DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and myo1d

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_002935562.1	Gene:	myo1d / 100497691	XenbaseID:	XB-GENE-5877220	Length:	1007	Species:	Xenopus tropicalis

Alignment Length:	976	Identity:	406/976 - (41%)
Similarity:	584/976 - (59%)	Gaps:	78/976 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 GVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYE 102
            |..||||:::....| |:.|||.||::..|||:||:|::||||||.||||..|.::.|:.:..||
Frog    10 GKADFVLMDSVTLPE-FMENLKLRFEKGRIYTFIGEVVVSVNPYKNLPIYGRDTIEQYKGRELYE 73

  Fly   103 MPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACS--GNQTTVEGVKDKL 165
            .|||:|::.|.|::::....:..|::||||||:|||||||.::|:|||.:  ..:..||.||:.|
Frog    74 RPPHLFSIADAAYKAMKRRCKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNML 138

  Fly   166 LKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHI 230
            ||||.|||||||||||||||||||||||||.|||||.||||:|.|||||||||:.|..||||||.
Frog   139 LKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHISNYLLEKSRVIVQQLGERNFHS 203

  Fly   231 FYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREI 295
            |||::.||.|..|:.|.|::.:..|:| |..|....:..||...||.|.:|:.||.|..||.:.:
Frog   204 FYQMILGAPEQTLRSLHLQKDISLYAY-TRSLAQLKSSNNDTGDFKDVAEAMKVIGFKPEEIQTV 267

  Fly   296 FGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDARGDVVTSPLN 360
            :.|:|:||||||:.|........:.:..::...|.|||..:.::|.||..||:....||:.....
Frog   268 YKILAAILHLGNLKFVLDGDTTLIENGKVISVVADLLGTRSEQVEKALLFRTVATGRDVIDKQHT 332

  Fly   361 QELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRAS---RNNVMGILDIYGFEIFQKNSFEQ 422
            ::.|.|.|||.|||:|:|||.|:|.|:|..:..|:..|:   :|.|:|:|||||||||..|||||
Frog   333 EKEANYGRDAFAKAIYERLFCWIVNRINDVIDVKQQDAALHGKNTVIGVLDIYGFEIFDNNSFEQ 397

  Fly   423 FCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLR 487
            ||||:||||||||||:|.|..||.||:||||.|..::||||::|.:|:|::|:|||::||:.|:.
Frog   398 FCINYCNEKLQQLFIQLVLTQEQAEYQREGIPWKHIDYFDNQIIVDLVEQQHRGIIALLDDACMN 462

  Fly   488 PGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDL 552
            .|:.||..|||.|.::|.:|.|| ...|..|..|.:....:||:.||||:|.|||.||:|||.|.
Frog   463 VGKVTDNMFLEALDKQLGKHAHY-SSRKVCATDKALEYNRDFRIRHYAGDVVYSVVGFIDKNKDT 526

  Fly   553 LFRDLKETLSKAGNGIVRNCFPEKEL---RSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIK 614
            ||:|.|..:..:.|.:::..:||.:|   ...|||.||.|.|:.|:..|:|.|..|||.|:||||
Frog   527 LFQDFKRLMFNSSNAVLKAMWPEGKLSITEVTKRPLTAATLFKNSMIALVDNLASKEPYYVRCIK 591

  Fly   615 PNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGP 679
            ||:.::..:|::....|||:||||:||:||||||||||:.||.||.|||.:|..||||:..| ..
Frog   592 PNEKKSPALFDEVRCKHQVEYLGLLENVRVRRAGFAYRQVYEKFLHRYKLISSLTWPNHSLP-SD 655

  Fly   680 KAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYL 744
            :..|::.:.|.|.:.:. ..|:||:|||.|||||..|:...|....|...:|..|:|.:.||:..
Frog   656 RIAVERFMVDCGLNHDA-AYGKTKIFIRTPRTLFFLEERRSEMLIRIILFLQKLWRGTLARRRCK 719

  Fly   745 KLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITR-NDAPNGFNEEFIANAKRMWLLR 808
            ::||.:.|::.|.|.               |::::::..:.| |...|  :.::..:.|  |
Frog   720 RIRAGLTILRYYRRY---------------KVKSYLREVMHRFNGVKN--SRDYGKHVK--W--- 762

  Fly   809 LAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGK 873
               ..|.|||.:        .:||  :.|..:|....:|.| .|.|.:..:...||.|.:..||.
Frog   763 ---PTPPKVLRR--------FQEA--LQHIYNRWRGYQIIR-SLPPAEIPKVRAKVAAFENLKGH 813

  Fly   874 KNN------YASSVSTWFQEDRIPKE-------HIQRVNDFVASTFGSEQLKYQSFCTKFDRHGY 925
            :.:      :..|.....||:....:       .:||.:.|:.:.|.....|...|        .
Frog   814 RVDMGLQRCWEGSYLALNQENGRDSDLFVSRSSELQRKDKFMQALFSCHVRKVNRF--------N 870

  Fly   926 KSRDRFILLSNKAIYVLD-GKTYKQKHRLPLDKID-FTLTNHNDDLMVIRIPLDLKKDKGDLILI 988
            |..||.|.::::.:|.:| ||.||.....||..:. .::|:..|.|:|..     .||..|||:.
Frog   871 KVEDRAIFITDRHLYKMDPGKAYKVMTSTPLYNVSGISVTSGKDQLVVFH-----TKDNKDLIVC 930

  Fly   989 I 989
            :
Frog   931 L 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	341/689 (49%)
		MYSc_Myo1	52..707	CDD:276829	328/662 (50%)
		Myosin_TH1	863..1035	CDD:283635	35/142 (25%)
myo1d	XP_002935562.1	MYSc_Myo1	24..682	CDD:276829	328/662 (50%)
myo1d	XP_002935562.1	Myosin_TH1	803..1004	CDD:368706	35/142 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010