DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and myo1f

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_002938604.1	Gene:	myo1f / 100493342	XenbaseID:	XB-GENE-5909751	Length:	1095	Species:	Xenopus tropicalis

Alignment Length:	906	Identity:	371/906 - (40%)
Similarity:	527/906 - (58%)	Gaps:	105/906 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MDTKDYIDFNSQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLIS 77
            |.:|:...:.||        ...::||.|.|||... :|:|.:.|||||:.:|.|:||||.||||
Frog     1 MGSKERYHWQSQ--------NVKQSGVDDMVLLSKI-TEDAIVENLKKRYLDDYIFTYIGSVLIS 56

  Fly    78 VNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASK 142
            |||:||:|.:|:..::.|:....||.||||:|:|||.:|:::.:...|||:||||||:|||.|:|
Frog    57 VNPFKQMPYFTEREIELYQGAAQYENPPHIYALTDNMYRNMLIDGENQCVIISGESGAGKTVAAK 121

  Fly   143 KVLQFIAACSGNQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGN 207
            .::.:|:..||..:.|:.|||.:|:|||:|||||||||.||:||||||||.:|||...|.|.||.
Frog   122 YIMGYISKVSGGGSKVQHVKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGK 186

  Fly   208 ILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDA 272
            |.|:||||||||:|...|||||:||||:.||.:...|.|.: ...|.:.||.......|...||.
Frog   187 ISNFLLEKSRVVSQNENERNFHVFYQLIEGASDEQRQNLGI-MTPDYFFYLNQSETYKVEGTNDK 250

  Fly   273 DSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNAS 337
            ..|.::.:|:.||..:.|||:.:..|.|.||||||:.|.|....|||...||:...|.||||...
Frog   251 KDFYEMLEAMMVIGVSAEEQQMVLQISAGILHLGNISFQEQGNYAKVECPDLLDFPAYLLGVQKG 315

  Fly   338 ELEAALTHRTIDA----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRA 398
            .|...||.|.:|:    |.:.:|..||.|.|.|.||||:||:|.|:|.:||:.:|.::|......
Frog   316 RLNDKLTSRKMDSKWGGRSESITVTLNVEQASYTRDALSKALYARVFDFLVESINKAMQKPYEEY 380

  Fly   399 SRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDN 463
            |    :|:||||||||||||.||||||||.||||||:|||||||:||:||..|||.|.|:|||:|
Frog   381 S----IGVLDIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVAEGIRWTPIEYFNN 441

  Fly   464 KVICNLIEEK--HKGIISILDEECL---RPGEPTDKTFLEKLTQKLAQHHH-------YVCHEKA 516
            |::|:|||.|  ..||:|:||:.|.   ..|...|:|.|:||...:..|.|       :|.|
Frog   442 KIVCDLIENKLNPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFSNWNLGFVIH--- 503

  Fly   517 PAHIKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSL 581
                            ||||:|:|.|.||.::|.|:||.||.|.:..:....:::.|||: |.|.
Frog   504 ----------------HYAGKVSYYVEGFCERNRDVLFIDLIELMQSSEYQFIQSLFPER-LDSD 551

  Fly   582 K--RPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRV 644
            |  ||.||.::.:...|:|::.||...|.||||||||:.:....:.:..|.|||:||||.||:||
Frog   552 KKSRPTTAGSKIKKQANDLVNTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRV 616

  Fly   645 RRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWP 709
            |||||||||.:..||:||..|::.|||.::  |..:.|||.|::.:..|.::|::|::|:|::.|
Frog   617 RRAGFAYRRVFNKFLQRYAILTQETWPRWR--GDERQGVQHLLRSVNMDSDQYQMGKSKVFVKNP 679

  Fly   710 RTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVI-IMQSYCRRK------------- 760
            .:||..|:..:.|....|..||..|:..:.||||.::|.:.. |:..|..|:
Frog   680 ESLFLLEEMRERKFDTFARTIQKAWRRYIARRKYEQMREEASNILYGYKERRRNSINRNFVGDYL 744

  Fly   761 -------LAQQAAKKRR-EAADKIRAFIKGFITRNDAPNGFNEEFIANAKRMWLL--RLAKELPT 815
                   |.|...|:.| :.||.:..:.:.|       .....:.|.:.|.::|:  ...|:.|.
Frog   745 GMEDRPELRQFMTKRERIDFADSVSKYDRRF-------KSIKRDLILSPKYLYLIGREKVKKGPE 802

  Fly   816 KVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELK-----VLAEKVFK 871
            |          |..:|   ||.:  ::.:..|..:.|:.:|...|.|:     .|.|.|||
Frog   803 K----------GQIKE---ILKK--KVEIMNIQSISLSTRQDDFFILQEVDHDTLMESVFK 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	327/705 (46%)
		MYSc_Myo1	52..707	CDD:276829	316/672 (47%)
		Myosin_TH1	863..1035	CDD:283635	5/14 (36%)
myo1f	XP_002938604.1	MYSc_Myo1	31..677	CDD:276829	316/672 (47%)
		Myosin_TH1	717..915	CDD:368706	31/154 (20%)
		PHA03378	<958..>1041	CDD:223065
		SH3_MyoIe_If_like	1042..1094	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920