DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and rpgr

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_031752069.1	Gene:	rpgr / 733454	XenbaseID:	XB-GENE-982274	Length:	1225	Species:	Xenopus tropicalis

Alignment Length:	963	Identity:	211/963 - (21%)
Similarity:	350/963 - (36%)	Gaps:	273/963 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 PSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSNDYSQLGHDLPTKRPRMSPFLLIPELQDY 95
            ||:. |..:....:::||..||:.:|..||:|..|||::.|||.:..:   .:|....:..|:..
Frog    29 PSKF-WLKNDKPARISCGDEHTVLVTGNGKLYVFGSNNWGQLGVEAGS---AISKPTCVKALKSE 89

  Fly    96 VIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHATDKEIVQLPKVVRQLVTKTVVQIACGNNHS 160
            .::...||..|:|..::.|::.|.|.|..||||...........::........:.|::.|:|.|
Frog    90 KVVLAACGRHHTLVYTEQGKLYSSGGNSEGQLGLGDTAGRTSFQEISFFTAQYKIKQLSAGSNMS 154

  Fly   161 LALTSCGELYSWGSNIYGQLGVNSPNDLTHCNYPLRLTTLLGIPLAAIACGGNHSFLISKSGAVF 225
            .|||..|:|:.||.|..||||:.  ....:|. |.::.|  |.|:|.|:||..||..:::.|.::
Frog   155 AALTVDGKLFMWGDNSEGQLGLE--KGTIYCT-PQKVDT--GKPIAWISCGYYHSAFVTQDGELY 214

  Fly   226 GWGRNNCGQLGLNDETNRSYPTQLKTLRTLG----VRFVACGDEFSVFLTNEGGVFTCGAGAYGQ 286
            .:|....|:|||..:..:.:.   |..|.||    |..|:||.|.::.:| |..|:|.|.|.:||
Frog   215 TFGEPENGKLGLPPDKIKKHK---KPQRVLGLSGKVTMVSCGGEHTIAVT-EKEVYTFGLGQFGQ 275

  Fly   287 LGHG-FSSNEMLPRMVMELMGSTITQVACGNRHTLALVPSRGRVYAFGLGSSGQ--LGTRSTKSL 348
            |||| |.....:|:.|..|....|..|.||..|| |::..:|.:|.||.|..|:  ||..:..:.
Frog   276 LGHGTFIFETHIPKAVDALTKKKIRYVTCGENHT-AIITEKGLLYTFGDGRHGKLGLGEENFTNQ 339

  Fly   349 MLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFRNYNPKSQI 413
            .:|              :|.||  .:...::.:..||...:|             |....|:...
Frog   340 FVP--------------ILCSN--FLKFTVQSVACGGCHMLV-------------FATPRPQESE 375

  Fly   414 LTLTAEVTKQCAQCKQGLQSDMDLLSSIELIFRSQACWNGSFLLDHDRHFGCSVRNHGLDLKAAQ 478
            :.:..|: |:.......|..|.::.:|::                         |:|..
Frog   376 VIINDEL-KENLLVVPSLNGDSEMSTSLQ-------------------------RSHSA------ 408

  Fly   479 LAFDNLRAVENESIRQVIWDNITKELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKS----- 538
                .||..|.|:                   ||.....:. ..|.||.:..:||....|
Frog   409 ----RLRRREKET-------------------SPEQFRGLN-RTLPPLRNHSLNSSFLASSKTVP 449

  Fly   539 ---LQVPFANA-------IFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAA 593
               |||..:|:       :..|..|.:        ...|:..|:|||:|
Frog   450 TRLLQVSESNSGSYKETHLQDLTPNSK--------PDAADNGENLVQSF---------------- 490

  Fly   594 ASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMA 658
            ::...:...|...|....::   |..|.....|..:..|:           ::.||:
Frog   491 SAHDTDSDNQPEGYGNTPDV---LNMTHAMSLNPANKTLS-----------FSPVQK-------- 533

  Fly   659 DTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRE- 722
               |..|..|....:|....|..:...::.|: |.|::.:..:....:.....||:...:||.|
Frog   534 ---RKKNTKNVKLKYDGKVDTVQMNKSRSQQL-SLMSSKSQSSDGGDSSAGQNSQYSSADVTEEL 594

  Fly   723 ----NLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYE 783
                .::::...:.:..|        |:||...:.:....|......|:..:|.|      |.||
Frog   595 PIALKIIKEKFHKARETS--------KLKFFSSQEQMQTDVPSSEHQLMASNLSD------KRYE 645

  Fly   784 QSRLLWFADLTFETE---------NMYFLIGVLCGLAIYNFTIIN----LPF----------PLA 825
            :.     :|.|. ||         ||         :.:.|....|    |.|          .::
Frog   646 RQ-----SDSTI-TERQKQHSKHPNM---------ICVKNLEGKNGQKTLKFSAKGSFVSKAEIS 695

  Fly   826 LFKKLLGKPVDLSD-------------LRQLSPPEAN--------------SMQSLLDYQGDDFK 863
            .....|....|:||             |..:...|.|              .||.|.| :.|...
Frog   696 SSSSSLVSSADMSDSRIKRSHKKQHANLHSIQGDEINRLGSSKQKLKENNKEMQKLCD-ESDSQI 759

  Fly   864 EVFDLTFEISRDVFGEAETKCLK---------------PNGNEIAVTLENRQE 901
            .:.:|..|:.::  ||.|.|..|               .|.||..|.:|..:|
Frog   760 NMAELDTEVEQE--GEDEQKSKKGGTWDEDEDAEEEGEGNTNERVVEVEGHKE 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	7/23 (30%)
		RCC1	59..110	CDD:278826	15/50 (30%)
		RCC1	114..163	CDD:278826	12/48 (25%)
		RCC1	167..218	CDD:278826	20/50 (40%)
		RCC1	221..270	CDD:278826	15/52 (29%)
		RCC1	273..322	CDD:278826	21/49 (43%)
		RCC1_2	309..339	CDD:290274	12/29 (41%)
		RCC1	327..390	CDD:278826	14/64 (22%)
		HECTc	715..1060	CDD:238033	49/257 (19%)
		HECTc	739..1059	CDD:214523	45/228 (20%)
rpgr	XP_031752069.1	ATS1	<42..334	CDD:227511	101/304 (33%)
rpgr	XP_031752069.1	RCC1	315..362	CDD:395335	14/62 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010