Protein Alignment Myo61F and hum-8

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001294574.1
• Gene: hum-8 / 176872
• WormBaseID: WBGene00002041
• Length: 1279
• Species: Caenorhabditis elegans
• Alignment Length: 1076
• Identity: 306/1076 - (28%)
• Similarity: 532/1076 - (49%)
• Gaps: 154/1076 - (14%)

  Fly    14 DTKDYIDFNSQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISV 78
            |::.:::.|.||.                     :.:|...:.|::.|:|...||:|:..:|||:
 Worm   126 DSRRHVEDNCQLM---------------------HLNEATLLNNIRLRYQNGKIYSYVANILISI 169

  Fly    79 NPYKQLP-IYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASK 142
            |||:.:. .|:...:|.||.|...:..|||||:.|.::|.:|...:.|.:::|||||:||||:.|
 Worm   170 NPYQTIDGFYSLQKIKEYRGKSLGQKEPHIFAIADKSYREMIRHRKSQSIIVSGESGAGKTESQK 234

  Fly   143 KVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGN 207
            .||:::  |....:....::.:||::||:|||||||||.||:|||||||::.|.|...|...||.
 Worm   235 AVLRYL--CENWGSGAGEIQKRLLETNPILEAFGNAKTLRNNNSSRFGKFVQIHFADTGNVAGGY 297

  Fly   208 ILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGL--------NG 264
            :.:||||.||:..|..||||:||||||:||:...|.:.|.|.:. :.::||..|.        :|
 Worm   298 VSHYLLETSRICRQAAGERNYHIFYQLIAGSSPELFKFLALGQP-NQFNYLKRGFIGFFTHPSSG 361

  Fly   265 TVTRI----------------NDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTE- 312
            |.::|                :|...|::::.||.:...:::|...|:..:|:|||||||.|.|
 Worm   362 TTSKIPKNRLSDPKFTQDSMVDDFSDFQRLEYALKLTGLSEQEIHFIWTTIAAILHLGNVEFEES 426

  Fly   313 ---VEGNAKV---NSRDLVVTAARLLGVNASELEAALTHRTID-----ARGDVVTSPLNQELAIY 366
               ..|..||   :.:|| :.||||||:...||:..|..|.:.     |||.::..||....|..
 Worm   427 LDDSRGGCKVFNGSEQDL-IQAARLLGLETMELKMGLCARIMQTTKGGARGTLIRVPLKPHEACS 490

  Fly   367 ARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEK 431
            .||||:||:|.:||.|||.|:|.|:..:::    .|.:|:||:.|||.:.|||||||||||||||
 Worm   491 GRDALSKAIYSKLFDWLVSRINDSIPFEKS----TNFVGVLDVAGFEFYAKNSFEQFCINFCNEK 551

  Fly   432 LQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTF 496
            ||..|.:..|:.||:.|.:||:....:|:.||:....|.|.|..|:..:||||...| ....|:|
 Worm   552 LQNFFNQRILREEQELYEKEGLNVRKIEFIDNQDCIELFELKGNGLFDLLDEEAKFP-TSNYKSF 615

  Fly   497 LEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLV-HYAGEVTYSVNGFLDKNNDLLFRDLKET 560
            .::..::..:|.......|:.....:.:..||..|: ||||.|.|....|::||:|||...|:..
 Worm   616 TKRAHEENRKHFRLDTPRKSKVKSHRELRDDEGLLIRHYAGSVCYETKHFVEKNDDLLHNSLQIL 680

  Fly   561 LSKAGNGIVRNCF-----PEK-ELRSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQ 619
            :.::...::.:.|     |.| :|::|    :...:|:..|:.|:..|......::||||||:..
 Worm   681 IEQSTIRLLVSLFGSTAYPTKSKLKAL----SVGAKFKNQLSTLLIKLESTGTHFVRCIKPNNQM 741

  Fly   620 TANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTY-ELFLERYKSLSKSTWPNYKGPGGPKAGV 683
            ....|:...:|.|::..|:...|::.:.||..|..: :|:....|.|     |.......|:...
 Worm   742 IPFEFDGSAILSQLQCAGMTSVLKLMQDGFPSRTGFGDLYACYQKKL-----PPKLSKLDPRMFC 801

  Fly   684 QQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQ--------AHWKGLMQR 740
            :.|.:.||.|:..::.|.||:|.|..: ..:.:...::....:.::||        |.||    :
 Worm   802 KCLFRALGLDQHDFQFGLTKVFFRAGK-FAEFDQMMKQDPETMTSLIQKVNEWLVGARWK----Q 861

  Fly   741 RKY-----LKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIAN 800
            .:|     :||           :.|:|.::|:..|     :::..:|::||    ..|:.:....
 Worm   862 SQYAVWSVIKL-----------KNKIAWRSAQVTR-----LQSIARGYLTR----QRFSRQIALY 906

  Fly   801 AKRMWLLRLAKELPTKVLDKSWPHAPG-HCEEASGILHRLHRLHLARIYRLKLTPQQKRQFE--- 861
            .|.:.||:.:||: .|:|.:...|:.. :...|...:..|.:|    :..:|||......||
 Worm   907 RKSVALLKNSKEI-EKILFRLNEHSRAKYTSSAHSTIRDLEKL----VSHIKLTTSANDHFEKAE 966

  Fly   862 ------LKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKF 920
                  :|.:...:...||...:..::. .:..|...|..:|: :..|......|.:.:....:.
 Worm   967 NAYEHYVKRVDSMIADLKKQQKSDELAE-IERKRRESEEKERL-EIEAKKEAERQREIKRKLEEQ 1029

  Fly   921 DRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTN---HNDDLMVIRIPLDLKKDK 982
            .::..|..:.:::   ..|:....:|.|::.....:|:|..::|   ..|.:.:|...::::...
 Worm  1030 QQNAQKEHENYLI---SEIHKAAEETEKKRQNEEKEKLDKMVSNRLAEADGVALISSKMEIEPSS 1091

  Fly   983 GDLILIIPRIIEFS------TYIIDTVGTASIVSIV 1012
            |....   |..::.      .|:.||:.|:..::::
 Worm  1092 GSATF---RDGKYDVGGCSFAYLRDTINTSMDINLL 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	245/699 (35%)
		Myosin_TH1	863..1049	CDD:461801	23/159 (14%)
hum-8	NP_001294574.1	MYSc_Myo6	143..825	CDD:276833	245/699 (35%)
		CBD_MYO6-like	836..987	CDD:409646	35/179 (20%)
		tolA_full	983..>1076	CDD:274303	14/97 (14%)
		MyUb_Myo6	1099..1139	CDD:439319	4/26 (15%)
		Myosin-VI_CBD	1180..1276	CDD:465157