPE 345

  Fly   291 EQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGD 353
            |:..::.:..:::|.||:.|.:.  |..|:.:..::....|.|:|:|:|:|..||....:....:
Mouse   346 EKSGLYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNE 410

  Fly   354 VVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKN 418
            .||.....:...:|.:||:|:||::||.|:|.|:|   |..:|:..|.:.:|:|||.|||||:.|
Mouse   411 YVTKGQTVDQVHHAVNALSKSVYEKLFLWMVTRIN---QQLDTKLPRQHFIGVLDIAGFEIFEYN 472

  Fly   419 SFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDE 483
            |.||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||.|||:|
Mouse   473 SLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEE 537

  Fly   484 ECLRPGEPTDKTFLEKL-TQKLAQHHHY----VCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVN 543
            ||:.| :.||.:|..|| .|.|.:.:::    |...||.||         |.||||||.|.|||:
Mouse   538 ECMFP-KATDTSFKNKLYDQHLGKSNNFQKPKVVKGKAEAH---------FSLVHYAGTVDYSVS 592

  Fly   544 GFLDKNNDLLFRDLKETLSKAGNGIVRNCFP----------EKELRSLKRP--ETAITQFRASLN 596
            |:|:||.|.|...:.....|:.|.::.:.:.          :|::...|..  :|....||.:||
Mouse   593 GWLEKNKDPLNETVVGLYQKSSNRLLAHLYATFATTDADGGKKKVAKKKGSSFQTVSALFRENLN 657

  Fly   597 NLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLER 661
            .||..|....|.::|||.||:.:|.......|||||::..|::|.:|:.|.||..|..|..|.:|
Mouse   658 KLMSNLRTTHPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQR 722

  Fly   662 YKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEI 726
            |:.|:.|..|..:.....|| .::|:..:..|..:|:.|.||:|.: ...|...|:...|:..::
Mouse   723 YRVLNASAIPEGQFIDSKKA-CEKLLASIDIDHTQYKFGHTKVFFK-AGLLGTLEEMRDERLAKL 785

  Fly   727 AAIIQAHWKGLMQRRKYLKL--RAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDA 789
            ....||..:|.:.|.::.|:  |.:.|....|..|...........:...||:..:|...|..:.
Mouse   786 ITRTQAVCRGFLMRVEFQKMMQRRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPLLKSAETEKEM 850

  Fly   790 PNGFNEEF--------IANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLAR 846
            .. ..|||        .:.|||       |||..|
Mouse   851 AT-MKEEFQKTKDELAKSEAKR-------KELEEK------------------------------ 877

  Fly   847 IYRLKLTPQQKRQFELKVLAE------------KVFKGKKNNYASSVSTWFQEDRIPKEHIQRVN 899
               |....|:|...:|:|.||            ::.|.|           ||.:...||..:|..
Mouse   878 ---LVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAK-----------FQLEAKIKEVTERAE 928

  Fly   900 D--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSRDRFI------LLSNKAIY 940
            |  .:.:...:::.|.:..|::.                ::|..:::.:.:      |....|..
Mouse   929 DEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELAGLDETIAKL 993

  Fly   941 VLDGKTYKQKHRLPLD-------------KIDFTLTNHNDDL-------MVIRIPLDLKKDK--G 983
            ..:.|..::.|:..||             |:...|....|||       ..:|:.|:..|.|  |
Mouse   994 TREKKALQEAHQQTLDDLQAEEDKVNSLSKLKSKLEQQVDDLESSLEQEKKLRVDLERNKRKLEG 1058

  Fly   984 DLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023
            ||.|....|::...               |:..|:..:.|
Mouse  1059 DLKLAQESILDLEN---------------DKQQLDERLKK 1083

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	261/707 (37%)
		MYSc_Myo1	52..707	CDD:276829	256/681 (38%)
		Myosin_TH1	863..1035	CDD:283635	37/219 (17%)
Myh3	NP_001093105.1	Myosin_N	35..73	CDD:367160
		MYSc_Myh3	100..767	CDD:276878	256/681 (38%)
		Actin-binding. /evidence=ECO:0000250	656..678		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	758..772		4/14 (29%)
		Myosin_tail_1	847..1924	CDD:366712	51/304 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1260..1289

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000