DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and myo1c

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_002942189.2	Gene:	myo1c / 100380193	XenbaseID:	XB-GENE-1009886	Length:	1044	Species:	Xenopus tropicalis

Alignment Length:	1037	Identity:	544/1037 - (52%)
Similarity:	722/1037 - (69%)	Gaps:	24/1037 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 QLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYT 88
            ::.||:.|..|||.|||||||||||.||.|||.||:|||:|:|||||||.||:||||||:|.||:
Frog    14 RVTMESALTARDRVGVQDFVLLENYTSEAAFIENLRKRFKENLIYTYIGSVLVSVNPYKELEIYS 78

  Fly    89 DDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSG 153
            ..|::.||...|||:.|||:|:.||::|||..|.:.||:||||||||||||||||:||:.|....
Frog    79 KQHMERYRGVSFYEVSPHIYAIADNSYRSLRTERKDQCILISGESGSGKTEASKKILQYYAVTCP 143

  Fly   154 NQTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRV 218
            ....||.|||:||:|||||||||||||.|||||||||||||:|||:||||:||:|||||||||||
Frog   144 ASDQVETVKDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDYKGAPVGGHILNYLLEKSRV 208

  Fly   219 VAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALT 283
            |.|..||||||||||||.|.:|.||:.|.|::....|.||..|....|:.|||.:.:|.|::||:
Frog   209 VHQNHGERNFHIFYQLLEGGEEDLLRRLGLDKNAQNYQYLVKGQCARVSSINDKNDWKIVRRALS 273

  Fly   284 VIDFTKEEQREIFGIVASILHLGNVGF-TEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRT 347
            :|:|.:::..|:..:|||:||||||.| ::..|:|:|.:.:.:...||||.|:|:.|..:|.|:.
Frog   274 IINFNEDDVEELLSVVASVLHLGNVQFASDDHGHAQVTTENQIKYLARLLAVDAAALRESLIHKK 338

  Fly   348 IDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKET---RASRNNVMGILDI 409
            |.|:|:.:.||||.|.|.|||||||||:|.|.|||||.::|.||..|.:   .....:|:|:|||
Frog   339 IIAKGEELNSPLNLEQAAYARDALAKAIYGRTFSWLVSKINKSLAYKGSDVLSIGNASVIGLLDI 403

  Fly   410 YGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKH 474
            ||||:||.|||||||||:||||||||||||||||||:||..|||.|..|:||:||:||:|:|||.
Frog   404 YGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYESEGIAWESVQYFNNKIICDLVEEKF 468

  Fly   475 KGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539
            ||||||||||||||||.||.||||||...:..|.|:|.|:.....::|.:.||||||:||||||.
Frog   469 KGIISILDEECLRPGEATDMTFLEKLEDTVKNHPHFVTHKLGDQKLRKSLGRDEFRLLHYAGEVN 533

  Fly   540 YSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLKRPETAITQFRASLNNLMDILMC 604
            |||.||||||||||||:|||.:..:||.|...||...||...|||||..|||:.||:.||:|||.
Frog   534 YSVVGFLDKNNDLLFRNLKEVMCDSGNPIAHQCFDRAELTDKKRPETVATQFKNSLSKLMEILMS 598

  Fly   605 KEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKST 669
            |||||:|||||||.:.|..|::.|:.||||||||:||:|||||||||||.||:||:|||||...|
Frog   599 KEPSYVRCIKPNDAKQAARFDEVLIRHQVKYLGLIENVRVRRAGFAYRRKYEIFLQRYKSLCPET 663

  Fly   670 WPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHW 734
            |||:.|..  :.||..|||.||:..|:|::|.||:|||:|:|||.||||.:|:|..||..:||.|
Frog   664 WPNWDGRA--QDGVAVLVKSLGYKPEEYKMGRTKIFIRFPKTLFATEDALEERKQSIATFLQARW 726

  Fly   735 KGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIA 799
            ||.:||:|:|.::...|.:||:.|..:.::.|.||:.|.:.:|.|||||:.||......||.|:.
Frog   727 KGFVQRKKFLHMKHSAIHIQSWWRGNVGRKKAAKRKWAVEVVRRFIKGFVYRNYPRCPENEYFLD 791

  Fly   800 NAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKV 864
            ..:..:|:.|.:.:|..|||||||..|...:|||.:|..:...::..:|..:::|:.|:|.|.||
Frog   792 YIRYSFLMNLRRNMPKSVLDKSWPVPPPSLQEASELLREMCMDNMVWMYCRRISPEMKQQLEQKV 856

  Fly   865 LAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRD 929
            :|.::||.||:||..||...|...|:..|.|   |..:.....::.|.|.....|:||.|||.|.
Frog   857 VASEIFKDKKDNYPQSVPRLFISTRLGNEEI---NTKILQNMENQTLTYAVPVVKYDRKGYKPRR 918

  Fly   930 RFILLSNKAIYVLDGKTYKQKHRLPLDKIDF------TLTNHNDDLMVIRIPLDLKKDKGDLILI 988
            |.:||:..|.|:::....||       :||:      ::::.:|:|.|:.:..:..|.|||::|.
Frog   919 RQLLLTQNAAYIVEEAKLKQ-------RIDYANLTGISVSSLSDNLFVLHVKCEDNKQKGDVVLQ 976

  Fly   989 IPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVKGKGGVIDIQTGAEPGVVRDK-GHLVII 1049
            ...:||..|.|..|......::|: :.|::..|..||.|:||...|:|..:.:.| |||.::
Frog   977 SDHVIETLTKIAITAEKIHNINII-QGSIKFTVGHGKEGIIDFTPGSELLIAKAKNGHLSVV 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	428/691 (62%)
		MYSc_Myo1	52..707	CDD:276829	402/658 (61%)
		Myosin_TH1	863..1035	CDD:283635	55/177 (31%)
myo1c	XP_002942189.2	MYSc_Myo1	43..699	CDD:276829	402/657 (61%)
myo1c	XP_002942189.2	Myosin_TH1	855..1036	CDD:368706	61/191 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	828	1.000	Domainoid score	I66
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H32046
Inparanoid	1	1.050	1045	1.000	Inparanoid score	I263
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D105718at33208
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		otm47630
Panther	1	1.100	-	-	LDO	PTHR13140
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2957
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160