DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and HUL5

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_011374.1	Gene:	HUL5 / 852736	SGDID:	S000003109	Length:	910	Species:	Saccharomyces cerevisiae

Alignment Length:	783	Identity:	191/783 - (24%)
Similarity:	309/783 - (39%)	Gaps:	173/783 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 GTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFR 405
            |.::...|::|.  ....::||   :|:|::..|.....:.|.  |:.|.||..:|
Yeast   238 GQKNIAKLLIPN--FNNHIAPS---VLRSDNDYVLKFYEKAFI--DEVIATTANYV--------- 286

  Fly   406 NYNPKSQILTLTAEVTKQCAQ-CKQGLQSDMDLLSSIELIFRSQACW-------NGSFLLDH--- 459
              :.:..:..|...:.....| ||..:.  :.|||:.:.:.|  ..|       |.|....|
Yeast   287 --SDEDHVKNLMCYIASSPNQSCKNSVL--ITLLSNKDFVRR--LSWEFFHTKFNASKTEAHPLF 345

  Fly   460 -------DRHFGCSVRNHGLDLKAAQLAFDNLR----AVENESIRQVIWD-------NITKELVG 506
                   |.|...|.....||..:. :..:.|:    .:::.:.|| .|:       .:.||.|.
Yeast   346 SVLAQLIDMHLLISTDRELLDYNSV-IPIEELKKFTSTLKDFTFRQ-YWELPKSERNPMLKEAVP 408

  Fly   507 SLVCSPADVESMRLYLLL----PLYHE-----FVNSKHYKSLQVPFANAIFKLAENPRKVLNKWL 562
            .|  |.......||:.|.    |.|.|     |:|.:.|:.||
Yeast   409 LL--SKVYERDSRLHFLSTENNPTYWENSEKQFLNLRFYEELQ---------------------- 449

  Fly   563 AQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIIL--KLMKTLCQIN 625
             :....|.|||.:.                 :....|:...|......|:.:|  |:.|.|....
Yeast   450 -EYEDLYREHLEEE-----------------SDEDMEKEIDLDKERPPLKSLLLNKMKKRLKSSL 496

  Fly   626 NERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTAR-----DFNICNYSFIFDQSAKTALLQAD 685
            ..|...:..::.::....:..|:   :..:|..|..|     |.|:.|   :|...|.|
Yeast   497 RFRKLEILLELPFFIPFEERVDL---FYMFIALDKKRLSLDDDHNLIN---MFTPWAST------ 549

  Fly   686 QALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKF-- 748
             .::..||:                        ::|:|:::|:........:. .|..|.:.|
Yeast   550 -GMRKQSAI------------------------ISRDNVLEDAFNAFNSIGER-FKASLDVTFIN 588

  Fly   749 -HGEEAE-DAGGVRKEFFMLLLKD-LLDPKYGMFKEYEQSRLLWFADLTFETENMYFL--IGVLC 808
             .||||. |.||:.|||...:..: ..|||:.:|:..::..|  :..:.::...:.::  :|.:.
Yeast   589 EFGEEAGIDGGGITKEFLTTVSDEGFKDPKHELFRTNDRYEL--YPSVVYDATKLKYIWFLGKVV 651

  Fly   809 GLAIYNFTIINLPFPLALFKKLL----GKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLT 869
            |..:|...:|::.|.....||||    |.....|||........|::..||:...|:.|.: |||
Yeast   652 GKCLYEHVLIDVSFADFFLKKLLNYSNGFLSSFSDLGSYDSVLYNNLIKLLNMTTDEIKSL-DLT 715

  Fly   870 FEISRDVFGEAETKC--LKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSG 932
            |||...   |:..|.  |.|||::..||.:|...:|....|:..||......:|||.|...:.:.
Yeast   716 FEIDEP---ESSAKVVDLIPNGSKTYVTKDNVLLYVTKVTDYKLNKRCFKPVSAFHGGLSVIIAP 777

  Fly   933 RVIHIFQPEELMAVVVGNED-YDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLF 996
            ..:.:|...||..::.|..| .|...|:.|.|| .||...|.||..||||:::....||.:||.|
Yeast   778 HWMEMFNSIELQMLISGERDNIDLDDLKSNTEY-GGYKEEDQTIVDFWEVLNEFKFEEKLNFLKF 841

  Fly   997 LTGSDRIPIQGMKAL--KLTIQPTPDERF-LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQG 1058
            :|...:.|:||.|||  |..|:....|:: ||.|.||.|||.||.|:.|..|:.|||.||.....
Yeast   842 VTSVPQAPLQGFKALDPKFGIRNAGTEKYRLPTASTCVNLLKLPDYRNKTILREKLLYAINSGAR 906

  Fly  1059 FSL 1061
            |.|
Yeast   907 FDL 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826	10/48 (21%)
		HECTc	715..1060	CDD:238033	114/361 (32%)
		HECTc	739..1059	CDD:214523	111/336 (33%)
HUL5	NP_011374.1	HUL4	35..910	CDD:227354	191/783 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810