DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and Herc6

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_080268.1	Gene:	Herc6 / 67138	MGIID:	1914388	Length:	1003	Species:	Mus musculus

Alignment Length:	1090	Identity:	352/1090 - (32%)
Similarity:	544/1090 - (49%)	Gaps:	131/1090 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YCWGSTSHG----QLGLGGIEDEQILTPSQIPWTPDTAVQQVACGHRHTLFLTATGKVYACGSND 68
            :.|.:.|..    :.|..|||                 :.|.|.|..|:|.|.:..:||:||.|.
Mouse     3 FSWAAGSRKPRRLKAGTSGIE-----------------LLQAASGEHHSLLLFSNHRVYSCGDNS 50

  Fly    69 YSQLG--HDLPTKRPRMSPFLLIPELQDYVIIQICCGSRHSLALSDWGQVLSWGDNDCGQLGHAT 131
            :.|||  .|..|:||..     |..|.|..:..:.||..||:|:...|:|.:||....||||...
Mouse    51 WGQLGQRRDQSTERPEP-----IQALNDLHVDLVSCGKEHSVAVCHKGKVFAWGAGSEGQLGIGE 110

  Fly   132 DKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGV--NSPNDLTHCNYP 194
            .|||..:|..::.|....::|::||:.|||||:..|.::|||.|..||||:  ||.:..    .|
Mouse   111 FKEISFMPTKIKALAGIKIIQVSCGHYHSLALSEDGHVFSWGRNSEGQLGLGKNSRSQA----IP 171

  Fly   195 LRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGL--NDETNRSY-PTQLKTLRTLG 256
            .::.:|.|||||.:|.||.|||.:|.:|..||||.|..|||.|  |....:.| |..:..|:.|.
Mouse   172 QKVKSLEGIPLAQVAAGGTHSFALSLTGTSFGWGSNRSGQLALSGNKVKEQIYKPHSIGALKNLS 236

  Fly   257 VRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFSSNEMLPRMVMELMGSTITQVACGNRHTLA 321
            |.:::||.|.:..||.||.|||.|..:.|||.....|.:..|::: |.:|..::|:.|.:.||:|
Mouse   237 VIYISCGYEHTAVLTEEGQVFTFGGNSSGQLQPSPRSGQRGPQLI-EGIGGRVSQIECASYHTIA 300

  Fly   322 LVPSRGRVYAFGLGSSGQLGTRSTKSLMLPQVVIGPWVSPSGSALLQSNDSQVSLVIRQIFSGGD 386
            .|.:.|:|.:.|.|.|      .|.:   |.....|..:...:.||.:.| .|.:.::.||:|..
Mouse   301 YVYTTGQVVSLGRGPS------HTSN---PTHQEAPAENSDITCLLAAED-LVDIEVKDIFAGAH 355

  Fly   387 QSIVTT--------TLFVDKVPPEDFRNYNPKSQILTLTAEVTKQCAQC-----KQGLQSDMDLL 438
            .:.|||        |....|:.||          |:.:...:.|:....     ::|.:.:
Mouse   356 ANFVTTRRVSHTRSTGVSMKILPE----------IIRINQSLVKKWRAANKRKDREGAKRE---- 406

  Fly   439 SSIELIFRSQACWNGSFLLDHDRHFGCSVRNH--GLDLKAAQLAFDNLRAVENESIRQVIWDNIT 501
              |.|||.|.||...|||...|     :..|:  .:|||.|:..|..|  ...:.|..:|...:.
Mouse   407 --ISLIFSSSACLTASFLKKRD-----AGENNLIDVDLKLARDVFKKL--TTEKWISSLITTCLE 462

  Fly   502 KELVGSLVCSPADVESMRLYLLLPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTP 566
            :.|:..|..|....|::.::||||......:.|::|:|...||.||.|:.......|....|...
Mouse   463 EYLLRDLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFAKAIHKMGPQSLAFLRTCWASLE 527

  Fly   567 AEYFEHLVQNFLHVVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQ------IN 625
            ......|||.....:|..|.:  |:|.       .|.:......||:|.::.|..||      |.
Mouse   528 VSSLNILVQMLKKAIISQIQY--GVAT-------EQYITNIKVLLEVIKEVHKANCQLPESAFII 583

  Fly   626 NERHDRLNYQIFYWPDLSDYADVQQEYVKWIMADTARDFNICNYS---FIFDQSAKTALLQADQA 687
            ||.....|:.          |:..:.:::....|.....::..:|   |:||..:|..|::.|..
Mouse   584 NELSGIFNFD----------AEAGRMFIRHNDLDCTESSDMVVFSDFLFVFDLPSKIKLMKCDSF 638

  Fly   688 LQMHSAMANAATMAFSFFNYGMPISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEE 752
            :::.|.:     |||.   ..|....:::|.|.|.:||:|:||:|:.....||:|.|.:.|..|.
Mouse   639 VKLMSEV-----MAFP---EKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRKQLSVGFINEI 695

  Fly   753 AEDAGGVRKEFFMLLLKDLLDPKYGMFKEYEQSRLLWF-ADLTFETENMYFLIGVLCGLAIYNFT 816
            ..:||||..|||..:.:::.||||.||...|:...:|| .:..|| ::.|||.|:||||:::|..
Mouse   696 RPEAGGVSSEFFHCIFEEMTDPKYEMFIYPEKGSSMWFPVNPKFE-KSSYFLFGILCGLSLHNLK 759

  Fly   817 IINLPFPLALFKKLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEVFDLTFEISRDVFGEAE 881
            :|||||||||:||||.:...|.||::||.|...::|.:|:.:..|.:|: .:.|.|    :.:.:
Mouse   760 VINLPFPLALYKKLLNQKPSLEDLKELSLPLGRNLQEVLNCEAGDIEEL-HMYFSI----YWDQK 819

  Fly   882 TKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAV 946
            ...|.|:|..:.|...|::::|..|||::||.|::..|..||:||.|||:..:|..|||||||..
Mouse   820 DVDLIPDGISVPVNETNKRDYVSKYVDYIFNISIKTIYEEFHRGFYKVCNWDIIRQFQPEELMTA 884

  Fly   947 VVGNEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIPIQGM--K 1009
            ::||...||:..::|.:|::||.....||..||:..||::..|||.|||||||.||:.::|:  :
Mouse   885 IIGNATCDWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLDEKKKFLLFLTGCDRLHVKGLQNE 949

  Fly  1010 ALKLTIQPTPDERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAIQQTQGF 1059
            .:......|..|...|.:.||..:||||:|.:..|:|..|..||..:.||
Mouse   950 GIVFRCSETFSEEDNPRSLTCHRMLDLPKYSSMRRMKEALQVAINNSTGF 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	11/50 (22%)
		RCC1	59..110	CDD:278826	19/52 (37%)
		RCC1	114..163	CDD:278826	19/48 (40%)
		RCC1	167..218	CDD:278826	24/52 (46%)
		RCC1	221..270	CDD:278826	19/51 (37%)
		RCC1	273..322	CDD:278826	17/48 (35%)
		RCC1_2	309..339	CDD:290274	11/29 (38%)
		RCC1	327..390	CDD:278826	15/62 (24%)
		HECTc	715..1060	CDD:238033	139/348 (40%)
		HECTc	739..1059	CDD:214523	128/322 (40%)
Herc6	NP_080268.1	RCC1 1	40..91		20/55 (36%)
		RCC1	40..89	CDD:278826	19/53 (36%)
		RCC1 2	92..144		21/51 (41%)
		RCC1	92..142	CDD:278826	19/49 (39%)
		RCC1	145..195	CDD:278826	24/53 (45%)
		RCC1 3	146..197		24/54 (44%)
		RCC1_2	183..211	CDD:290274	14/27 (52%)
		RCC1 4	199..252		20/52 (38%)
		RCC1_2	237..266	CDD:290274	12/28 (43%)
		RCC1 5	253..303		18/50 (36%)
		RCC1	253..300	CDD:278826	17/47 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281		5/19 (26%)
		chaperonin_like	<570..>652	CDD:295468	20/99 (20%)
		HECTc	658..999	CDD:238033	137/346 (40%)
		HECTc	682..999	CDD:214523	128/322 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57432
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0001110
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45622
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.890