Protein Alignment Myo61F and Myh7

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_001348536.1
• Gene: Myh7 / 140781
• MGIID: 2155600
• Length: 1935
• Species: Mus musculus
• Alignment Length: 1089
• Identity: 330/1089 - (30%)
• Similarity: 532/1089 - (48%)
• Gaps: 197/1089 - (18%)

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:| .:..|.|.:.|||:|:...:||||.|...::|||||.||:|..:.|.|||.|...|.
Mouse    87 IEDMAML-TFLHEPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEA 150

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG-------NQTTVEG- 160
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|..:.       :||..:|
Mouse   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGT 215

  Fly   161 VKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGE 225
            ::|:::::||.|||||||||.||||||||||::.|.|...|.....:|..||||||||:.|:..|
Mouse   216 LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAE 280

  Fly   226 RNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKE 290
            |::|||||:|:.....||..|.:......|::::.| ..||..|:|::.......|..|:.||.|
Mouse   281 RDYHIFYQILSNKKPELLDMLLITNNPYDYAFISQG-ETTVASIDDSEELMATDSAFDVLGFTPE 344

  Fly   291 EQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGD 353
            |:..|:.:..:|:|.||:.|.:.  |..|:.:..:....:|.|:|:|:::|...|.|..:....:
Mouse   345 EKNSIYKLTGAIMHFGNMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLKGLCHPRVKVGNE 409

  Fly   354 VVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKN 418
            .||...|.:...||..||||:||:::|:|:|.|:|.:|   ||:..|...:|:|||.|||||..|
Mouse   410 YVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRINATL---ETKQPRQYFIGVLDIAGFEIFDFN 471

  Fly   419 SFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDE 483
            ||||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||:|||:|
Mouse   472 SFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGIMSILEE 536

  Fly   484 ECLRPGEPTDKTFLEKL-TQKLAQHHHYVCHEKAPAHIKKIMLRDE--FRLVHYAGEVTYSVNGF 545
            ||:.| :.||.||..|| ...|.:.:::    :.|.::|.   :.|  |.||||||.|.|::.|:
Mouse   537 ECMFP-KATDMTFKAKLYDNHLGKSNNF----QKPRNVKG---KQEAHFSLVHYAGTVDYNILGW 593

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCF---------PEKELRSLKRP---ETAITQFRASLNNL 598
            |.||.|.|...:.....|:...::.|.|         .:|.....|:.   :|.....|.:||.|
Mouse   594 LQKNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPADKGKGKAKKGSSFQTVSALHRENLNKL 658

  Fly   599 MDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYK 663
            |..|....|.::|||.||:.::..|.::.||:||::..|::|.:|:.|.||..|..|..|.:||:
Mouse   659 MTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYR 723

  Fly   664 SLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAA 728
            .|:.:..|..:.....| |.::|:..|..|..:|:.|.||:|.: ...|...|:...|:...|..
Mouse   724 ILNPAAIPEGQFIDSRK-GAEKLLGSLDIDHNQYKFGHTKVFFK-AGLLGLLEEMRDERLSRIIT 786

  Fly   729 IIQAHWKGLMQRRKYLKL---RAQVII----------------MQSYCRRKLAQQAAKKRREAAD 774
            .|||..:|::.|.::.||   |..::|                |:.|.:.|...::|:..:|.|.
Mouse   787 RIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMAT 851

  Fly   775 KIRAF--IKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILH 837
            ....|  :|..:.:::|..                   |||..|::               .:|
Mouse   852 MKEEFGRVKDALEKSEARR-------------------KELEEKMV---------------SLL- 881

  Fly   838 RLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASS-------VSTWFQEDRIPKEHI 895
                             |:|...:|:|.||      ::|.|.:       :....|.:...||..
Mouse   882 -----------------QEKNDLQLQVQAE------QDNLADAEERCDQLIKNKIQLEAKVKEMT 923

  Fly   896 QRVND--FVASTFGSEQLKYQSFCTKF----------------DRHGYKSR-----------DRF 931
            :|:.|  .:.:...:::.|.:..|::.                ::|..:::           |..
Mouse   924 ERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEI 988

  Fly   932 ILLSNKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHN-------DDL-------MVIRIPL 976
            |:...|     :.|..::.|:..||.:..      |||...       |||       ..:|:.|
Mouse   989 IVKLTK-----EKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDL 1048

  Fly   977 DLKKDK--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023
            :..|.|  |||.|....|::...               |:..|:..:.|
Mouse  1049 ERAKRKLEGDLKLTQESIMDLEN---------------DKQQLDERLKK 1082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	264/705 (37%)
		MYSc_Myo1	52..707	CDD:276829	259/679 (38%)
		Myosin_TH1	863..1035	CDD:283635	38/219 (17%)
Myh7	NP_001348536.1	COG5022	37..1432	CDD:227355	330/1089 (30%)
		MYSc_class_II	99..766	CDD:276951	259/679 (38%)
		Actin-binding	655..677		10/21 (48%)
		Actin-binding	757..771		4/14 (29%)
		SMC_prok_B	1173..1930	CDD:274008
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1915..1935

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000