DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and HUL4

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_012570.3	Gene:	HUL4 / 853494	SGDID:	S000003797	Length:	892	Species:	Saccharomyces cerevisiae

Alignment Length:	669	Identity:	197/669 - (29%)
Similarity:	320/669 - (47%)	Gaps:	111/669 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   465 CSVRNHGLDLKAAQLAFD--NLRAVENESIRQVI--WDNI----TKELVGSLVCSPAD-----VE 516
            |.:|:     :.::..|:  .:|||..|..::.|  ..|:    :::|:.||..:|.|     ||
Yeast   258 CLIRD-----RKSKNVFETQQIRAVSYELAKRCIGYLSNLSTKTSQQLIQSLRRTPTDNFSYQVE 317

  Fly   517 SMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVL-----------NKWLAQTP--AE 568
            .:.||         :|.:..:.|....:|...|....|...:           :::|:..|  |:
Yeast   318 ILNLY---------INFQFSRLLSNELSNRTAKNNVKPEDEMRSRLRRHHTTGHEFLSTRPISAQ 373

  Fly   569 YFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEI--ILKLMKTLCQINNERHDR 631
            ..:.....|.|.|.:.:.||               ...|..:..|  ..||.......|..|:.|
Yeast   374 SNDKQGSGFTHPVNNKMKFK---------------FFQYEEDWHIHSAAKLTFIYYVANTRRNGR 423

  Fly   632 --LNYQIFYWPDLSDYADVQQEY----------------VKWIMADTARDFNICNYSFIFDQSAK 678
              |:.|.||...| |:.|.:|::                .:|..:.|.:.|:.|.|.||.....|
Yeast   424 GALSIQSFYNITL-DFIDYKQDFDHWRGVAQKTKMNQLIEEWGNSTTKKCFSFCKYPFILSLGIK 487

  Fly   679 TALLQADQALQMHSAMANAATMAFSF-FNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKK 742
            .::::    .::...|.:.|..||.. .:.|..:..:..:.|.|:.:..||||.::.: |.||.|
Yeast   488 ISIME----YEIRRIMEHEAEQAFLISLDKGKSVDVYFKIKVRRDVISHDSLRCIKEH-QGDLLK 547

  Fly   743 PLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFA--DLTFETE------- 798
            .|:|:|..|...||||:|||:|.||.|.|.:|..|:|...::|...|||  ...|:..
Yeast   548 SLRIEFVNEPGIDAGGLRKEWFFLLTKSLFNPMNGLFIYIKESSRSWFAIDPPNFDKSKGKNSQL 612

  Fly   799 NMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFK 863
            .:|:|.||:.||||:|.||::|.||.||:|||..:|:...|..:|.|..:.::..:|:|..|:|:
Yeast   613 ELYYLFGVVMGLAIFNSTILDLQFPKALYKKLCSEPLSFEDYSELFPETSRNLIKMLNYTEDNFE 677

  Fly   864 EVFDLTFE--------ISRDVFGEAE--TKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELH 918
            :||.||||        |..|.....|  |..|..||..:.:|..|:.|||..:|:|...||:|..
Yeast   678 DVFSLTFETTYRNNNWILNDSKSSKEYVTVELCENGRNVPITQSNKHEFVMKWVEFYLEKSIEPQ 742

  Fly   919 YNAFHKGFMKV---CSGRVIHIFQPEELMAVVVGNED---YDWQALQDNCEYREGYTSVDDTIKW 977
            ||.|..||.:|   |:.  |.:|..|||..:|.|:|:   :|:::|:...:|..|::.....:.|
Yeast   743 YNKFVSGFKRVFAECNS--IKLFNSEELERLVCGDEEQTKFDFKSLRSVTKYVGGFSDDSRAVCW 805

  Fly   978 FWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKAL--KLTIQPTPDERFLPVAHTCFNLLDLPRYK 1040
            |||:|.......:|..|.|:|.|||||..|:..:  |:::..:.|...||:||||||.:.|..|.
Yeast   806 FWEIIESWDYPLQKKLLQFVTASDRIPATGISTIPFKISLLGSHDSDDLPLAHTCFNEICLWNYS 870

  Fly  1041 TKERLKYKLLQAIQQTQGF 1059
            :|::|:.|||.||.:::|:
Yeast   871 SKKKLELKLLWAINESEGY 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	138/372 (37%)
		HECTc	739..1059	CDD:214523	130/346 (38%)
HUL4	NP_012570.3	HUL4	1..892	CDD:227354	197/669 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344689
Domainoid	1	1.000	197	1.000	Domainoid score	I587
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2533
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46778
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R774
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720