DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and UBE3C

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_055486.2	Gene:	UBE3C / 9690	HGNCID:	16803	Length:	1083	Species:	Homo sapiens

Alignment Length:	954	Identity:	215/954 - (22%)
Similarity:	353/954 - (37%)	Gaps:	292/954 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 TCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNR--------HTLALVPSR-------- 326
            :|..||..|:...|:...:......::....|..:|....        :.|.|:.||
Human   251 SCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNALLLIESRCSRKSGGA 315

  Fly   327 ----------GRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQI 381
                      |..|...|...|.|.........|.|:.:.|   .|.|....::||:
Human   316 PWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSP---ASASCHDSASDSE-------- 369

  Fly   382 FSGGDQSIVTTTLFVDK-VPPEDFRNYNPKSQILTLTAEVTKQCAQ---CKQGLQSDMDLL---S 439
                ::|..     .|| ..|||.|         ...:.:|::|.:   .||...:.::|:   |
Human   370 ----EESEE-----ADKPSSPEDGR---------LSVSYITEECLKKLDTKQQTNTLLNLVWRDS 416

  Fly   440 SIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNI---- 500
            :.|.:|.:.|....:.::.| |.....||      ....||| |.|.:.:      :|..|
Human   417 ASEEVFTTMASVCHTLMVQH-RMMVPKVR------LLYSLAF-NARFLRH------LWFLISSMS 467

  Fly   501 TKELVGSLV--------CSPADVE-SMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRK 556
            |:.:.||:|        .||...| |.|   ::||::.|      .||   |::::..:.:|
Human   468 TRMITGSMVPLLQVISRGSPMSFEDSSR---IIPLFYLF------SSL---FSHSLISIHDN--- 517

  Fly   557 VLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIIL-KLMKT 620
                       |:|...::    ||                .:|:..::|:..|..|:| :.::.
Human   518 -----------EFFGDPIE----VV----------------GQRQSSMMPFTLEELIMLSRCLRD 551

  Fly   621 LCQINNERHDRLNYQIFYWPDLSDYADVQQEYV-----------------------KWIM----- 657
            .|         |......:|:..  .:|::||:                       :||.
Human   552 AC---------LGIIKLAYPETK--PEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVI 605

  Fly   658 ---------ADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGM---- 709
                     .||.|:|...|: ::.:|..    ::||:..|::   ..|:...:.|...|.
Human   606 TNLVKMLKSRDTRRNFCPPNH-WLSEQED----IKADKVTQLY---VPASRHVWRFRRMGRIGPL 662

  Fly   710 -----------PIS-------------QFIV-----------------------------LNVT- 720
                       |:|             .|:|                             :|||
Human   663 QSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTI 727

  Fly   721 -RENLVQDSLRELQHYSQSDLKKPLKIKF---HG--EEAEDAGGVRKEFFMLLLKDLLDPKYGMF 779
             |..:.:|:..:|...::.||||.:::..   ||  |...|.||:.:||...|||...:|..|.|
Human   728 RRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFF 792

  Fly   780 KEYEQSRLLW------------FADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLG 832
            |...:. ||:            ||       ..|:.:|.:.|.|:|...::.|||......||||
Human   793 KTTNEG-LLYPNPAAQMLVGDSFA-------RHYYFLGRMLGKALYENMLVELPFAGFFLSKLLG 849

  Fly   833 --KPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAVT 895
              ..||:..|..|.|....::..|..|: ||.:|: .|.|.:..:..|||:...||..|.:|.||
Human   850 TSADVDIHHLASLDPEVYKNLLFLKSYE-DDVEEL-GLNFTVVNNDLGEAQVVELKFGGKDIPVT 912

  Fly   896 LENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNE-DYDWQALQ 959
            ..||..::.|..|:..|:.:..|..||.:|...|.|...:.:|..:|:..::.|.: ....:.|:
Human   913 SANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLK 977

  Fly   960 DNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT------ 1018
            ....|..||::....||.||.|:...::.||:..|.|:|...|.|:.|.|.|    .|.
Human   978 SFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKEL----YPAFCIHNG 1038

  Fly  1019 -PDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
             .|...||.|.||.|||.||.:..:..|:.|||.||:...||.|
Human  1039 GSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFEL 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	8/51 (16%)
		RCC1_2	309..339	CDD:290274	9/55 (16%)
		RCC1	327..390	CDD:278826	13/62 (21%)
		HECTc	715..1060	CDD:238033	115/402 (29%)
		HECTc	739..1059	CDD:214523	107/346 (31%)
UBE3C	NP_055486.2	Cis-determinant of acceptor ubiquitin-binding	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		IQ	47..64	CDD:197470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..385		11/49 (22%)
		HECTc	725..1081	CDD:238033	113/369 (31%)
		HECTc	747..1080	CDD:214523	107/346 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810