DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and HECTD3

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_078878.3	Gene:	HECTD3 / 79654	HGNCID:	26117	Length:	861	Species:	Homo sapiens

Alignment Length:	339	Identity:	84/339 - (24%)
Similarity:	140/339 - (41%)	Gaps:	56/339 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   726 QDSLREL-QHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLL--DPKYGMFKEYEQSRL 787
            :|||.:: :....|....|:.:.|....|....|..:      .:|:.  :|....|.:||
Human   545 RDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGE------ARDMYVPNPSCRDFAKYE---- 599

  Fly   788 LWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLS-DLRQLSPPEANSM 851
             |              ||.|.|.|:.....:.|..|..::|:|.|:.|..| |.    |...:.:
Human   600 -W--------------IGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDF----PAVDSVL 645

  Fly   852 QSLLDYQGDDFKEVFDLTF--EIS-RDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNK 913
            ..||:......||.|:..|  |:: ..|..:.:...|.|.|..|.|...:|..|:.|.......:
Human   646 VKLLEVMEGMDKETFEFKFGKELTFTTVLSDQQVVELIPGGAGIVVGYGDRSRFIQLVQKARLEE 710

  Fly   914 SVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWF 978
            |.| ...|...|.:||....|:.:...:||...|.|:.:....||:....: |.:...|..:::|
Human   711 SKE-QVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRF-EDFEPSDSRVQYF 773

  Fly   979 WEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQP------TPDERFLPVAHTCFNLLDLP 1037
            ||.:::.:..::..||.|:||..|:|      .::.|.|      |.|.  ||.:.||.:.|.||
Human   774 WEALNNFTNEDRSRFLRFVTGRSRLP------ARIYIYPDKLGYETTDA--LPESSTCSSTLFLP 830

  Fly  1038 RYKT----KERLKY 1047
            .|.:    :|:|:|
Human   831 HYASAKVCEEKLRY 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	84/339 (25%)
		HECTc	739..1059	CDD:214523	80/325 (25%)
HECTD3	NP_078878.3	APC10-HECTD3	238..371	CDD:176487
HECTD3	NP_078878.3	HECT	579..845	CDD:366212	76/305 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910