DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Herc4 and HACE1

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens

Alignment Length:	819	Identity:	196/819 - (23%)
Similarity:	344/819 - (42%)	Gaps:	144/819 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 VMELMGSTITQVACGNRH---TLALVPSRGRVYAFGLGSSGQL------GTRSTKSLMLPQVVIG 356
            |.:.||.|...|||.|.|   ...|:.|...:....:..:..|      |.|.|..::|   :.|
Human   159 VEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILL---LRG 220

  Fly   357 PWVSPSGSAL------LQSNDSQVSLVIRQIFSGGDQSIVTTTLFVDKVPPEDFR---------- 405
            ....|..:.:      :|....:...|:.|......|:|:..|      ..||.|
Human   221 AKYLPDKNGVTPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMT------QNEDLRENMLRQVLEH 279

  Fly   406 -NYNPKSQ---ILTLTAEVTKQCAQCKQGLQSDMDL-LSSIELIFRSQACWNGSFLLDHDRHFGC 465
             :...:||   |||..|||..........|.|:.|. :.|:..|.|         :..|....|.
Human   280 LSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSLLRIVR---------MFCHVFRIGP 335

  Fly   466 SVRNHGLDLKAAQLAFDNLRAVENESIR--QVIWDNITKELV---GSLVCSPADVESMRLYLL-- 523
            |..::|:|     :.::..:...::..:  :::|.::.:.||   ..|:.:..|...:...||
Human   336 SSPSNGID-----MGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKRDSTEITSILLKQ 395

  Fly   524 ---------LPLYHEFVNSKHYKSLQVPFANAIFKLAENPRKVLNKWLAQTPAEYFEHLVQNFLH 579
                     :|.: |......|::|......:      .|..:..:..|....:....:..|.|.
Human   396 KGQDQDAASIPPF-EPPGPGSYENLSTGTRES------KPDALAGRQEASADCQDVISMTANRLS 453

  Fly   580 VVIHIISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSD 644
            .||.  :|.|..:...|......:.:.:..:.:.:||     |.:|  |:.::.:..|::  |.:
Human   454 AVIQ--AFYMCCSCQMPPGMTSPRFIEFVCKHDEVLK-----CFVN--RNPKIIFDHFHF--LLE 507

  Fly   645 YADVQQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQALQMHSAMANAATMAFSFFNYGM 709
            ..::...::..|.|...:|  .|.:.:                ..:||...::..:       ..
Human   508 CPELMSRFMHIIKAQPFKD--RCEWFY----------------EHLHSGQPDSDMV-------HR 547

  Fly   710 PISQFIVLNVTRENLVQDSLRELQHYSQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLDP 774
            |:::..:|.|.|:::.:.|...:...:.:.||:.:.::|||||....|.|| |:|.:|..::::|
Human   548 PVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVR-EWFDILSNEIVNP 611

  Fly   775 KYGMFKEYEQSRLLWFAD-LTFETE----------NMYFLIGVLCGLAIYNFTIINLPFPLALFK 828
            .|.:|.:        .|| .||:..          |.:...|.:.|||:.:..::|:.|..:.:|
Human   612 DYALFTQ--------SADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYK 668

  Fly   829 KLLGKPVDLSDLRQLSPPEANSMQSLLDYQGDDFKEV-FDLTFEISRDVFGEAETKCLKPNGNEI 892
            .:||.||:..|:..:.|..|.::|.:||   :|..:: .:|||.:..||||..|...|||.|..|
Human   669 HILGIPVNYQDVASIDPEYAKNLQWILD---NDISDLGLELTFSVETDVFGAMEEVPLKPGGGSI 730

  Fly   893 AVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFMKVCSGRVIHIFQPEELMAVVVGNEDYDWQA 957
            .||..|:.|:|.|..:....::::...|||.:||.......:|.:|...||..::.|..:.|...
Human   731 LVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSD 795

  Fly   958 LQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEKKSFLLFLTGSDRIP------IQGMKALK-LTI 1015
            ...|.||..||...|..|:|||||:.|:::.|:...|.|:|||.|:|      |.|...|: .||
Human   796 WIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTI 860

  Fly  1016 QPTP-DERFLPVAHTCFNLLDLPRYKTKERLKYKLLQAI 1053
            ...| ....||.:.||.|:|.||.|.:||.||.:||.|:
Human   861 AAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVAL 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826	9/23 (39%)
		RCC1_2	309..339	CDD:290274	7/32 (22%)
		RCC1	327..390	CDD:278826	11/74 (15%)
		HECTc	715..1060	CDD:238033	116/359 (32%)
		HECTc	739..1059	CDD:214523	112/335 (33%)
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894	27/132 (20%)
		ANK 1	64..93
		ANK repeat	66..95	CDD:293786
		ANK	92..217	CDD:238125	15/57 (26%)
		ANK repeat	97..128	CDD:293786
		ANK 2	97..126
		ANK repeat	130..161	CDD:293786	1/1 (100%)
		ANK 3	130..159		196/819 (24%)
		ANK repeat	163..194	CDD:293786	10/30 (33%)
		ANK 4	163..192		10/28 (36%)
		ANK 5	196..226		6/32 (19%)
		ANK repeat	196..221	CDD:293786	5/27 (19%)
		ANK 6	228..257		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433		5/41 (12%)
		HECTc	554..903	CDD:238033	116/358 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810