DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and nmy-2

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_492186.3	Gene:	nmy-2 / 172562	WormBaseID:	WBGene00003777	Length:	2003	Species:	Caenorhabditis elegans

Alignment Length:	1056	Identity:	332/1056 - (31%)
Similarity:	510/1056 - (48%)	Gaps:	179/1056 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 METGLHERDRAG--------------VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLIS 77
            ||||  ||.|..              .:|..:| ...:|.:.:.|||:|:..:|.|||.|...:.
Worm    64 METG--ERQRVSSDDCQKPNPPKYDKCEDMSML-TCLNEASVLHNLKQRYFSNLYYTYSGLFCVV 125

  Fly    78 VNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASK 142
            :||||::|||||...:.::.|...|||||||||.|.|:||:::|...|.:|.:||||:||||.:|
Worm   126 INPYKRIPIYTDTIAEQFKCKKRKEMPPHIFAVADEAYRSMLQERDDQSILCTGESGAGKTENTK 190

  Fly   143 KVLQFIA------ACSGNQTTVE----------GVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGK 191
            ||:|::|      .....:|:|:          .::::||::||:||||||:||.:|||||||||
Worm   191 KVIQYLAYVANRSMVKNRKTSVDLDTSTNRIMGQLEEQLLQANPILEAFGNSKTVKNDNSSRFGK 255

  Fly   192 YMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYS 256
            ::.:.||..|...|.||..||||||||:.|...||:||||||||.|..:...:...||.:|..|.
Worm   256 FIRVHFDSTGCISGANIEFYLLEKSRVLKQAPNERSFHIFYQLLKGLSKVQREHYLLEDSLSKYK 320

  Fly   257 YLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGN--AKV 319
            ::::| :..:..::|....|:...|::::....||...|..:|::::..||:.|:....|  ..|
Worm   321 FVSNG-DSKLAGVDDGAEMKETLNAMSIMGLNDEEIGGILRVVSAVMLFGNLEFSHENKNNDQAV 384

  Fly   320 NSRDLVV-TAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWL 383
            ...|.|. ..|.|||||.:||..|.....|..:.|:|....:.:...::..|:|||.|:|||.||
Worm   385 LLNDAVAQKIASLLGVNVTELMRAFLKPKIKVQRDLVHRAQSVDQVNFSVGAIAKASYERLFRWL 449

  Fly   384 VQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEY 448
            |.|||.||.  .||....:.:|||||.|||||:.|||||.|||:.||||||||.......||.||
Worm   450 VHRLNKSLD--RTRQQSVSFIGILDIAGFEIFETNSFEQLCINYTNEKLQQLFNNTMFVREQQEY 512

  Fly   449 RREGIEWIPVEYFDN-KVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVC 512
            ..||:||..:::..| :...:|| :|..||:|.||:.||.| :..|::|:::|....:||..||
Worm   513 LDEGLEWKFLDFGLNLQPTIDLI-DKPMGIMSTLDDVCLFP-QGNDQSFVQRLNNTHSQHPKYV- 574

  Fly   513 HEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLL-------FRDLKETL--------- 561
                   :.:|..|.:|.:|||||.|.|...|:..||.|.|       .:..||:|
Worm   575 -------VPEIRSRSDFAVVHYAGRVDYQSEGWRVKNMDPLNENVIDVLKTSKESLIVDMWKDIA 632

  Fly   562 ---------SKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIKPND 617
                     |.:..|:..:..|:|.:.     .|....::..|..||..|....|.::|||.||.
Worm   633 DVCSLSAADSTSDTGVFGSRVPKKGMF-----RTVSQLYKEQLARLMSTLNNTNPHFVRCIIPNH 692

  Fly   618 LQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGG---P 679
            .:...|.|..|||.|::..|::|.:|:.|.||..|..::.|.:||:.|..   |:. .|.|   .
Worm   693 EKKHGVLNAHLVLDQLRCNGVLEGIRICRQGFPTRLPFQEFRQRYEKLLA---PDV-NPAGFMDG 753

  Fly   680 KAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYL 744
            |..|.::|:.|..|...:|:|::|:|.| ...:.:.|:...:|...:....||..:|.:.||..:
Worm   754 KNAVYRIVQYLEVDANLFRIGQSKIFFR-SGVIAEFEEMRDQKLSALIESFQAQCRGWLGRRVMV 817

  Fly   745 KLRAQVIIMQSYCRRKLA--------------------------QQAAKKRRE---AADKIR--- 777
            :.|.|.:.::...|..||                          :..|::.:|   .|:|:|
Worm   818 RRREQEVAIKILQRNGLAWMRLREWQWWRLLTKVKPLLEVTNKDELIAEREQELKVTAEKLRRSE 882

  Fly   778 AFIKGF--------------ITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGH 828
            .||..:              .||.||.:....|......||...|
Worm   883 VFISDYKQQMEKMDEERLVLKTRLDAESSERAEIFEERSRMAARR-------------------- 927

  Fly   829 CEEASGILHRLHRLHLARIYRLKLTPQ--QKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIP 891
             :|..|||..:.:       ||::..|  :|...|.:.|.|.|...::|......|.  |:..:.
Worm   928 -DELEGILEEVSK-------RLEIEEQKAKKADSESRKLTEMVRHLEENLEDEERSR--QKLLLE 982

  Fly   892 KEHIQ-RVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLD--GKTYKQKHRL 953
            |..|: |:.:..|     :.|:.:....|..:......:|...||::.|..::  .:..|.|.||
Worm   983 KNSIESRLKELEA-----QGLELEDSGNKLSKEKKALEERCEDLSSRLIDEVERSKQLVKAKARL 1042

  Fly   954 PLDKIDFTLTNHNDDL 969
                 :.|:...||:|
Worm  1043 -----EATVAEINDEL 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	269/749 (36%)
		MYSc_Myo1	52..707	CDD:276829	261/702 (37%)
		Myosin_TH1	863..1035	CDD:283635	24/110 (22%)
nmy-2	NP_492186.3	MYSc	81..793	CDD:214580	266/735 (36%)
		MYSc_class_II	100..781	CDD:276951	261/702 (37%)
		Myosin_tail_1	858..1934	CDD:279860	48/236 (20%)
		ATP-synt_B	<1104..1195	CDD:304375
		CDC37_N	<1317..1396	CDD:296150
		Orbi_VP5	1599..>1865	CDD:279272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920