DRSC/TRiP Functional Genomics Resources

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Protein Alignment Herc4 and UFD4

DIOPT Version :9

Sequence 1:NP_001261249.1 Gene:Herc4 / 38151 FlyBaseID:FBgn0035207 Length:1062 Species:Drosophila melanogaster
Sequence 2:NP_012915.3 Gene:UFD4 / 853859 SGDID:S000001493 Length:1483 Species:Saccharomyces cerevisiae


Alignment Length:1327 Identity:260/1327 - (19%)
Similarity:442/1327 - (33%) Gaps:500/1327 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ACGS---NDYSQLGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDC 124
            ||.|   :|:..:...|||.:|      :.....|..|:.....:.:.:               |
Yeast   329 ACSSIRTDDFKTIVEVLPTLKP------IFSNATDQPILTRLVNAMYGI---------------C 372

  Fly   125 GQLGHATDK-----------EIVQLPKV-------------------------VRQLVTKT-VVQ 152
            |.| |..||           .||||..:                         .|:|..|| :|.
Yeast   373 GAL-HGVDKFETLFSLDLIERIVQLVSIQDTPLENKLKCLDILTVLAMSSDVLSRELREKTDIVD 436

  Fly   153 IACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFL 217
            :|         |...:.||           .|||...|       .||:.:|         :|.|
Yeast   437 MA---------TRSFQHYS-----------KSPNAGLH-------ETLIYVP---------NSLL 465

  Fly   218 ISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAG 282
            ||.|                                    ||:..     :|...:..:.:  |.
Yeast   466 ISIS------------------------------------RFIVV-----LFPPEDERILS--AD 487

  Fly   283 AY-GQLGHGFSSNE---------MLPRMV------------MELMGSTITQVACGNRHTL----- 320
            .| |....|..||:         ::|.:|            ..::.:.:..|:|.|..|.     
Yeast   488 KYTGNSDRGVISNQEKFDSLVQCLIPILVEIYTNAADFDVRRYVLIALLRVVSCINNSTAKAIND 552

  Fly   321 ALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGG 385
            .|:...|.:.|....:|...||.|:::                ..||....|.:.|:.::.    
Yeast   553 QLIKLIGSILAQKETASNANGTYSSEA----------------GTLLVGGLSLLDLICKKF---- 597

  Fly   386 DQSIVTTTLFVDKVPPE-----------DFRNYNPK---SQILTLTAE---VTKQCAQCKQGLQ- 432
                  :.||...:..|           ||.|.:.|   ::.::|:.|   :.....:|.:|.: 
Yeast   598 ------SELFFPSIKREGIFDLVKDLSVDFNNIDLKEDGNENISLSDEEGDLHSSIEECDEGDEE 656

  Fly   433 -----SDMDLLSSIE------LIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLAFDNLRA 486
                 :||::..|::      .|||:.:.              ..::|.|::|....|:..|   
Yeast   657 YDYEFTDMEIPDSVKPKKISIHIFRTLSL--------------AYIKNKGVNLVNRVLSQMN--- 704

  Fly   487 VENESIRQVIWDNITKEL-----VGSLVCSPA-------DVESMRLYLLLPLYHEFVNSKHYKSL 539
            ||.|:        ||:||     |.|::.:|:       |.:.:...|...::||..:...::..
Yeast   705 VEQEA--------ITEELHQIEGVVSILENPSTPDKTEEDWKGIWSVLKKCIFHEDFDVSGFEFT 761

  Fly   540 QVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHV----VIHIISFKM---GL---AAA 594
            ....|::|.|...: ..|.:..||::..|.||..:..||.:    :..:.:|.:   ||   ...
Yeast   762 STGLASSITKRITS-STVSHFILAKSFLEVFEDCIDRFLEILQSALTRLENFSIVDCGLHDGGGV 825

  Fly   595 SPSAERRQQLLPYN---------TEL-------------------------------EIILKLMK 619
            |..|:..:..|.|:         |:|                               .:|..|..
Yeast   826 SSLAKEIKIKLVYDGDASKDNIGTDLSSTIVSVHCIASFTSLNEFLRHRMVRMRFLNSLIPNLTS 890

  Fly   620 TLCQINNERHD-------RLNYQIFY-----------------------------WPDL------ 642
            :..:.:.|..:       :.|:..||                             |.|.      
Yeast   891 SSTEADREEEENCLDHMRKKNFDFFYDNEKVDMESTVFGVIFNTFVRRNRDLKTLWDDTHTIKFC 955

  Fly   643 ---------SDYADVQQE-------YVK--WIMADTARDFNI---------CNY---SFIFDQ-S 676
                     |:.|:...|       |.|  :...||....:|         |..   |||..: |
Yeast   956 KSLEGNNRESEAAEEANEGKKLRDFYKKREFAQVDTGSSADILTLLDFLHSCGVKSDSFINSKLS 1020

  Fly   677 AKTALLQADQALQMHSAMANAA--------TMAFSF---------------FNYGMPISQF---- 714
            ||.| .|.|:.|    .:|:.|        |..|.|               |.||..|..:    
Yeast  1021 AKLA-RQLDEPL----VVASGALPDWSLFLTRRFPFLFPFDTRMLFLQCTSFGYGRLIQLWKNKS 1080

  Fly   715 --------------------IVLNVTRENLVQDSLRELQHYSQS-DLKKPLKIKFHGEEAEDAGG 758
                                ..|.::|:.:....|:.|..|..| |:   |:|::. |||....|
Yeast  1081 KGSKDLRNDEALQQLGRITRRKLRISRKTIFATGLKILSKYGSSPDV---LEIEYQ-EEAGTGLG 1141

  Fly   759 VRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYF--------------------- 802
            ...||:.::.|........|::....|   :.:::..:|.:.|.                     
Yeast  1142 PTLEFYSVVSKYFARKSLNMWRCNSYS---YRSEMDVDTTDDYITTLLFPEPLNPFSNNEKVIEL 1203

  Fly   803 --LIGVLCGLAIYNFTIINLPFPLALFKKLLGK---------PVDLSD----LRQLSPPEANSMQ 852
              .:|.....::.:..|::..|....| :||.:         |.|:..    :..:.|..|.|::
Yeast  1204 FGYLGTFVARSLLDNRILDFRFSKVFF-ELLHRMSTPNVTTVPSDVETCLLMIELVDPLLAKSLK 1267

  Fly   853 SLLDYQGDDFK-EVFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVE 916
            .::..:.|:.. |...|||.:.    |..:.: |.|.|...::...|.:|::...:|.:..|.:|
Yeast  1268 YIVANKDDNMTLESLSLTFTVP----GNDDIE-LIPGGCNKSLNSSNVEEYIHGVIDQILGKGIE 1327

  Fly   917 LHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQ--ALQDNCEYREGYTSVDDTIKWFW 979
            ....||.:||.||.|...:.|..|:||:. :.|..:.||.  .|..|.....|||.....|..|.
Yeast  1328 KQLKAFIEGFSKVFSYERMLILFPDELVD-IFGRVEEDWSMATLYTNLNAEHGYTMDSSIIHDFI 1391

  Fly   980 EVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTI-------QPTPDERFLPVAHTCFNLLD 1035
            .:|....:.|::.||.|||||.::||.|.|:|  |.|:       ..|.|| :||...||.|.|.
Yeast  1392 SIISAFGKHERRLFLQFLTGSPKLPIGGFKSLNPKFTVVLKHAEDGLTADE-YLPSVMTCANYLK 1455

  Fly  1036 LPRYKTKERLKYKLLQAIQQTQGFSLV 1062
            ||:|.:|:.::.:|.|||::..|..|:
Yeast  1456 LPKYTSKDIMRSRLCQAIEEGAGAFLL 1482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Herc4NP_001261249.1 RCC1 6..55 CDD:278826
RCC1 59..110 CDD:278826 10/49 (20%)
RCC1 114..163 CDD:278826 16/85 (19%)
RCC1 167..218 CDD:278826 10/50 (20%)
RCC1 221..270 CDD:278826 3/48 (6%)
RCC1 273..322 CDD:278826 12/75 (16%)
RCC1_2 309..339 CDD:290274 8/34 (24%)
RCC1 327..390 CDD:278826 10/62 (16%)
HECTc 715..1060 CDD:238033 100/393 (25%)
HECTc 739..1059 CDD:214523 93/367 (25%)
UFD4NP_012915.3 HUL4 581..1482 CDD:227354 196/956 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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