DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Ube3b

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_001137366.1	Gene:	Ube3b / 687633	RGDID:	1583074	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	943	Identity:	186/943 - (19%)
Similarity:	309/943 - (32%)	Gaps:	327/943 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 SNEMLPRMVMELMGSTITQVACGNR---HTLALVPSRGRVYAFGLGSSGQLGTRSTKSL------ 348
            |::||.:.::.|......|.||.:.   |||.|           :|:...||:.:.|.|
  Rat   280 SHDMLRKFIVFLRDRDRCQDACESLEGCHTLCL-----------MGNLLHLGSLNLKMLEEETDG 333

  Fly   349 ---MLPQV--------------------VIGPWVSPSGSALLQSNDSQVSLVIRQI-FSGGDQSI 389
               :|.|:                    |:| |.|.|....|  ||| :.|:.:|: |..|   :
  Rat   334 FVSLLTQMLCYCQKYVSQKKSNLTHWHPVLG-WFSQSVDYGL--NDS-MYLITKQLQFLWG---V 391

  Fly   390 VTTTLFVDKV-------PPEDF--------------------RNYNPKSQILTL----------T 417
            ....:|...:       |||..                    |.:...:.:..:          :
  Rat   392 PLIRIFFSDILSKKLLEPPEPVPAQPQPSSPQTVLPVKSLLKRAFQKSASVRNILKPVGGRRVDS 456

  Fly   418 AEVTKQCAQCKQGLQSDMDLLSSIELIFRS---------QACWNGSFLLDHDRHFG--------- 464
            .||.|.|:.|.. .|:.:..|:.|.|...:         ...|  :|:.:...|.|
  Rat   457 TEVRKVCSICVL-YQTSLTTLTQIRLQILTGLTYLDDLLPKLW--AFICELGPHGGLKLFLECLN 518

  Fly   465 ----------------CSVRNH------GLDLKAAQLAFD-----NLRAVENESIRQVIWDNITK 502
                            |....|      .:::...|::|.     .:.:..|..:.::|||.|.:
  Rat   519 NDTGESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVE 583

  Fly   503 ELVGSLVCSPADVESMRLY-----LLLPLY-----HEFVNSKHY--KSLQVPFANAIFKLAENPR 555
            ...|         |::.|:     .|:.||     ..|....|:  |.|:   ...:|:..:..|
  Rat   584 NAKG---------ETLELFQSVHGWLMVLYERDCRRRFAPEDHWLRKDLK---PGVLFQELDKDR 636

  Fly   556 KVLNKWLAQTPAEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKT 620
            |.....|...|            |||.|                 :.::|.:.
  Rat   637 KRAQLILLHIP------------HVVPH-----------------KNRVLLFR------------ 660

  Fly   621 LCQINNERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQAD 685
                                                             :.:..:..|..|::..
  Rat   661 -------------------------------------------------NMVIKEKEKLGLVETS 676

  Fly   686 QALQMHSAMANAATMAFSFFNYGMPISQFIV-LNVTRENLVQDSLRELQHYSQSDLKKPLKIKFH 749
            .|                        |..:. :.:.|..:::|...:|:...|..:|..:::||.
  Rat   677 SA------------------------SPHVTHITIRRSRMLEDGYEQLRQLPQHAMKGAIRVKFV 717

  Fly   750 G-----EEAEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWFADLTFETEN---MYFLIGV 806
            .     |...|..||.|||...::|.:.||...:||.......|:.:..::..||   ::..:|.
  Rat   718 SDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK 782

  Fly   807 LCGLAIYNFTIINLPFPLALFKKLLG-------KPVDLSDLRQLSPPEANSMQSLLDYQGDDFKE 864
            :.|.|:|...::::||......::||       ..||  :|..|......::.|:..|.||
  Rat   783 MLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVD--ELPSLDSEFYKNLTSIKRYDGD---- 841

  Fly   865 VFD--LTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFM 927
            |.|  ||.....||.|:.....|.|.|..|.||.||:..::.|...|..:..::....|...||.
  Rat   842 VADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQTAALISGFR 906

  Fly   928 KVCSGRVIHIFQPEELMAVVVG-NEDYDWQALQDNCEYREGYTSVDDTIKWFWEVI-HDMSEAEK 990
            .:.....|.:|...||..::.| |.:.|.:.|:.:..|..|:......|.|.|::: .|.:..|:
  Rat   907 SIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIVWLWDILASDFTPGER 971

  Fly   991 KSFLLFLTGSDRIPIQGMKALK---------------------------LTIQPTPDERFLPVAH 1028
            ..||.|:|...|.|:.|...||                           .||:.......||.:.
  Rat   972 AMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSS 1036

  Fly  1029 TCFNLLDLPRYKTKERLKYKLLQAIQQTQGFSL 1061
            ||||||.||.|..|..|:.||..||....||.|
  Rat  1037 TCFNLLKLPNYSKKSVLREKLRYAISMNTGFEL 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	10/31 (32%)
		RCC1_2	309..339	CDD:290274	8/32 (25%)
		RCC1	327..390	CDD:278826	20/92 (22%)
		HECTc	715..1060	CDD:238033	102/391 (26%)
		HECTc	739..1059	CDD:214523	97/365 (27%)
Ube3b	NP_001137366.1	HECTc	684..1068	CDD:238033	102/389 (26%)
Ube3b	NP_001137366.1	HECTc	709..1067	CDD:214523	97/363 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900