Protein Alignment Myo61F and myo-1

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_492053.1
• Gene: myo-1 / 172471
• WormBaseID: WBGene00002348
• Length: 1938
• Species: Caenorhabditis elegans
• Alignment Length: 1131
• Identity: 329/1131 - (29%)
• Similarity: 523/1131 - (46%)
• Gaps: 222/1131 - (19%)

  Fly    48 YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTD 112
            :.::.:.:.||:.|:...|||||.|...:.:||||:||||||...:.:..|...|||||:|||:|
 Worm    94 FLNDASVLWNLRSRYAAMLIYTYSGLFCVVINPYKRLPIYTDSVARMFMGKRRTEMPPHLFAVSD 158

  Fly   113 NAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTV--EGVK-----DKLLKSNP 170
            .|:|.:::::..|.:||:||||:||||.:|||:.:.|....:|...  ||.|     |:::::||
 Worm   159 QAYRYMLQDHENQSMLITGESGAGKTENTKKVICYFATVGASQKAALKEGEKEVTLEDQIVQTNP 223

  Fly   171 VLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLL 235
            ||||||||||.||:|||||||::.|.|:..|.....:|.:||||||||:.|..|||.:|||||:.
 Worm   224 VLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTLASCDIEHYLLEKSRVIRQAPGERCYHIFYQIY 288

  Fly   236 AGADEALLQELRLERALDTYSY------LTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQRE 294
            :.....|..||.|...:..|.:      |.||       |:|.:.|:...:|..|:.|:..|:.:
 Worm   289 SDFKPQLRDELLLNHPISNYWFVAQAELLIDG-------IDDTEEFQLTDEAFDVLKFSPTEKMD 346

  Fly   295 IFGIVASILHLGNVGFTE--VEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDVVTS 357
            .:.::::.:|:||:.|.:  .|..|:.:.:|....|..:.|::..:...||....:....:.|:.
 Worm   347 CYRLMSAHMHMGNMKFKQRPREEQAEPDGQDEAERACNMYGIDVDQFLKALVSPRVKVGTEWVSK 411

  Fly   358 PLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQ 422
            ..|.:...:|..|:||.:|.|:|.|||::.|::|..|  ...|:..:|:|||.|||||..|||||
 Worm   412 GQNVDQVHWAIGAMAKGLYARVFHWLVKKCNLTLDQK--GIDRDYFIGVLDIAGFEIFDFNSFEQ 474

  Fly   423 FCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLR 487
            ..|||.||||||.|.......||:||.||||:|..:::..:...|..:.||..||||:|||||:.
 Worm   475 LWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIEKPLGIISMLDEECIV 539

  Fly   488 PGEPTDKTFLEKLT-QKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKN-- 549
            | :.||.|..:||| |.|.:|.::   || |...|.......|.:.||||.|.|:|..:|:||
 Worm   540 P-KATDMTLAQKLTDQHLGKHPNF---EK-PKPPKGKQGEAHFAMRHYAGTVRYNVLNWLEKNKD 599

  Fly   550 ---------------NDLLF--------RDLKETLSKAGNGIVRNCFPEKELRSLKRPETAIT-- 589
                           ||||.        ::.....:|||.|           |...:..:.:|
 Worm   600 PLNDTVVSVMKASKKNDLLVEIWQDYTTQEEAAAAAKAGGG-----------RKGGKSGSFMTVS 653

  Fly   590 -QFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRR 653
             .:|.|||.||.:|....|.:||||.||:.:.:.:.:..|||:|:...|::|.:|:.|.||..|.
 Worm   654 MMYRESLNKLMTMLHKTHPHFIRCIIPNEKKQSGMIDAALVLNQLTCNGVLEGIRICRKGFPNRT 718

  Fly   654 TYELFLERYKSL----SKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFD 714
            .:..|::||..|    :||: .:.|...|  |.:|.|:.....::|::|:|.||:|.: ...:..
 Worm   719 QHPDFVQRYAILAAKEAKSS-DDMKTCAG--AILQALINQKQLNDEQFRIGHTKVFFK-AGVVAH 779

  Fly   715 TEDAYQEKKHEIAAIIQA--HW----KGLMQRRKYLKLRAQVII---MQSYC------------- 757
            .||...:|.::|....|:  .|    .....|||  :|.:.:|:   ::|:|
 Worm   780 IEDLRDDKLNQIITGFQSAIRWYTATADAGARRK--QLNSYIILQRNIRSWCVLRTWDWFLLFGK 842

  Fly   758 --------------------------RRKLAQQAAKKRREAADKI-----------------RAF 779
                                      ..|.|:.|.|.:.||..|:                 .|.
 Worm   843 LRPQLKCGKMAEEMIKMAEEQKVLEAEAKKAESARKSQEEAYAKLSAERSKLLEALELTQGGSAA 907

  Fly   780 IKGFITR------------NDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGH---- 828
            |:..:||            |||.:..:|....||......|.|:: ..:.|.||.....|:
 Worm   908 IEEKLTRLNSARQEVEKSLNDANDRLSEHEEKNADLEKQRRKAQQ-EVENLKKSIEAVDGNLAKS 971

  Fly   829 CEEASGILHRLHRLH---------LARIYR-LKLTPQQKRQFELKVLAEKVFKGKKNNYASSVST 883
            .||.:...:::|.|.         :.:|.: .||..:..||....:.||:..:.:.|.....:..
 Worm   972 LEEKAAKENQIHSLQDEMNSQDETIGKINKEKKLLEENNRQLVDDLQAEEAKQAQANRLRGKLEQ 1036

  Fly   884 WFQEDRIPKEHIQRVNDFVASTFGSE-----QLK------------------------------- 912
            ...|   .:|.::|.....|.|..|:     :||
 Worm  1037 TLDE---MEEAVEREKRIRAETEKSKRKVEGELKGAQETIDELSAIKLETDASLKKKEADIHALG 1098

  Fly   913 -----YQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRL----PLDKIDFTLTNHNDD 968
                 .|:...:..|...::..|.|.:.::..:....::...:.|.    .||:::..|...|..
 Worm  1099 VRIEDEQALANRLTRQSKENAQRIIEIEDELEHERQSRSKADRARAELQRELDELNERLDEQNKQ 1163

  Fly   969 LMVIRIPLDLKKDKGDLILIIPRIIE 994
            |   .|..|..|.|...|:...|.::
 Worm  1164 L---EIQQDNNKKKDSEIIKFRRDLD 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	257/702 (37%)
		Myosin_TH1	863..1049	CDD:461801	27/177 (15%)
myo-1	NP_492053.1	Myosin_N	30..73	CDD:460670
		MYSc_class_II	98..773	CDD:276951	257/702 (37%)
		Myosin_tail_1	854..1919	CDD:460256	59/340 (17%)