Protein Alignment Myo61F and hum-5

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_497809.1
• Gene: hum-5 / 175521
• WormBaseID: WBGene00002038
• Length: 1017
• Species: Caenorhabditis elegans
• Alignment Length: 1071
• Identity: 420/1071 - (39%)
• Similarity: 612/1071 - (57%)
• Gaps: 120/1071 - (11%)

  Fly    27 METGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDH 91
            |..|.|:.:..||:|.|||..... ::.:.||:.|||:..||||||:||::||||:||.||....
 Worm     1 MSYGGHDPNGYGVEDLVLLSTIDL-KSVVQNLQLRFQKGRIYTYIGEVLVAVNPYRQLGIYEKST 64

  Fly    92 VKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG--N 154
            |..|:.:..||..||:||:.|.|:||:....|..|::||||||:||||.||.:::::||.:.  .
 Worm    65 VDQYKGREIYERAPHVFAIADAAYRSMKRFGRDSCIVISGESGAGKTETSKIIMKYLAAITNVRQ 129

  Fly   155 QTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVV 219
            |..:|.||:.||:||.:|||||.|||.||||||||||||.|.||:.|.|:||||.||||||||||
 Worm   130 QGEIERVKNVLLRSNCILEAFGCAKTTRNDNSSRFGKYMHINFDYDGDPVGGNISNYLLEKSRVV 194

  Fly   220 AQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQAL-T 283
            .|..||||||:||||:.|.|:.||::..|.:....|.:|..|.:..|..|||:..|.:||.|| :
 Worm   195 RQQEGERNFHVFYQLVNGGDDGLLRQFGLTKDAKQYYFLNQGQSHKVASINDSRDFAEVQTALRS 259

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGFTEVE---GNAKVNSRDLVVTAARLLGVNASELEAALTH 345
            :..|.|::...::.::|.::|||||.|.:.|   |...:..:..:..|||.|.|...||..:|:.
 Worm   260 IHTFDKQDVESMWSVIAGLIHLGNVRFIDGENSSGAVHIAEKAALQNAARCLNVTPDELAKSLSS 324

  Fly   346 RTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLN--ISLQAKETRASRNNVMGILD 408
            :.:.|.||:|....:...|.|.|||||||:|:|||||:|.::|  ||:| ..:|.|:::|:|:||
 Worm   325 QVVAAHGDIVKKQHDVNAAYYTRDALAKALYERLFSWMVSKVNEAISVQ-NSSRYSKSHVIGVLD 388

  Fly   409 IYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEK 473
            |||||||..|||||.|||:||||||||||||.||.||:||.||||:|:.:|||:|||||:|:|..
 Worm   389 IYGFEIFGTNSFEQLCINYCNEKLQQLFIELVLKQEQEEYEREGIKWVKIEYFNNKVICDLVEIP 453

  Fly   474 HKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEV 538
            ..||:|||||.|...|..|||.||.:|.:||..|.||.......:  .|.|..:||::.||||:|
 Worm   454 RTGILSILDEACASIGNVTDKVFLGELDKKLKSHKHYTSRNLKQS--DKSMGFEEFKITHYAGDV 516

  Fly   539 TYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPE--KELRSL-KRPETAITQFRASLNNLMD 600
            ||||.||:|||.|.||:|||..|..:.|.:|::.||:  |.:..: :||.||...|:.|::.|:.
 Worm   517 TYSVMGFMDKNKDTLFQDLKRLLYHSKNRLVKSLFPDGSKSMAEVNRRPPTAGFLFKNSMSELVK 581

  Fly   601 ILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSL 665
            .|..|||.||||||||:.:.:|||:.|.|.|||:||||:||:||||||||:|..|:.|:.|||.:
 Worm   582 QLAQKEPHYIRCIKPNEEKNSNVFDLERVEHQVRYLGLLENVRVRRAGFAHRMPYDRFVNRYKLI 646

  Fly   666 SKSTWPNYKGPGGPKAGVQ------QLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKH 724
            ..|||||      |:.|.|      |:::..|..::..: |.||:|||.|:|:|..|:...|:..
 Worm   647 CASTWPN------PRRGQQLKDSCMQILESAGLAQDCVQ-GRTKIFIRSPQTVFRLEELRTEQLP 704

  Fly   725 EIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDA 789
            .:...:|...:|:.||.:|.::.|...|:.:|.|.||               :::|...|
 Worm   705 NVITFLQKMVRGVQQRERYRRMLAVRKIIGAYRRYKL---------------KSYIWQLI----- 749

  Fly   790 PNGFNEEFIANAKRMWLLRLAKELPTKVLDKS--WPHAPGHCEEASGILHRLHRLHLARIYRLKL 852
             |.|.:     .:||           :.|.||  ||..|....:....|..:|:...|.....::
 Worm   750 -NAFRD-----VRRM-----------RDLGKSIRWPAPPLVLAQFVSRLRVMHQRWRAATILARM 797

  Fly   853 TPQQKRQFELKVLAEKVFKGKKNNYA-------------------SSVSTWFQEDRIPKEHIQRV 898
            .|..:.....|:.|.:|...||.|:.                   ::|||:       .:.||.:
 Worm   798 PPHLRASLPQKIAAFEVLNNKKENWGYTRMWRGDYLSQQEELELPTTVSTY-------HDGIQAL 855

  Fly   899 NDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYK-QKHRLPLDKID-FT 961
            ..  :..||  ::.:.::..||::.. ||..|.::::::.:..|:.|.:| .|..:||..|. .:
 Worm   856 RQ--SHPFG--KVLFSTYVQKFNKFN-KSSLRVLIVTDRFVAKLENKKFKLLKEPIPLQSISRIS 915

  Fly   962 LTNHNDDLMVIRIPLDLKKDKGDLILI-IPRIIEFSTYIIDTVGT--ASIVSIVDRNS---LEHN 1020
            :...::.|.||.:        ||..:: ..:..:....:.:.:||  |....|..|.|   ::..
 Worm   916 VCAESNGLFVIHV--------GDNDIVGCAKNTKNEERVGEMIGTLLAHYDKITMRRSPVLIQSA 972

  Fly  1021 VVKGKGG------VIDIQTGAEPGVVRDKGH 1045
            ||...||      |.|.:....|.|.:..|:
 Worm   973 VVCTLGGKTRTIRVFDAENNNVPPVFKKNGN 1003

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	332/671 (49%)
		Myosin_TH1	863..1049	CDD:461801	45/216 (21%)
hum-5	NP_497809.1	MYSc	6..699	CDD:214580	345/703 (49%)
		Myosin_TH1	808..986	CDD:461801	40/197 (20%)