DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and LOC101733172

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_031759908.1	Gene:	LOC101733172 / 101733172	-ID:	-	Length:	1008	Species:	Xenopus tropicalis

Alignment Length:	1050	Identity:	422/1050 - (40%)
Similarity:	595/1050 - (56%)	Gaps:	93/1050 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYR 96
            ||....|..|||||:.. :.:||:.|:|.||:...||||||:|::|||||:.:.:|..:.:..||
Frog     4 HEGLEFGKADFVLLDQV-TMDAFMANMKLRFERGRIYTYIGEVVVSVNPYRSMELYGKEMIDFYR 67

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG--NQTTVE 159
            .:..||.|||::|:.|.|::::....:..|::||||||||||||||.::|:|||.:.  .:..||
Frog    68 GRELYERPPHLYAIADAAYKAMKRRAKDTCIVISGESGSGKTEASKYIMQYIAAITNPTQRQEVE 132

  Fly   160 GVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGG 224
            .||:.|||||.:||||||||||||||||||||||||.|||||.|.||:|.|||||||||:.|..|
Frog   133 RVKNILLKSNCLLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPTGGHISNYLLEKSRVLKQQPG 197

  Fly   225 ERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTK 289
            |||||.|||||.||.|..|....|:|....|::..||:......|:|..|:|.|..::.||.|..
Frog   198 ERNFHSFYQLLCGASEEQLNSFHLQRDPAFYTFTRDGVTLNNFPISDKSSYKAVLDSMKVIGFRP 262

  Fly   290 EEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTI-DARGD 353
            ||...::.|:|:||||||:||.....:..:|:.:||...|:|....|..:...|.:|.: ...||
Frog   263 EEMDSVYRILAAILHLGNLGFDTDGDSVIINNEELVPHIAQLTHCPAHCVMKTLLYRMVATGGGD 327

  Fly   354 VVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRA---SRNNVMGILDIYGFEIF 415
            |:....|.:.|.|||||.|||.|:|||.|:|.|:|..::.|...|   .:|.|:|:|||||||||
Frog   328 VIEKGHNLKEASYARDACAKAFYERLFCWIVGRINSVIEVKNYDARIHGKNTVIGVLDIYGFEIF 392

  Fly   416 QKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISI 480
            ..|||||||||:||||||||||||.|:.|||||:||||||..::||:|::|.:|:|:.|||||||
Frog   393 DNNSFEQFCINYCNEKLQQLFIELILRQEQDEYQREGIEWQHIDYFNNQIIVDLVEQPHKGIISI 457

  Fly   481 LDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGF 545
            |||.||..||.||..|||.:..||.:|.||...:.:|.. |.:....:||:.||||.|||||.||
Frog   458 LDEACLTVGEVTDTIFLESMNTKLCKHPHYTSRKLSPTD-KSMAFNRDFRIKHYAGFVTYSVEGF 521

  Fly   546 LDKNNDLLFRDLKETLSKAGNGIVRNCFPEKEL---RSLKRPETAITQFRASLNNLMDILMCKEP 607
            ||||.|.||:|.|..:..:.:.::|:.:|:.:|   ...|||.||.|.|:.|:.:|:|.|.||||
Frog   522 LDKNKDTLFQDFKRLMYNSKDPVLRDMWPDGQLSISEVTKRPLTAATLFKNSMISLVDNLACKEP 586

  Fly   608 SYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPN 672
            .|:|||||||.:..::|:::...|||:||||:||:||||||||||:.||.||.|||...:.||||
Frog   587 YYVRCIKPNDQKAPHLFDEQRCRHQVEYLGLLENVRVRRAGFAYRQPYERFLLRYKMTCEYTWPN 651

  Fly   673 YKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGL 737
            :......:|.  :.:.|....|:....|.||:|||.|:|||..|:...|....|...:|..|:|.
Frog   652 HLMDSDMEAA--KALIDHHRFEDDVAYGRTKVFIRTPQTLFSLEEERAELMPLIILFLQKLWRGT 714

  Fly   738 MQRRKYLKLRAQVIIMQSY-CRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIANA 801
            :.|.::.||||...||:.| |.                |:|:.:...:.|
Frog   715 VARMRFKKLRAVYAIMRHYKCY----------------KVRSHLLEVVNR--------------- 748

  Fly   802 KRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLA 866
                 .:..:.:|.......||..|...|:...|...|.:...||.....:.|....|.:.||.|
Frog   749 -----FQQVRNMPDFGKSVEWPEPPTVLEKFQEISRNLFKRWRARQIVRNIPPSDMAQIKAKVAA 808

  Fly   867 EKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGS--EQLK---------YQSFCTKF 920
            .:..:..:  |.......::.|.:..|   :.|...||.|..  ::||         :.....|.
Frog   809 MEALQDLR--YDIGYERAWRHDYLSCE---KDNPLAASQFSKILQELKKKESRLSVLFSCHIRKI 868

  Fly   921 DRHGYKSRDRFILLSNKAIYVLD-GKTYKQKHRLPLDKI-DFTLTNHNDDLMVIR------IPLD 977
            :|.. |.:||.:|::...:|.:: .|.||....:||..: ..::|...|.|.|:.      :...
Frog   869 NRFS-KCKDRALLITEHHLYKMEPKKQYKVIKVIPLSTVTGLSITGGRDQLAVLHTRKHEDMAFC 932

  Fly   978 LKKDK-------GDLILIIPRII-----EFSTYIIDTV-----GTASIVSIVDRNSL-EHNVVKG 1024
            |.|.:       |:|:..:....     |.|..:.|.:     |...:||:..|||: :.:..||
Frog   933 LHKMEPANESRLGELVGTLANHFNSQRWELSVKVTDCIQMNVHGRRRLVSVETRNSIAQPDFCKG 997

  Fly  1025 KGGVIDIQTG 1034
            :.|::.:..|
Frog   998 RNGLVLLWPG 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	349/696 (50%)
		MYSc_Myo1	52..707	CDD:276829	334/663 (50%)
		Myosin_TH1	863..1035	CDD:283635	44/208 (21%)
LOC101733172	XP_031759908.1	MYSc_Myo1	23..684	CDD:276829	334/663 (50%)
LOC101733172	XP_031759908.1	Myosin_TH1	805..999	CDD:399188	43/199 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000