DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Herc3

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001348895.1	Gene:	Herc3 / 73998	MGIID:	1921248	Length:	1050	Species:	Mus musculus

Alignment Length:	1078	Identity:	480/1078 - (44%)
Similarity:	665/1078 - (61%)	Gaps:	52/1078 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQ 71
            :.|||..|.||.|:.......:..|....:..|.::::||||..|::||...|:||.||.|...|
Mouse     1 MLCWGYWSLGQPGISSNLQGIVAEPQVCRFVSDRSIKEVACGGNHSVFLLEDGEVYTCGVNTKGQ 65

  Fly    72 LGHDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIV 136
            |||:....:|..     |..|.|..||.:.||..|||||||.||:.|||....||||..|.::.|
Mouse    66 LGHEREGNKPEQ-----IGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSV 125

  Fly   137 QLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNS--PNDLTHCNYPLRLTT 199
            .:|:::::|..:|::|::|||.|.|||.:.|:.::||.|.:||||:..  |:..:    |.|:.:
Mouse   126 AVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTS----PQRVRS 186

  Fly   200 LLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGD 264
            |.|||||.:|.||.|||.:|.||||||||.||.|||||:||.:|..|..:|.|||..|.:::||:
Mouse   187 LEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGE 251

  Fly   265 EFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRV 329
            |.:..||..|||||.|||:.|||||...::|:.||.|:|||||.:||:|||.:||||||||.|.:
Mouse   252 EHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGLI 316

  Fly   330 YAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTL 394
            ||||.|:.|||||..|.::..|..|.|.|.:.| |.|....|.....|::||||||||:.|..:.
Mouse   317 YAFGCGAKGQLGTGHTCNVKCPSPVKGHWAAHS-SQLSARADRFKYRVVKQIFSGGDQTFVLCST 380

  Fly   395 FVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDH 459
            :.:..|..|||..| ::....|..:.|....:.|....::.:.::.:..|..|.||||||||...
Mouse   381 YENSSPAVDFRTVN-QTHYTNLINDETIAVWRQKLTEHNNANTVNGVVQILSSAACWNGSFLEKK 444

  Fly   460 -DRHFGCSVRNHGLDLKAAQLAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLL 523
             |.||..|.:..|:||.:.::.|:.|...::..|.:.|.::....|:..|..||.|||:||:||:
Mouse   445 IDEHFKTSPKIPGIDLNSTRILFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLI 509

  Fly   524 LPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFK 588
            ||.:....:||:|.:|.:|.|.||.:|..||.|||:.|.:|...:||..||..:...|::::
Mouse   510 LPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKGAVLYLL--- 571

  Fly   589 MGLAAASPSAERRQQLLP--YNTELEIILKLMKTLCQIN-NERHDRLNYQIFYWPDLSDYADVQQ 650
                     ..|:..|:|  :|..:...|||::.|.::| ..:|  :.|..||.|::|...|:|:
Mouse   572 ---------RGRKTFLIPVLFNNYMTATLKLLEKLYKVNLKVKH--VEYDKFYIPEISSLVDIQE 625

  Fly   651 EYVKW------------IMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFS 703
            :|:.|            ||.|..   .:|:|.||||..|||.:||.|..|||..|: |.|.:...
Mouse   626 DYLMWFLHQSGMKARPSIMQDAV---TLCSYPFIFDAQAKTKMLQTDAELQMQVAV-NGANLQNV 686

  Fly   704 FFNYGM-PI---SQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFF 764
            |....: |:   |.|:||:|.|.:||.|:||||..:|..|||||||:.|.|||..|||||.||||
Mouse   687 FMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFF 751

  Fly   765 MLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETENMYFLIGVLCGLAIYNFTIINLPFPLALFKK 829
            :||||:||:|.||||..|:.|.||||:|..|...|.:.|||:.|||||||.|:::|.|||||:||
Mouse   752 LLLLKELLNPIYGMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKK 816

  Fly   830 LLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAETKCLKPNGNEIAV 894
            ||.....|.||::|||.|..|:|.||||.|:|.:|.|.|.|.:.|:.:|..|.|.|.|.|:.:||
Mouse   817 LLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEETFCLNFTVCRESYGVIEQKKLIPGGDRVAV 881

  Fly   895 TLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQ 959
            ..:|||||||.||:::|..||...|.||..||:|||.|:|:.:|||.||.|::|||.:|||:.|:
Mouse   882 CKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEELE 946

  Fly   960 DNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGMKALKLTIQPT-PDERF 1023
            :...||..|:|...|:|.|||..|:....:||.|||||||||||||.||.:|::.||.| ..|.:
Mouse   947 ETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIPIYGMASLQIIIQSTATGEEY 1011

  Fly  1024 LPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            |||||||:||||||:|.:||.:|.:|.||:...:||||
Mouse  1012 LPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSL 1049

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	14/47 (30%)
		RCC1	59..110	CDD:278826	21/50 (42%)
		RCC1	114..163	CDD:278826	20/48 (42%)
		RCC1	167..218	CDD:278826	23/52 (44%)
		RCC1	221..270	CDD:278826	27/48 (56%)
		RCC1	273..322	CDD:278826	30/48 (63%)
		RCC1_2	309..339	CDD:290274	19/29 (66%)
		RCC1	327..390	CDD:278826	29/62 (47%)
		HECTc	715..1060	CDD:238033	189/345 (55%)
		HECTc	739..1059	CDD:214523	176/320 (55%)
Herc3	NP_001348895.1	ATS1	2..331	CDD:227511	162/337 (48%)
		RCC1	313..377	CDD:366085	29/64 (45%)
		HECTc	702..1048	CDD:238033	189/345 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I987
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	905	1.000	Inparanoid score	I372
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	1	1.000	-	-		otm43295
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45622
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R774
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.970