DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and TRIP12

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	402	Identity:	107/402 - (26%)
Similarity:	177/402 - (44%)	Gaps:	71/402 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   719 VTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFK--- 780
            |.||.|::.:...:|....|  :..|:|::..|.....|.. .||:.|:.::|.....|:::
Human  1693 VNREELLKQAESVMQDLGSS--RAMLEIQYENEVGTGLGPT-LEFYALVSQELQRADLGLWRGEE 1754

  Fly   781 -------------EYEQSRLLWFADLTF----------ETENMYFLIGVLCGLAIYNFTIINLPF 822
                         :|.|:....|| |.|          :.:..:..:|.|...||.:|.:::||.
Human  1755 VTLSNPKGSQEGTKYIQNLQGLFA-LPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPL 1818

  Fly   823 PLALFKKLLGKPVDLS--DLRQLSPPEANSMQSL---------LDYQGDDFKE------------ 864
            .|..:|.:|.:...|:  ||..:.|..|.|:..|         |:......||
Human  1819 GLPFYKWMLRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMN 1883

  Fly   865 ---VFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGF 926
               |.||..:.:...|...|   ||..|.:|.||:.|.:|::.|.:.:..|:.|...:::|..||
Human  1884 GCSVEDLGLDFTLPGFPNIE---LKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGF 1945

  Fly   927 MKVCSGRVIHIFQPEELMAVVVGNEDYDWQA--LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAE 989
            ..|.....:..|.||||..::.|::...|.|  |.:.|....|||.....:|:.:|::......:
Human  1946 ESVFPLSHLQYFYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQ 2010

  Fly   990 KKSFLLFLTGSDRIPIQGMKALK--LTI-------QPTPDERFLPVAHTCFNLLDLPRYKTKERL 1045
            ::.||.|:|||.|:|:.|.::|.  |||       ...||: |||...||.|.|.||.|.:.|.:
Human  2011 QRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDD-FLPSVMTCVNYLKLPDYSSIEIM 2074

  Fly  1046 KYKLLQAIQQTQ 1057
            :.|||.|.::.|
Human  2075 REKLLIAAREGQ 2086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	107/402 (27%)
		HECTc	739..1059	CDD:214523	101/382 (26%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680
		Arm_3	489..>714	CDD:330530
		WWE	808..874	CDD:308464
		HECTc	1690..2090	CDD:238033	107/402 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900