DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and rpgra

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_021334464.1	Gene:	rpgra / 571327	ZFINID:	ZDB-GENE-070912-423	Length:	1692	Species:	Danio rerio

Alignment Length:	337	Identity:	107/337 - (31%)
Similarity:	165/337 - (48%)	Gaps:	42/337 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LYCWGSTSHGQLGLGGIEDEQILTPSQIP----WTPDTAVQQVACGHRHTLFLTATGKVYACGSN 67
            |:.:|..:.|||||      ||..|...|    .......|.||||..|||..|:.|::.|.|.|
Zfish    49 LFVFGDNNRGQLGL------QIKGPVTKPVCVKVLKGERAQSVACGTDHTLVSTSQGEILAAGGN 107

  Fly    68 DYSQLG----HDLPTKRPRMSPFLLIPELQDYVIIQICCGSRH-SLALSDWGQVLSWGDNDCGQL 127
            ...|||    :| .....|:.||.      ||..|::.....| |.||::.|::..||||..|||
Zfish   108 SDGQLGLGHCND-SISFQRLRPFC------DYAPIKLLSAGDHTSAALTEDGRLFLWGDNSAGQL 165

  Fly   128 GHATDKEIVQLPKVVRQLVTKTVVQIACGNNHSLALTSCGELYSWGSNIYGQLGVNSPNDLTHCN 192
            |...|...: |||.:.  :.:::..::||..||..:|..|::||:|.:..|:||: |.:.|.:.:
Zfish   166 GFGNDSHAL-LPKELN--MGQSIHWVSCGYRHSALVTDSGDVYSFGESADGRLGL-SAHQLANHS 226

  Fly   193 YPLRLTTLLGIPLAAIACGGNHSFLISKSGAVFGWGRNNCGQLGLN------DETNRSYPTQLKT 251
            ||.|:.:|..:  ..:||||.|:..:::. .::.:|....|||||.      |.     |..:..
Zfish   227 YPQRVESLHSV--LQVACGGKHTLALTED-ELYCFGGGEFGQLGLGTLVFVADS-----PVAVGH 283

  Fly   252 LRTLGVRFVACGDEFSVFLTNEGGVFTCGAGAYGQLGHGFS--SNEMLPRMVMELMGSTITQVAC 314
            .|...|..|.||::.|..:|:.|.::|.|.|.:|:||||..  :|:..|.:.......::..|||
Zfish   284 FRKGRVTHVTCGEQHSALITDSGLLYTFGDGRHGKLGHGDENFTNQFTPTVCQRFFEYSVMTVAC 348

  Fly   315 GNRHTLALVPSR 326
            |:.|.|.....|
Zfish   349 GSSHMLVFARPR 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826	19/51 (37%)
		RCC1	59..110	CDD:278826	16/55 (29%)
		RCC1	114..163	CDD:278826	17/48 (35%)
		RCC1	167..218	CDD:278826	18/50 (36%)
		RCC1	221..270	CDD:278826	14/54 (26%)
		RCC1	273..322	CDD:278826	17/50 (34%)
		RCC1_2	309..339	CDD:290274	7/18 (39%)
		RCC1	327..390	CDD:278826	107/337 (32%)
		HECTc	715..1060	CDD:238033
		HECTc	739..1059	CDD:214523
rpgra	XP_021334464.1	RCC1	5..43	CDD:306840
		RCC1	<31..324	CDD:332518	98/299 (33%)
		RCC1	305..352	CDD:306840	15/46 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920