DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and Myo1b

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_038938876.1	Gene:	Myo1b / 117057	RGDID:	70994	Length:	1149	Species:	Rattus norvegicus

Alignment Length:	1102	Identity:	467/1102 - (42%)
Similarity:	655/1102 - (59%)	Gaps:	161/1102 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            ||.|.||||.. :||.||.||||||..:.||||||.|:||||||:.||||:.:.|:.|||::|||
  Rat    16 GVGDTVLLEPL-NEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLPIYSPEKVEDYRNRNFYE 79

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGVKDKLLK 167
            :.|||||::|.|:|||.::::.||:||:||||:|||||||.|:.::||..|....|..||::||:
  Rat    80 LSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVCGKGAEVNQVKEQLLQ 144

  Fly   168 SNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFY 232
            |.|||||||||||.||||||||||||||:|||||.|:||.|.||||||||||.|..||||||:||
  Rat   145 STPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHVFY 209

  Fly   233 QLLAGADEALLQ-----------ELRLERALDTYSYLT-DGLNGTVTRINDADSFKQVQQALTVI 285
            |||:||.|.||:           :|:|||....|:||: |  :..|..::||.:|:.|:.|:.::
  Rat   210 QLLSGASEELLRKSMGASEELLHKLKLERDFSRYNYLSLD--SAKVNGVDDAANFRTVRNAMQIV 272

  Fly   286 DFTKEEQREIFGIVASILHLGNVGF---TEVEG--NAKVNSRDLVVTAARLLGVNASELEAALTH 345
            .|:..|...:..:||::|.|||:.|   :.:.|  .:|:..::.:.....|..::...||.|.:.
  Rat   273 GFSDPEAESVLEVVAAVLKLGNIEFKPESRMNGLDESKIKDKNELKEICELTSIDQVVLERAFSF 337

  Fly   346 RTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIY 410
            ||::|:.:.|::.||...|.||||||||.:|.|||||||.|:|.|::| :|:. |..|||:||||
  Rat   338 RTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESIKA-QTKV-RKKVMGVLDIY 400

  Fly   411 GFEIFQK--NSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEK 473
            |||||:.  ||||||.||:|||||||:|||||||.||:||.||.|||..::||:|.:||:|||..
  Rat   401 GFEIFENADNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHIDYFNNAIICDLIENN 465

  Fly   474 HKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCH-EKAPAHIKKIMLRDE-FRLVHYAG 536
            ..||:::|||||||||..||:||||||.|..|.|.|:... .|....:....|... ||:.||||
  Rat   466 TNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDTTLPHSCFRIQHYAG 530

  Fly   537 EVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELR--SLKRPETAITQFRASLNNLM 599
            :|.|.|.||:|||||||:|||.:.:.|||:.::::.|||....  :||||.||.:||:||:..||
  Rat   531 KVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSLFPEGNPAKVNLKRPPTAGSQFKASVATLM 595

  Fly   600 DILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKS 664
            ..|..|.|:|||||||||.:.|::|::.||.||::||||:||:||||||:|:|:.||..|||||.
  Rat   596 KNLQTKNPNYIRCIKPNDKKAAHIFSESLVCHQIRYLGLLENVRVRRAGYAFRQAYEPCLERYKM 660

  Fly   665 LSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAI 729
            |.|.|||::|||.  ::||:.|..:|....|:|..|.:|:|||.|||||..||..:::..::|.:
  Rat   661 LCKQTWPHWKGPA--RSGVEVLFNELEIPVEEYSFGRSKIFIRNPRTLFQLEDLRKQRLEDLATL 723

  Fly   730 IQAHWKG--------LM---------------QRRKYLKLRAQVIIMQSYCR----RKLAQ---- 763
            ||..::|        ||               |:::|.::::..:::|||.|    ||:.:
  Rat   724 IQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQQKRYQQIKSSALVIQSYIRGWKARKILRELKH 788

  Fly   764 ------------------QAAKKRREAADKIR---------AFIKGFITRNDAPNGFNEE----- 796
                              ||.|:||...|:.|         ||..|...|.:... ..||
  Rat   789 QKRCKEAATTIAAYWHGTQARKERRRLKDEARNKHAIAVIWAFWLGSKARRELKR-LKEEARRKH 852

  Fly   797 ---------------------FIANAKR------------MWLLRLAKELPT-KVLDKSWPHAP- 826
                                 |.|||.:            .:||.:..::|: ..:||:||..|
  Rat   853 AVAVIWAYWLGLKVRREYRKFFRANAGKKIYEFTLQRIVQKYLLEMKNKMPSLSPIDKNWPSRPY 917

  Fly   827 -----GHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQ 886
                 .|.|     |.|:..|...:.||.:.|.|||..:|.|:.|.::||.||..|.|||...||
  Rat   918 LFLDSTHKE-----LKRIFHLWRCKKYRDQFTDQQKLIYEEKLEASELFKDKKALYPSSVGQPFQ 977

  Fly   887 E-----DRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKT 946
            .     ::.||  .:::.|.:     .|::.......|.:|...||..|..||:|..:.:.|.|:
  Rat   978 GAYLEINKNPK--YKKLKDAI-----EEKIIIAEVVNKINRANGKSTSRIFLLTNNNLLLADQKS 1035

  Fly   947 YKQKHRLPL-DKIDFTLTNHNDDLMVIRIPLDLKK-----DKGDLILIIPRIIEFSTYIIDT 1002
            .:.|..:|| |....::::.||....:.    ||:     .|||.:.....:||.:|.:..|
  Rat  1036 GQIKSEVPLVDVTKVSMSSQNDGFFAVH----LKEGSEAASKGDFLFSSDHLIEMATKLYRT 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	375/704 (53%)
		MYSc_Myo1	52..707	CDD:276829	358/677 (53%)
		Myosin_TH1	863..1035	CDD:283635	41/151 (27%)
Myo1b	XP_038938876.1	MYSc_Myo1	29..701	CDD:276829	358/677 (53%)
		IQ	762..784	CDD:197470	6/21 (29%)
		Myosin_TH1	954..1131	CDD:399188	41/151 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820