DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myh11

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006521906.1	Gene:	Myh11 / 17880	MGIID:	102643	Length:	1979	Species:	Mus musculus

Alignment Length:	1104	Identity:	336/1104 - (30%)
Similarity:	540/1104 - (48%)	Gaps:	190/1104 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 SEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNA 114
            :|.:.:.||::|:...|||||.|...:.|||||.||||::..|..|:.|..:||||||:|:.|.|
Mouse    97 NEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKYLPIYSEKIVDMYKGKKRHEMPPHIYAIADTA 161

  Fly   115 FRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKD---------------- 163
            :||::::...|.:|.:||||:||||.:|||:|::|..:.:.   :|.||
Mouse   162 YRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSH---KGKKDSSITQGPSFAYGELEK 223

  Fly   164 KLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNF 228
            :||::||:|||||||||.:|||||||||::.|.||..|..:|.||..|||||||.:.|...||.|
Mouse   224 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTF 288

  Fly   229 HIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQR 293
            ||||.|||||.|.:..:|.|| :.::|::|::|. ..:....|.:.|::..:|::::.|.:|||.
Mouse   289 HIFYYLLAGAKEKMKSDLLLE-SFNSYTFLSNGF-VPIPAAQDDEMFQETLEAMSIMGFNEEEQL 351

  Fly   294 EIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAAR----LLGVNASELEAALTHRTIDARGDV 354
            .|..:|:|:|.|||:.|.:.....:.:..|  .|||:    |:|:|.::...|:....|....||
Mouse   352 AILKVVSSVLQLGNIVFKKERNTDQASMPD--NTAAQKVCHLVGINVTDFTRAILTPRIKVGRDV 414

  Fly   355 VTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNS 419
            |.....:|.|.:|.:|||||.|:|||.|::.|:|.:|.  :|.....:.:|||||.|||||:.||
Mouse   415 VQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALD--KTHRQGASFLGILDIAGFEIFEVNS 477

  Fly   420 FEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVICNLIEEKHK--GIISIL 481
            |||.|||:.||||||||.......||:||:||||||..::: .|.:....|||..:.  |::::|
Mouse   478 FEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALL 542

  Fly   482 DEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFL 546
            ||||..| :.|||:|:|||..:...|..:    :.|..:|.   :.||.::||||:|.|:.:.:|
Mouse   543 DEECWFP-KATDKSFVEKLCSEQGNHPKF----QKPKQLKD---KTEFSIIHYAGKVDYNASAWL 599

  Fly   547 DKNNDLLFRDLKETLSKAGNGIVRNCF---------------PEKELRSLKRPETAITQ-----F 591
            .||.|.|..::...|:.:.:..|.:.:               .|..|.|..:.:..:.:     :
Mouse   600 TKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLY 664

  Fly   592 RASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYE 656
            :..|..||..|....|:::|||.||..:.:...:..|||.|::..|::|.:|:.|.||..|..::
Mouse   665 KEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQ 729

  Fly   657 LFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQE 721
            .|.:||:.|:.:..|  ||....|.....::|.|..|...||:|::|:|.| ...|...|:....
Mouse   730 EFRQRYEILAANAIP--KGFMDGKQACILMIKALELDPNLYRIGQSKIFFR-TGVLAHLEEERDL 791

  Fly   722 KKHEIAAIIQAHWKGLMQRRKYLKLRAQVI---IMQSYC-------------------------R 758
            |..::....||..:|.:.|:.:.|.:.|:.   ::|..|                         |
Mouse   792 KITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTR 856

  Fly   759 RKLAQQA----AKKRREAADKIRAFIKGFITRN----DAPNGFNEEFIANAKRMWLLRLAKELPT 815
            ::...||    .:|.:|...|....:|....::    :......|:..|..:   |...|:|:..
Mouse   857 QEEEMQAKEEEMQKIKERQQKAETELKELEQKHTQLAEEKTLLQEQLQAETE---LYAEAEEMRV 918

  Fly   816 KVLDKSWPHAPGHCEEASGILHRLH--------RLHLARIYRLKLTPQ---------------QK 857
            ::..|.        :|...|||.:.        |....:..|.|:..|               ||
Mouse   919 RLAAKK--------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975

  Fly   858 RQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEH---IQRVNDFVASTFGSEQ--------- 910
            .|.| ||.||...|..:::......   |..::.||.   .:||:|...:....|:
Mouse   976 LQLE-KVTAEAKIKKLEDDILVMDD---QNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLK 1036

  Fly   911 LKYQSFCTKFD---RHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHND--DL- 969
            .|::|..::.:   :...|||.               :..|.|.:|..|..||    |..  ||
Mouse  1037 SKHESMISELEVRLKKEEKSRQ---------------ELEKLKRKLEGDASDF----HEQIADLQ 1082

  Fly   970 -MVIRIPLDLKKDKGDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQ 1032
             .:..:.:.|.|.:.:|...:.|:.|               .|..:|:....:.:.:|.:.|:|
Mouse  1083 AQIAELKMQLAKKEEELQAALARLDE---------------EIAQKNNALKKIRELEGHISDLQ 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	266/712 (37%)
		MYSc_Myo1	52..707	CDD:276829	262/697 (38%)
		Myosin_TH1	863..1035	CDD:283635	36/189 (19%)
Myh11	XP_006521906.1	Myosin_N	33..71	CDD:367160
		MYSc_class_II	99..778	CDD:276951	262/697 (38%)
		Myosin_tail_1	855..1935	CDD:366712	61/326 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000