DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and hace1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_012818577.2	Gene:	hace1 / 734146	XenbaseID:	XB-GENE-5757512	Length:	1012	Species:	Xenopus tropicalis

Alignment Length:	1189	Identity:	255/1189 - (21%)
Similarity:	422/1189 - (35%)	Gaps:	396/1189 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GLGGIED-----------EQI--LTPS-------QIPWTPDTAV-----QQVACGHRHTLFLTAT 58
            |.||:..           ||:  ||.|       ::|...:|||     ..:|..||..|.|.:.
Frog    56 GPGGLSQYPGLPRMERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVLELLSN 120

  Fly    59 GKV---YA--------------CGS-------------NDYSQLGHDLPTK-RPRMSPFLLIPEL 92
            .|.   ||              |||             .:|..:....|.. ..|......:.:|
Frog   121 SKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKRGADPNYQDISGCTPLHLAARNGQKKCMSKL 185

  Fly    93 QDY-VIIQIC----CGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQ 152
            .:| ..:.||    ..:.|.||::...::|    :|..|  |.|:.:       |...:.:|.:.
Frog   186 LEYNADVNICNNEGLTAIHWLAVNGRTELL----HDLVQ--HVTNVD-------VEDAMGQTALH 237

  Fly   153 IACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFL 217
            :||.|.|...:. |  |...|::|      |.||             :.|......||  :|
Frog   238 VACQNGHKTTVL-C--LLDSGADI------NRPN-------------VSGATPLYFAC--SH--- 275

  Fly   218 ISKSGAVFGWGRNNCGQLGLNDETNRSYPTQLKTLRTLGVRFVACGDEFSVFLTNEGGVF---TC 279
                      |:.:..|:.|              ||  |.:          :|.::.||.   .|
Frog   276 ----------GQRDTAQILL--------------LR--GAK----------YLPDKNGVTPLDLC 304

  Fly   280 GAGAYGQ-----LGH---------GFSSNEMLP----RMVMELMG-----------STITQVACG 315
            ..|.||:     :.|         ..:.||.|.    |.|:|.:.           :.:.:||..
Frog   305 VQGGYGETCDILIQHHPRLFQTLIQMTQNEDLRENTLRQVLEHLSQQSEVQYLKILTGLAEVATT 369

  Fly   316 NRHTLALVPS-------------RGRVYAFGLGSS--------GQLGTRSTKSLMLP-------- 351
            |.|.|..:.|             |...:.|.:|.|        |..|.::.::.:..
Frog   370 NGHKLLSISSSYEAQMKSLLRIVRIFCHVFRIGPSSPNNGNDMGYNGNKTPRNQVFKVRNVYDVF 434

  Fly   352 -QVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQILT 415
             ::.|.....|:.:.:.|:...|..|.:  ::...|:.:|.       :..|..:|....|.|
Frog   435 RKINIKEMNLPNHTLIYQATSEQDPLEL--LWHSLDEWLVL-------IATELTKNKRDSSNI-- 488

  Fly   416 LTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQLA 480
                   .|...||......|    |.|..:|....:||:     .|...|.|..  |.::...|
Frog   489 -------ACILLKQNQLDQQD----ISLAHQSAIGESGSY-----DHLSSSTRAE--DFESCSAA 535

  Fly   481 FDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFAN 545
            .......:.:.:..:..:.::..:....:|...   .|...:..|.:.||| .||
Frog   536 GKQEPVADGQDVISMTANRLSAVIQAFYMCCSC---QMPQGMTSPRFIEFV-CKH---------- 586

  Fly   546 AIFKLAENPRKVLNKWLAQTPAEYFEH---------LVQNFLHVVIHIISFKMGLAAASPSAERR 601
                     ..||..::.:.|...|:|         |:..|:|::           .|.|..||
Frog   587 ---------DDVLKCFVTRNPKIIFDHFHFLLECPELMSRFMHII-----------KAQPFKER- 630

  Fly   602 QQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNI 666
                                |:                               |.
Frog   631 --------------------CE-------------------------------WF---------- 634

  Fly   667 CNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRE 731
              |..:.             |.|..|.|.:            .|:::..:|.|.|:::.:.|...
Frog   635 --YEHLL-------------AGQPDSDMVH------------RPVNENDILLVHRDSIFRSSCEV 672

  Fly   732 LQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFAD-LTF 795
            :...:...||:.:.::|||||....|.|| |:|.:|..::::|.|.:|.:        .|| .||
Frog   673 VFKSNCEKLKQGIAVRFHGEEGMGQGVVR-EWFDILSSEIINPDYALFTQ--------SADGTTF 728

  Fly   796 ETE----------NMYFLIGVLCGLAIYNFTIINLPFPLALFKKLLGKPVDLSDLRQLSPPEANS 850
            :..          |.:...|.:.|||:|:..::|:.|..:.:|.:||.||:..|:..:.|..|.:
Frog   729 QPNSNSSVNPDHLNYFRFAGEILGLALYHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKN 793

  Fly   851 MQSLLDYQGDDFKEV-FDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKS 914
            :|.:||   :|..:: .:|||.:..||||..|...|||.|..|.||.||:.|:|.|..:....::
Frog   794 LQWILD---NDISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTELRMTRA 855

  Fly   915 VELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQALQDNCEYREGYTSVDDTIKWFW 979
            ::...|.|.:||.......:|.:|...||..::.|..:.|......|.||..||...|..|:|||
Frog   856 IQPQINGFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWMKNTEYTSGYERDDQVIQWFW 920

  Fly   980 EVIHDMSEAEKKSFLLFLTGSDRIP------IQGMKALK----LTIQPTPDERFLPVAHTCFNLL 1034
            ||:.::::.|:...|.|:|||.|:|      |.|...|:    ..:..||:  .||.:.||.|:|
Frog   921 EVVQELTQEERVLLLQFVTGSSRVPHGGFAYIMGGSGLQNFTIAAVAYTPN--LLPTSSTCINML 983

  Fly  1035 DLPRYKTKERLKYKLLQAI 1053
            .||.|.:||.||.:||.|:
Frog   984 KLPEYPSKEILKDRLLVAL 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	16/60 (27%)
		RCC1	59..110	CDD:278826	15/86 (17%)
		RCC1	114..163	CDD:278826	11/48 (23%)
		RCC1	167..218	CDD:278826	10/50 (20%)
		RCC1	221..270	CDD:278826	6/48 (13%)
		RCC1	273..322	CDD:278826	18/80 (23%)
		RCC1_2	309..339	CDD:290274	10/50 (20%)
		RCC1	327..390	CDD:278826	11/79 (14%)
		HECTc	715..1060	CDD:238033	115/361 (32%)
		HECTc	739..1059	CDD:214523	111/337 (33%)
hace1	XP_012818577.2	PLN03192	<19..289	CDD:215625	60/298 (20%)
		ANK repeat	134..163	CDD:293786	4/28 (14%)
		ANKYR	<160..288	CDD:223738	37/193 (19%)
		ANK repeat	165..196	CDD:293786	5/30 (17%)
		ANK repeat	198..229	CDD:293786	9/43 (21%)
		ANK repeat	231..262	CDD:293786	10/39 (26%)
		ANK repeat	264..289	CDD:293786	9/55 (16%)
		HECTc	657..1006	CDD:238033	115/360 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910