DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and HERC3

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_055421.1 Gene:HERC3 / 8916 HGNCID:4876 Length:1050 Species:Homo sapiens


Alignment Length:1078 Identity:477/1078 - (44%)
Similarity:668/1078 - (61%) Gaps:52/1078 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :.|||..|.||.|:.......:..|....:..|.:|::||||..|::||...|:||.||.|...|
Human     1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQ 65

  Fly    72 LGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIV 136
            |||:....:|..     |..|.|..||.:.||..|||||||.||:.|||....||||..|.::.|
Human    66 LGHEREGNKPEQ-----IGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSV 125

  Fly   137 QLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNS--PNDLTHCNYPLRLTT 199
            .:|:::::|..:|::|::|||.|.|||.:.|:.::||.|.:||||:..  |:..:    |.|:.:
Human   126 AVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS----PQRVRS 186

  Fly   200 LLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGD 264
            |.|||||.:|.||.|||.:|.||||||||.||.|||||:||.:|..|..:|.|||..|.:::||:
Human   187 LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGE 251

  Fly   265 EFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRV 329
            |.:..||..|||||.|||:.|||||...::|:.||.|:|||||.:||:|||.:||||.|||.|.:
Human   252 EHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLI 316

  Fly   330 YAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTL 394
            ||||.|:.|||||..|.::..|..|.|.|.:.||....:::..:.. :::||||||||:.|..:.
Human   317 YAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYH-IVKQIFSGGDQTFVLCSK 380

  Fly   395 FVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDH 459
            :.:..|..|||..| ::...:|..:.|....:.|....::.:.::.:..|..|.||||||||...
Human   381 YENYSPAVDFRTMN-QAHYTSLINDETIAVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKK 444

  Fly   460 -DRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLL 523
             |.||..|.:..|:||.:.::.|:.|...::..|.:.|.::....|:..|..||.|||:||:||:
Human   445 IDEHFKTSPKIPGIDLNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLI 509

  Fly   524 LPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFK 588
            ||.:....:||:|.:|.:|.|.||.:|..||.|||:.|.:|...:||..||..:...|::::   
Human   510 LPEFPLLQDSKYYITLTIPLAMAILRLDTNPSKVLDNWWSQVCPKYFMKLVNLYKGAVLYLL--- 571

  Fly   589 MGLAAASPSAERRQQLLP--YNTELEIILKLMKTLCQIN-NERHDRLNYQIFYWPDLSDYADVQQ 650
                     ..|:..|:|  :|..:...|||::.|.::| ..:|  :.|..||.|::|:..|:|:
Human   572 ---------RGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKH--VEYDTFYIPEISNLVDIQE 625

  Fly   651 EYVKW------------IMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFS 703
            :|:.|            |:.||.   .:|:|.||||..|||.:||.|..|||..|: |.|.:...
Human   626 DYLMWFLHQAGMKARPSIIQDTV---TLCSYPFIFDAQAKTKMLQTDAELQMQVAV-NGANLQNV 686

  Fly   704 FFNYGM-PI---SQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFF 764
            |....: |:   |.|:||:|.|.|||.|:||||..:|..|||||||:.|.||||.|||||.||||
Human   687 FMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDGEEAVDAGGVTKEFF 751

  Fly   765 MLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKK 829
            :||||:||:|.||||..|:.|.||||:|..|...|.:.|||:.|||||||.|:::|.|||||:||
Human   752 LLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKK 816

  Fly   830 LLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAV 894
            ||.....|.||::|||.|..|:|.||||.|:|.:|.|.|.|.|.|:.:|..|.|.|.|.|:.:.|
Human   817 LLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEETFCLNFTICRESYGVIEQKKLIPGGDNVTV 881

  Fly   895 TLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQ 959
            ..:|||||||.||::||..||...|.||..||:|||.|:|:.:|||.||.|::|||.:|:|:.|:
Human   882 CKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELE 946

  Fly   960 DNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPTPD-ERF 1023
            :...|:..|::...|:|.|||..|:....:||.|||||||||||||.||.:|::.||.|.. |.:
Human   947 ETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIVIQSTASGEEY 1011

  Fly  1024 LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            |||||||:||||||:|.:||.|..:|.||:...:||||
Human  1012 LPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826 15/47 (32%)
RCC1 59..110 CDD:278826 21/50 (42%)
RCC1 114..163 CDD:278826 20/48 (42%)
RCC1 167..218 CDD:278826 23/52 (44%)
RCC1 221..270 CDD:278826 27/48 (56%)
RCC1 273..322 CDD:278826 30/48 (63%)
RCC1_2 309..339 CDD:290274 18/29 (62%)
RCC1 327..390 CDD:278826 26/62 (42%)
HECTc 715..1060 CDD:238033 189/345 (55%)
HECTc 739..1059 CDD:214523 175/320 (55%)
HERC3NP_055421.1 RCC1 1 1..51 17/49 (35%)
ATS1 2..331 CDD:227511 162/337 (48%)
RCC1 2 52..101 23/53 (43%)
RCC1 3 102..154 22/51 (43%)
RCC1 4 156..207 23/54 (43%)
RCC1 5 208..259 28/50 (56%)
RCC1 6 261..311 31/49 (63%)
RCC1 313..377 CDD:366085 26/64 (41%)
RCC1 7 313..366 18/53 (34%)
HECTc 702..1048 CDD:238033 189/345 (55%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 353 1.000 Domainoid score I1009
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 909 1.000 Inparanoid score I368
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57432
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 1 1.000 - - FOG0001110
OrthoInspector 1 1.000 - - otm41232
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45622
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R774
SonicParanoid 1 1.000 - - X678
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.970

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