DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and AT5G12350

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_568268.3	Gene:	AT5G12350 / 831110	AraportID:	AT5G12350	Length:	1075	Species:	Arabidopsis thaliana

Alignment Length:	710	Identity:	189/710 - (26%)
Similarity:	286/710 - (40%)	Gaps:	144/710 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ELYCWG-STSHGQLGLGG--------IEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKV 61
            :::.|| ....|.||.|.        |:.:.:| |..:..|....||.:|||.:|.:.:|..|:.
plant   266 DVFIWGEGIGEGVLGGGNRRVGSSFDIKMDSLL-PKALESTIVLDVQNIACGGQHAVLVTKQGES 329

  Fly    62 YACGSNDYSQLGH--DLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDC 124
            ::.|.....:|||  |...::|:     ||..|....|..:.||..||.|::..|.:.:||..|.
plant   330 FSWGEESEGRLGHGVDSNIQQPK-----LIDALNTTNIELVACGEFHSCAVTLSGDLYTWGKGDF 389

  Fly   125 GQLGHATDKEIVQ-LPKVVRQLVTKT-VVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPND 187
            |.|||.  .|:.. :||.|..|:... |..||||..|:..:||.|:|:::|...:|.||   ..|
plant   390 GVLGHG--NEVSHWVPKRVNFLLEGIHVSSIACGPYHTAVVTSAGQLFTFGDGTFGVLG---HGD 449

  Fly   188 LTHCNYPLRLTTLLGIPLAAIACG------------GNHSFLISKSGAVFGWGRNNCGQLGLNDE 240
            ......|..:.:|.|:.....|||            |:.|.....||.:|.||..:.|:||..::
plant   450 KKSVFIPREVDSLKGLRTVRAACGVWHTAAVVEVMVGSSSSSNCSSGKLFTWGDGDKGRLGHGNK 514

  Fly   241 TNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELM 305
            ..:..||.:..|.......||||...:|.||..|.|:|.|:..|||||:..:..:...|:..:|.
plant   515 EPKLVPTCVAALVEPNFCQVACGHSLTVALTTSGHVYTMGSPVYGQLGNSHADGKTPNRVEGKLH 579

  Fly   306 GSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQS- 369
            .|.:.::|||..| :|::.||..||.:|.||:|:||.........|             .|::|
plant   580 KSFVEEIACGAYH-VAVLTSRTEVYTWGKGSNGRLGHGDVDDRNSP-------------TLVESL 630

  Fly   370 NDSQV-----------SLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRN-----YN---------- 408
            .|.||           ::.|.:..||.|||:.:...     .|..|:.     ||
plant   631 KDKQVKSIACGTNFTAAVCIHRWASGMDQSMCSGCR-----QPFSFKRKRHNCYNCGLVFCHSCT 690

  Fly   409 -PKSQILTLTAEVTKQ---CAQC----KQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGC 465
             .||....:.....|.   |.:|    |:.:::|....||:.   |..:...||..:|.|..|
plant   691 SKKSLKACMAPNPNKPYRVCDKCFNKLKKTMETDPSSHSSLS---RRGSINQGSDPIDKDDKF-- 750

  Fly   466 SVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITK-----ELVGSLVCSPADVESMR--LYLL 523
            ..|:.|      |||..:|.    ||:|||  |:..|     |...|.|.......|.|  |.:.
plant   751 DSRSDG------QLARFSLM----ESMRQV--DSRHKKNKKYEFNSSRVSPIPSGSSQRGALNIA 803

  Fly   524 LPLYHEFVNSKHYKSLQVPFANAIFKL------------AENPRKVLN-----KWLAQTPAEYFE 571
            ......|..||.:.|..||.:..:.:.            :..|...|:     |::........:
plant   804 KSFNPVFGASKKFFSASVPGSRIVSRATSPISRRPSPPRSTTPTPTLSGLATPKFVVDDTKRTND 868

  Fly   572 HLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDR 631
            :|.|..:.           |.:...|..|:.||  ...|||...|.:|....|.||...|
plant   869 NLSQEVVK-----------LRSQVESLTRKAQL--QEVELERTTKQLKEALAITNEETTR 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	16/57 (28%)
		RCC1	59..110	CDD:278826	15/52 (29%)
		RCC1	114..163	CDD:278826	19/50 (38%)
		RCC1	167..218	CDD:278826	15/62 (24%)
		RCC1	221..270	CDD:278826	16/48 (33%)
		RCC1	273..322	CDD:278826	16/48 (33%)
		RCC1_2	309..339	CDD:290274	12/29 (41%)
		RCC1	327..390	CDD:278826	20/74 (27%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
AT5G12350	NP_568268.3	PH_PLC_plant-like	19..129	CDD:270171
		RCC1_2	310..339	CDD:290274	9/28 (32%)
		RCC1	327..375	CDD:278826	15/52 (29%)
		RCC1	378..428	CDD:278826	19/51 (37%)
		RCC1	432..480	CDD:278826	13/50 (26%)
		RCC1	496..544	CDD:278826	15/47 (32%)
		RCC1	547..596	CDD:278826	17/49 (35%)
		RCC1	601..648	CDD:278826	14/59 (24%)
		FYVE	652..719	CDD:279674	14/71 (20%)
		BRX_N	911..946	CDD:290432	2/5 (40%)
		BRX	1006..1060	CDD:285568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920