DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and FMP25

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_013178.1	Gene:	FMP25 / 850766	SGDID:	S000004067	Length:	583	Species:	Saccharomyces cerevisiae

Alignment Length:	324	Identity:	73/324 - (22%)
Similarity:	122/324 - (37%)	Gaps:	86/324 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VQQVACGHRHTLFLTATGKVYACGS-NDYSQL-----GHDLPTKRPRMSPFLLIPELQDYVIIQI 100
            |.|...|..|.:.|:..||.|.|.: ||..|.     ...:||    .|.|...|.......|::
Yeast   297 VVQFDAGSHHLVLLSNLGKAYCCATGNDQKQAQVSKGQFGIPT----FSQFDEFPPNNQLFEIEL 357

  Fly   101 CCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTS 165
            ....:|.            |::                  |||:   :.:.:||||:.|:||:..
Yeast   358 LNKFKHE------------GED------------------VVRK---REIKKIACGSYHTLAIDK 389

  Fly   166 CGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRN 230
            .||:|::|.|.:|||.:....:|.:.::|..:|               |:|.....| :..|
Yeast   390 TGEIYAFGWNRFGQLALPISYNLEYVSFPRSVT---------------HAFKPHFPG-MTNW--- 435

  Fly   231 NCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNE 295
            .|..:..:|||:      ..|:|..|             .|::...|..|.|.:|:||:....|.
Yeast   436 KCVDIHCDDETS------FVTIRKPG-------------STSDHHYFAFGNGLFGELGNNTFKNS 481

  Fly   296 MLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLG-----TRSTKSLMLPQVV 354
            ....:.::.....:|..:||:............|.|:|....||||     .:..|.:.:|:|:
Yeast   482 QCDPIKIKSDDKKLTNWSCGSHCVFTETEQENEVIAWGNNDHGQLGIGKKTMKCAKPMNIPEVL 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	4/12 (33%)
		RCC1	59..110	CDD:278826	14/56 (25%)
		RCC1	114..163	CDD:278826	10/48 (21%)
		RCC1	167..218	CDD:278826	13/50 (26%)
		RCC1	221..270	CDD:278826	9/48 (19%)
		RCC1	273..322	CDD:278826	10/48 (21%)
		RCC1_2	309..339	CDD:290274	6/29 (21%)
		RCC1	327..390	CDD:278826	10/33 (30%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
FMP25	NP_013178.1	ATS1	8..577	CDD:227511	73/324 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910