DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Herc4 and trip12

DIOPT Version :9

Sequence 1:	NP_001261249.1	Gene:	Herc4 / 38151	FlyBaseID:	FBgn0035207	Length:	1062	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	661	Identity:	153/661 - (23%)
Similarity:	243/661 - (36%)	Gaps:	198/661 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 ENESIRQVIWDNITKELVGSLVCSPA-----DVESMRLYLLLPLYH------------------- 528
            ::|...:.:..::...|...|:|.|.     |..||.:.|||.:.|
Zfish  1537 QDELWHEGVCPSVANPLETYLICDPPEGITFDDPSMEVILLLRVLHSISRYWFYLYDNAACKEII 1601

  Fly   529 ---EFVNS----KHYKSLQVPFANAIFKLAENPRKVLNKWLAQ---TPAEYFEHLVQNFLHVVIH 583
               ||:||    |..:.||.|.   :......|     .||.:   |...:|....:..|   .:
Zfish  1602 PTGEFINSKLTAKANRQLQDPL---VIMTGNIP-----TWLTELGKTCPFFFPFDTRQML---FY 1655

  Fly   584 IISFKMGLAAASPSAERRQQLLPYNTELEIILKLMKTLCQINNERHDRLNYQIFYWPDLSDYADV 648
            :.:|....|        .|:||..|.|:                                :.:|.
Zfish  1656 VTAFDRDRA--------MQRLLDTNPEI--------------------------------NQSDS 1680

  Fly   649 QQEYVKWIMADTARDFNICNYSFIFDQSAKTALLQADQAL-QMHSAMANAATMAFSFFNYGMPIS 712
            |...|      ..|          .|:..:|  :..|:.| |..|.|.:..             |
Zfish  1681 QDSRV------APR----------LDRKKRT--INRDELLKQAESVMQDLG-------------S 1714

  Fly   713 QFIVLNVTRENLVQDSLRELQHY----SQSDLKKPLKIKFHGEEAEDAGGVRKEFFMLLLKDLLD 773
            ...:|.:..||.|...|...|.:    ||...:..|.: :.|||.                .|.:
Zfish  1715 SRAMLEIQYENEVGTGLGPTQEFYALVSQELQRADLGL-WRGEEV----------------TLSN 1762

  Fly   774 PKYG-------MFKEYEQSRLLWFADLTFETE-------NMYF-LIGVLCGLAIYNFTIINLPFP 823
            ||.|       ||    .||.|:.......|:       .|.| .:|.|...||.:|.:::||..
Zfish  1763 PKVGSQEGTKYMF----SSRGLFAVPFGRTTKPAHIAKIKMKFRFLGKLMAKAIMDFRLLDLPLG 1823

  Fly   824 LALFKKLLGKPVDLS--DLRQLSPPEANSMQSLLD-------------YQGDDFKE--------- 864
            |..:|.:|.....:|  ||..:.|..|.|:|.|.|             :..:..::
Zfish  1824 LPFYKWMLRHESSISSHDLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQQALESLNMNG 1888

  Fly   865 --VFDLTFEISRDVFGEAETKCLKPNGNEIAVTLENRQEFVDLYVDFVFNKSVELHYNAFHKGFM 927
              |.||..:.:...|...|   ||..|.::.||:.|.::::.|.|.:..|:.|...:.:|.:||.
Zfish  1889 CSVEDLGLDFTLPGFPNIE---LKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESFREGFE 1950

  Fly   928 KVCSGRVIHIFQPEELMAVVVG--NEDYDWQALQDNCEYREGYTSVDDTIKWFWEVIHDMSEAEK 990
            .|.....:..|.||||..::.|  :|.:|.:.|.:.|....|||.....:::.:||:......::
Zfish  1951 SVFPLHHLQYFYPEELDQLLCGSKSESWDVKTLMECCRPDHGYTHDSRAVRFLFEVLSSFDAEQQ 2015

  Fly   991 KSFLLFLTGSDRIPIQGMKALK--LTI-------QPTPDERFLPVAHTCFNLLDLPRYKTKERLK 1046
            :.||.|:|||.|:|:.|.::|.  |||       ...||: |||...||.|.|.||.|.:.|.::
Zfish  2016 RLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDD-FLPSVMTCVNYLKLPDYSSIEIMR 2079

  Fly  1047 YKLLQAIQQTQ 1057
            .|||.|.::.|
Zfish  2080 EKLLIAAREGQ 2090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Herc4	NP_001261249.1	RCC1	6..55	CDD:278826
		RCC1	59..110	CDD:278826
		RCC1	114..163	CDD:278826
		RCC1	167..218	CDD:278826
		RCC1	221..270	CDD:278826
		RCC1	273..322	CDD:278826
		RCC1_2	309..339	CDD:290274
		RCC1	327..390	CDD:278826
		HECTc	715..1060	CDD:238033	108/399 (27%)
		HECTc	739..1059	CDD:214523	100/371 (27%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915
		HECTc	1693..2094	CDD:238033	115/438 (26%)
		HECTc	1711..2090	CDD:214523	108/416 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900