DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and RCCD1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001017919.1	Gene:	RCCD1 / 91433	HGNCID:	30457	Length:	376	Species:	Homo sapiens

Alignment Length:	383	Identity:	103/383 - (26%)
Similarity:	150/383 - (39%)	Gaps:	64/383 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGH 74
            :|....|| .||.....|:.:||  |......:.:|:....:|.|:|..|::...||..    |.
Human    12 FGFCGFGQ-ELGSGRGRQVHSPS--PLRAGVDICRVSASWSYTAFVTRGGRLELSGSAS----GA 69

  Fly    75 DLPTKRPRMSPFLLI-------PELQDYVIIQICCGSRHSLALSDWGQ-VLSWGDNDCGQLGHAT 131
            ....|....|..||.       ||    .::|:............|.| |:...:.:....|.|.
Human    70 AGRCKDAWASEGLLAVLRAGPGPE----ALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130

  Fly   132 DKEIVQLPKVVRQLVTKTVV------------QIACGNNHSLALTSCGELYSWGSNIYGQLGVNS 184
            ...:..|| ..|..|:....            |:..|..|:|.|.:.|:::|||...:||||..:
Human   131 AGRLPLLP-CARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT 194

  Fly   185 PNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQL 249
               |.....|..|..|.|:.:|.:|.||.||..:|::|.::.||.|..|||.|        ||
Human   195 ---LEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLAL--------PT-- 246

  Fly   250 KTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVAC 314
            :.|...|........|    |..:|.......||.......|.:.:..|.::...|||...:.:|
Human   247 RNLAEDGETVAREATE----LNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASC 307

  Fly   315 GNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQ--------------VVIGPW 358
            |:||| |:|...|.:|.:|.|..||||...|.||..|:              |..|||
Human   308 GSRHT-AVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPW 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	11/44 (25%)
		RCC1	59..110	CDD:278826	11/57 (19%)
		RCC1	114..163	CDD:278826	12/61 (20%)
		RCC1	167..218	CDD:278826	19/50 (38%)
		RCC1	221..270	CDD:278826	13/48 (27%)
		RCC1	273..322	CDD:278826	13/48 (27%)
		RCC1_2	309..339	CDD:290274	11/29 (38%)
		RCC1	327..390	CDD:278826	16/46 (35%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
RCCD1	NP_001017919.1	Interaction with KDM8. /evidence=ECO:0000269\|PubMed:24981860	1..169		35/168 (21%)
		ATS1	<156..340	CDD:227511	63/201 (31%)
		RCC1 2	176..227		19/53 (36%)
		RCC1 3	229..317		29/102 (28%)
		RCC1 4	318..371		16/47 (34%)
		RCC1	319..366	CDD:395335	16/46 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010