DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Hecw1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_006516872.1	Gene:	Hecw1 / 94253	MGIID:	2444115	Length:	1605	Species:	Mus musculus

Alignment Length:	848	Identity:	197/848 - (23%)
Similarity:	333/848 - (39%)	Gaps:	201/848 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 EMLPRMVMELMGSTITQVA---CGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIG 356
            |.|.|....:..:..|:.|   .||::: ..:|..|   ..|.|.|......|..||.|.:
Mouse   877 EQLNRRYQNIQRTMATERAEEDSGNQNS-EQIPDGG---GGGGGGSDSEAESSQSSLDLRR---- 933

  Fly   357 PWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDF----RNYNP-------- 409
                 .|| |...|..:|:|:::.          ....|:..  ||.|    .||:.
Mouse   934 -----EGS-LSPVNSQKVTLLLQS----------PAVKFITN--PEFFTVLHANYSAYRVFTSST 980

  Fly   410 --KSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQ----ACW-------NGSFLLDHDR 461
              |..||.:     ::.|:..:..|.:.||::.|.:...::    ..|       ..||.:||:
Mouse   981 CLKHMILKV-----RRDARNFERYQHNRDLVNFINMFADTRLELPRGWEIKTDHQGKSFFVDHN- 1039

  Fly   462 HFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIW----------DNITKELVGSLVCSP---- 512
                   :........::...|.|...:.:.||.:.          ..:::....||:..|
Mouse  1040 -------SRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRNRGASLLARPGHSL 1097

  Fly   513 -ADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQN 576
             |.:.|...:..|||.:   |.|....|:.|   .||::.:.          :.|:....|.::.
Mouse  1098 IAAIRSQHQHESLPLAY---NDKIVAFLRQP---NIFEMLQE----------RQPSLARNHTLRE 1146

  Fly   577 FLHVVIHIISFKMGLAAASPSAERRQQL--LPYNTELEIILKLMKTLCQINNERHDRLNYQIFYW 639
            .:|.:               ..|....|  |..:.:|.|:|.|.:
Mouse  1147 KIHYI---------------RTEGNHGLDKLSCDADLVILLSLFE-------------------- 1176

  Fly   640 PDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMA------NAA 698
            .::..|..:|..:..             .||| ..:.:..:..|....||..||.|      :..
Mouse  1177 EEIMSYVPLQSAFHP-------------GYSF-SPRCSPCSSPQNSPGLQRASARAPSPYRRDFE 1227

  Fly   699 TMAFSFF------NYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKK-PLKIKFHGEEAEDA 756
            ....:|:      .:|....: |.|.:.|::|::.:..::..||:.:|:: .|.|.|.|||..|.
Mouse  1228 AKLRNFYRKLEAKGFGQGPGK-IKLIIRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDY 1291

  Fly   757 GGVRKEFFMLLLKDLLDPKYGMFKEYE----------------QSRLLWFADLTFETENMYFLIG 805
            .|..:|||.||.::|.:|.||:| ||.                ::.|.||.           ..|
Mouse  1292 SGPSREFFFLLSQELFNPYYGLF-EYSANDTYTVQISPMSAFVENYLEWFR-----------FSG 1344

  Fly   806 VLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTF 870
            .:.|||:.:..:::..|....:|.||..|.|||||..|......|:|.:.|   ::..::.||||
Mouse  1345 RILGLALIHQYLLDAFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKD---NNITDILDLTF 1406

  Fly   871 EISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVI 935
            .::.:|||:...:.||..|....||.:|::|:::..|.:...:.|.....|..:||.:|...|::
Mouse  1407 TVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVERGVVQQTEALLRGFYEVVDSRLV 1471

  Fly   936 HIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGS 1000
            .:|...||..|:.|..:.|....::|.|||.||......|:|||..:...:..::...|.|:||:
Mouse  1472 SVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLRLLQFVTGT 1536

  Fly  1001 DRIPIQGMKAL-------KLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQG 1058
            ..:|.:|..||       :..|:.......||.||||||.||||.|.:...|..|||.|:::|..
Mouse  1537 SSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETST 1601

  Fly  1059 FSL 1061
            |.|
Mouse  1602 FGL 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	7/29 (24%)
		RCC1_2	309..339	CDD:290274	9/32 (28%)
		RCC1	327..390	CDD:278826	14/62 (23%)
		HECTc	715..1060	CDD:238033	113/368 (31%)
		HECTc	739..1059	CDD:214523	107/343 (31%)
Hecw1	XP_006516872.1	HECW_N	66..185	CDD:374632
		C2_NEDL1-like	206..342	CDD:176073
		Neuromodulin	378..500	CDD:369001
		WW	829..858	CDD:366073
		HECW1_helix	947..1013	CDD:375862	15/82 (18%)
		WW	1019..1050	CDD:197736	5/38 (13%)
		HECTc	1249..1603	CDD:238033	113/368 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810