DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and hum-5

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_497809.1	Gene:	hum-5 / 175521	WormBaseID:	WBGene00002038	Length:	1017	Species:	Caenorhabditis elegans

Alignment Length:	1071	Identity:	420/1071 - (39%)
Similarity:	612/1071 - (57%)	Gaps:	120/1071 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 METGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDH 91
            |..|.|:.:..||:|.|||..... ::.:.||:.|||:..||||||:||::||||:||.||....
Worm     1 MSYGGHDPNGYGVEDLVLLSTIDL-KSVVQNLQLRFQKGRIYTYIGEVLVAVNPYRQLGIYEKST 64

  Fly    92 VKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG--N 154
            |..|:.:..||..||:||:.|.|:||:....|..|::||||||:||||.||.:::::||.:.  .
Worm    65 VDQYKGREIYERAPHVFAIADAAYRSMKRFGRDSCIVISGESGAGKTETSKIIMKYLAAITNVRQ 129

  Fly   155 QTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVV 219
            |..:|.||:.||:||.:|||||.|||.||||||||||||.|.||:.|.|:||||.||||||||||
Worm   130 QGEIERVKNVLLRSNCILEAFGCAKTTRNDNSSRFGKYMHINFDYDGDPVGGNISNYLLEKSRVV 194

  Fly   220 AQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQAL-T 283
            .|..||||||:||||:.|.|:.||::..|.:....|.:|..|.:..|..|||:..|.:||.|| :
Worm   195 RQQEGERNFHVFYQLVNGGDDGLLRQFGLTKDAKQYYFLNQGQSHKVASINDSRDFAEVQTALRS 259

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGFTEVE---GNAKVNSRDLVVTAARLLGVNASELEAALTH 345
            :..|.|::...::.::|.::|||||.|.:.|   |...:..:..:..|||.|.|...||..:|:.
Worm   260 IHTFDKQDVESMWSVIAGLIHLGNVRFIDGENSSGAVHIAEKAALQNAARCLNVTPDELAKSLSS 324

  Fly   346 RTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLN--ISLQAKETRASRNNVMGILD 408
            :.:.|.||:|....:...|.|.|||||||:|:|||||:|.::|  ||:| ..:|.|:::|:|:||
Worm   325 QVVAAHGDIVKKQHDVNAAYYTRDALAKALYERLFSWMVSKVNEAISVQ-NSSRYSKSHVIGVLD 388

  Fly   409 IYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEK 473
            |||||||..|||||.|||:||||||||||||.||.||:||.||||:|:.:|||:|||||:|:|..
Worm   389 IYGFEIFGTNSFEQLCINYCNEKLQQLFIELVLKQEQEEYEREGIKWVKIEYFNNKVICDLVEIP 453

  Fly   474 HKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEV 538
            ..||:|||||.|...|..|||.||.:|.:||..|.||.......:  .|.|..:||::.||||:|
Worm   454 RTGILSILDEACASIGNVTDKVFLGELDKKLKSHKHYTSRNLKQS--DKSMGFEEFKITHYAGDV 516

  Fly   539 TYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPE--KELRSL-KRPETAITQFRASLNNLMD 600
            ||||.||:|||.|.||:|||..|..:.|.:|::.||:  |.:..: :||.||...|:.|::.|:.
Worm   517 TYSVMGFMDKNKDTLFQDLKRLLYHSKNRLVKSLFPDGSKSMAEVNRRPPTAGFLFKNSMSELVK 581

  Fly   601 ILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSL 665
            .|..|||.||||||||:.:.:|||:.|.|.|||:||||:||:||||||||:|..|:.|:.|||.:
Worm   582 QLAQKEPHYIRCIKPNEEKNSNVFDLERVEHQVRYLGLLENVRVRRAGFAHRMPYDRFVNRYKLI 646

  Fly   666 SKSTWPNYKGPGGPKAGVQ------QLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKH 724
            ..|||||      |:.|.|      |:::..|..::..: |.||:|||.|:|:|..|:...|:..
Worm   647 CASTWPN------PRRGQQLKDSCMQILESAGLAQDCVQ-GRTKIFIRSPQTVFRLEELRTEQLP 704

  Fly   725 EIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDA 789
            .:...:|...:|:.||.:|.::.|...|:.:|.|.||               :::|...|
Worm   705 NVITFLQKMVRGVQQRERYRRMLAVRKIIGAYRRYKL---------------KSYIWQLI----- 749

  Fly   790 PNGFNEEFIANAKRMWLLRLAKELPTKVLDKS--WPHAPGHCEEASGILHRLHRLHLARIYRLKL 852
             |.|.:     .:||           :.|.||  ||..|....:....|..:|:...|.....::
Worm   750 -NAFRD-----VRRM-----------RDLGKSIRWPAPPLVLAQFVSRLRVMHQRWRAATILARM 797

  Fly   853 TPQQKRQFELKVLAEKVFKGKKNNYA-------------------SSVSTWFQEDRIPKEHIQRV 898
            .|..:.....|:.|.:|...||.|:.                   ::|||:       .:.||.:
Worm   798 PPHLRASLPQKIAAFEVLNNKKENWGYTRMWRGDYLSQQEELELPTTVSTY-------HDGIQAL 855

  Fly   899 NDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYK-QKHRLPLDKID-FT 961
            ..  :..||  ::.:.::..||::.. ||..|.::::::.:..|:.|.:| .|..:||..|. .:
Worm   856 RQ--SHPFG--KVLFSTYVQKFNKFN-KSSLRVLIVTDRFVAKLENKKFKLLKEPIPLQSISRIS 915

  Fly   962 LTNHNDDLMVIRIPLDLKKDKGDLILI-IPRIIEFSTYIIDTVGT--ASIVSIVDRNS---LEHN 1020
            :...::.|.||.:        ||..:: ..:..:....:.:.:||  |....|..|.|   ::..
Worm   916 VCAESNGLFVIHV--------GDNDIVGCAKNTKNEERVGEMIGTLLAHYDKITMRRSPVLIQSA 972

  Fly  1021 VVKGKGG------VIDIQTGAEPGVVRDKGH 1045
            ||...||      |.|.:....|.|.:..|:
Worm   973 VVCTLGGKTRTIRVFDAENNNVPPVFKKNGN 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	345/704 (49%)
		MYSc_Myo1	52..707	CDD:276829	332/671 (49%)
		Myosin_TH1	863..1035	CDD:283635	42/204 (21%)
hum-5	NP_497809.1	MYSc	6..699	CDD:214580	345/703 (49%)
		MYSc_Myo1	26..687	CDD:276829	332/670 (50%)
		Myosin_TH1	808..986	CDD:283635	40/197 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720