DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and Magi3

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_001152826.1 Gene:Magi3 / 99470 MGIID:1923484 Length:1476 Species:Mus musculus


Alignment Length:189 Identity:38/189 - (20%)
Similarity:65/189 - (34%) Gaps:76/189 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   353 VVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLT 417
            ||.|...|| |..||:.|.:.||.:..:           .||.|       .|::....::.|: 
Mouse    61 VVSGKAPSP-GDVLLEVNGTPVSGLTNR-----------DTLAV-------IRHFREPIRLKTV- 105

  Fly   418 AEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFD 482
                      |.|...:.||...:.|.|:     .||  :||                       
Mouse   106 ----------KPGKVINKDLRHYLSLQFQ-----KGS--IDH----------------------- 130

  Fly   483 NLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLP-LYHEFVNSKHYKSLQ 540
                    .::|||.||:....:.....:|.|.|       :| :.:.|::.:.:|:|:
Mouse   131 --------KLQQVIRDNLYLRTIPCTTRAPRDGE-------VPGVDYNFISVEQFKALE 174

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826
RCC1 114..163 CDD:278826
RCC1 167..218 CDD:278826
RCC1 221..270 CDD:278826
RCC1 273..322 CDD:278826
RCC1_2 309..339 CDD:290274
RCC1 327..390 CDD:278826 11/36 (31%)
HECTc 715..1060 CDD:238033
HECTc 739..1059 CDD:214523
Magi3NP_001152826.1 Interaction with ADRB1 and TGFA. /evidence=ECO:0000269|PubMed:15652357 18..108 17/76 (22%)
PDZ_signaling 24..103 CDD:238492 15/60 (25%)
NK 125..>199 CDD:302627 16/90 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 184..266
WW 297..329 CDD:197736
WW 345..375 CDD:238122
Interaction with PTEN. /evidence=ECO:0000250 413..495
PDZ 416..496 CDD:214570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..575
PDZ 578..659 CDD:214570
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 664..691
PDZ 729..812 CDD:214570
Interaction with ADGRB1. /evidence=ECO:0000250 729..811
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 818..844
PDZ_signaling 851..936 CDD:238492
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250 852..939
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..966
PDZ_signaling 1023..1101 CDD:238492
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1109..1151
MIP-T3 <1166..>1431 CDD:287245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1168..1476
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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