DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myo61F and myo1e.1

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001121497.2	Gene:	myo1e.1 / 100158599	XenbaseID:	XB-GENE-1005591	Length:	1108	Species:	Xenopus tropicalis

Alignment Length:	899	Identity:	366/899 - (40%)
Similarity:	531/899 - (59%)	Gaps:	92/899 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 HERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYR 96
            |....:||.|.|||... :|::.:.|||||:.:|.|:||||.|||||||:||:|.:.|..::.|:
Frog    14 HNVKHSGVDDMVLLSKI-TEDSIVDNLKKRYMDDFIFTYIGPVLISVNPFKQMPYFGDKEIEMYQ 77

  Fly    97 NKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAACSGNQTTVEGV 161
            ....||.||||:|:.||.:|::|.:...|||:||||||:|||.|:|.::.:|:..||....|:.|
Frog    78 GAAQYENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISKVSGGGPKVQHV 142

  Fly   162 KDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGER 226
            ||.:|:|||:|||||||||.||:||||||||.:|||...|.|.||.|.|:||||||||.:..|||
Frog   143 KDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGER 207

  Fly   227 NFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEE 291
            :|||||||:.||.:...:.|.: .:||.|:||....:..|..|||...|::...|:.||..:.|.
Frog   208 SFHIFYQLIEGASKDQRESLGI-TSLDYYNYLNQSGSYKVDDINDKRDFQETMHAMNVIGISAEG 271

  Fly   292 QREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASELEAALTHRTIDA----RG 352
            |..:..|||.:|||||:||.|....|.|.:.:.:...|.|||:|.|.|:..||.|.:|:    :.
Frog   272 QAMVMQIVAGVLHLGNIGFKEKGNYAAVENEEFLAFPAFLLGINQSRLKDKLTSRQMDSKWGGKS 336

  Fly   353 DVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQK 417
            :.:...||.|.|.|.||||:||::.|:|.:||..:|.::  |:.....|  :|:|||||||||||
Frog   337 ESINVTLNVEQACYTRDALSKALHSRVFDYLVDSINKAM--KKDHEEYN--IGVLDIYGFEIFQK 397

  Fly   418 NSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEK--HKGIISI 480
            |.||||||||.||||||:|||||||:||:||.:|||.|.|:|||:||::|:|||.|  ..|::||
Frog   398 NGFEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGVMSI 462

  Fly   481 LDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFRLVHYAGEVTYSV 542
            ||:.|.   ..||..|:|.|:||...:..|.|:....:.            |.:.||||:|:|.|
Frog   463 LDDVCATMHAVGEGADQTLLQKLQMAVGTHEHFNSWNQG------------FIIHHYAGKVSYDV 515

  Fly   543 NGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEKELRSLK--RPETAITQFRASLNNLMDILMCK 605
            :||.::|.|:||.||.|.:..:....::..||| .|::.|  ||.||.::.:...|:|::.||..
Frog   516 DGFCERNRDVLFMDLIELMQSSQQPFMQALFPE-NLQAEKKGRPTTAGSKIKKQANDLVNTLMKC 579

  Fly   606 EPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSKSTW 670
            .|.||||||||:.:....:.:..|.|||:||||.||:||||||:||||.::.||:||..|:|.||
Frog   580 TPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFKKFLQRYAILTKETW 644

  Fly   671 PNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWK 735
            |::|  |..|.||..|:..:..|.:::::|:||:||:.|.:||..|:..:.|....|..||..|:
Frog   645 PSWK--GDEKKGVLHLLHSVNMDSDQFQLGKTKIFIKAPESLFLLEEMRERKYDGYARSIQKAWR 707

  Fly   736 GLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAP---------- 790
            ..:.|:||:::|.|.  ...:..:|      ::||.:.:  |.||..:|..::.|
Frog   708 KYVARKKYVQMREQA--SDLFLNKK------ERRRNSIN--RNFIGDYIGMDERPELRQFVGKRE 762

  Fly   791 ---------------NGFNEEFIANAKRMWLL--RLAKELPTKVLDKSWPHAPGHCEEASGILHR 838
                           .|...:.|...|.::|:  ...|:.|.|.|.|.             :|.:
Frog   763 KIDFADTVTKYDRRSKGVKRDLILTPKSVYLIGRDKMKQGPEKGLVKE-------------VLKK 814

  Fly   839 LHRLHLARIYRLKLTPQQKRQF-----ELKVLAEKVFKGKKNNYASSVSTWFQE 887
              ::.:.||..:.|:..|...|     |...|.|.:|   |..:.|.:|..::|
Frog   815 --KIDVERILSVSLSTMQDDFFILHEQEYDSLLESLF---KTEFISLLSKHYEE 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	325/698 (47%)
		MYSc_Myo1	52..707	CDD:276829	312/665 (47%)
		Myosin_TH1	863..1035	CDD:283635	7/25 (28%)
myo1e.1	NP_001121497.2	MYSc_Myo1	33..679	CDD:276829	312/665 (47%)
		Myosin_TH1	719..921	CDD:368706	33/173 (19%)
		SH3_MyoIe_If_like	1055..1107	CDD:212761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122881at2759
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920