DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and PRAF1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_565144.1	Gene:	PRAF1 / 844030	AraportID:	AT1G76950	Length:	1103	Species:	Arabidopsis thaliana

Alignment Length:	805	Identity:	179/805 - (22%)
Similarity:	317/805 - (39%)	Gaps:	143/805 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELYCWGSTSHGQLGLGGIEDE--------QILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVY 62
            ::|.||......:...||:..        .:|.|..:.......|.|:|||.||..|:|..|:::
plant   239 DVYIWGEVICDNVVKVGIDKNASYLTTRTDVLVPKPLESNIVLDVHQIACGVRHAAFVTRQGEIF 303

  Fly    63 ACGSNDYSQLGHDL--PTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGD--ND 123
            ..|.....:|||.:  ....||:...|......|:|    .||..|:.|::..|::.:|||  ::
plant   304 TWGEESGGRLGHGIGKDVFHPRLVESLTATSSVDFV----ACGEFHTCAVTLAGELYTWGDGTHN 364

  Fly   124 CGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDL 188
            .|.|||.:|.......::...|....|..::||..|:..:||.|.|:::|...:|.||   ..|.
plant   365 VGLLGHGSDISHWIPKRIAGSLEGLHVASVSCGPWHTALITSYGRLFTFGDGTFGVLG---HGDK 426

  Fly   189 THCNYPLRLTTLLGIPLAAIACGGNHSFLISK------------SGAVFGWGRNNCGQLGLNDET 241
            ....||..:.:|.|:...|::||..|:..:.:            ||.:|.||..:..:||..|:.
plant   427 ETVQYPREVESLSGLRTIAVSCGVWHTAAVVEIIVTQSNSSSVSSGKLFTWGDGDKNRLGHGDKD 491

  Fly   242 NRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMG 306
            .|..||.:..|.......:|||...:|.||..|.|||.|:..|||||: ..::..||.:|.:.:.
plant   492 PRLKPTCVPALIDYNFHKIACGHSLTVGLTTSGQVFTMGSTVYGQLGN-LQTDGKLPCLVEDKLA 555

  Fly   307 ST-ITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQ-- 368
            |. :.:::||..|..||. ||..||.:|.|::|:||....:...:|.:|         .||..
plant   556 SEFVEEISCGAYHVAALT-SRNEVYTWGKGANGRLGHGDLEDRKVPTIV---------EALKDRH 610

  Fly   369 ------SNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQC 427
                  .::...::.:.:..||.:||..:|.........:....||..          ...|..|
plant   611 VKYIACGSNYTAAICLHKWVSGAEQSQCSTCRLAFGFTRKRHNCYNCG----------LVHCHSC 665

  Fly   428 KQGLQSDMDLLSSIELIFR-SQACW----NGSFLLDHDRHFGCSVRNHG-----LDLKAAQLA-- 480
            .........|..|...::| ..:|:    ..|.:.|.:|......|..|     ||....:||
plant   666 SSKKAFRAALAPSAGRLYRVCDSCYVKLSKVSEINDTNRRNSAVPRLSGENRDRLDKSEIRLAKF 730

  Fly   481 ----FDNLRAVENESIRQ-----------------------VIWDNI--TKELVGSLVCSPADVE 516
                .|.::.:::::.:|                       .:..||  .:.....|..:|:.:.
plant   731 GTSNMDLIKQLDSKAAKQGKKTDTFSLGRNSQLPSLLQLKDAVQSNIGDMRRATPKLAQAPSGIS 795

  Fly   517 SMRLYLLLPLYHEFVNSKHYKSLQVPFANAIF---KLAENPRK---VLNKWLAQ---------TP 566
            |..   :.|....  :|....:..:|..:.::   .:|:|.:|   :||:.:.:         ..
plant   796 SRS---VSPFSRR--SSPPRSATPMPSTSGLYFPVGIADNMKKTNEILNQEIVKLRTQVDSLTQK 855

  Fly   567 AEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKL-----MKTLCQINN 626
            .|:.|..:||.:......::.....:|.|.:|:...:.|....: ::..||     :|..|..|.
plant   856 CEFQEVELQNSVKKTQEALALAEEESAKSRAAKEAIKSLIAQLK-DVAEKLPPGESVKLACLQNG 919

  Fly   627 ERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTAR-DFNICNYSFIFDQSAK---------TAL 681
                 |:...|::|:.:.:...:.|.:...::..|. ||...|.|:...||.|         :..
plant   920 -----LDQNGFHFPEENGFHPSRSESMTSSISSVAPFDFAFANASWSNLQSPKQTPRASERNSNA 979

  Fly   682 LQADQALQMHSAMANAATMAFSFFN 706
            ..||..|....::.:.....|.|.|
plant   980 YPADPRLSSSGSVISERIEPFQFQN 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	14/56 (25%)
		RCC1	59..110	CDD:278826	13/52 (25%)
		RCC1	114..163	CDD:278826	14/50 (28%)
		RCC1	167..218	CDD:278826	15/50 (30%)
		RCC1	221..270	CDD:278826	16/48 (33%)
		RCC1	273..322	CDD:278826	17/49 (35%)
		RCC1_2	309..339	CDD:290274	11/29 (38%)
		RCC1	327..390	CDD:278826	15/70 (21%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
PRAF1	NP_565144.1	PH_PLC_plant-like	14..124	CDD:270171
		ATS1	238..628	CDD:227511	111/406 (27%)
		FYVE	627..695	CDD:214499	13/77 (17%)
		COG1340	<828..909	CDD:224259	15/81 (19%)
		BRX_N	879..>908	CDD:404581	6/29 (21%)
		BRX	1022..1077	CDD:400608
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920